Bacteremia Due to Multiresistant Gram-Negative Bacilli in Neutropenic Cancer Patients: A Case Controlled Study

Krčméry, V.; Špánik, S.; Krupova, I.; Trupl, J.; Kunová, A.; Smid, M.; Pichnova, E.

doi:10.1179/joc.1998.10.4.320

Cited by 34 publications

(13 citation statements)

References 5 publications

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“…Recent studies have reported crude mortality rates for bacteremia ranging between 10% and 69%; the mortality rate ranged from 12% to 42% 5,10,33,34 in neutropenic patients with bacteremia, with the highest rates usually related to gram-negative bacteria, 5,10 and reached 83% among those hospitalized in an intensive care unit. 35e37 During eight years of surveillance, the overall mortality associated with BSI caused by E. coli in patients with hematological malignancies was 20.9%.…”

Section: Discussionmentioning

confidence: 98%

Incidence and clinical impact of extended-spectrum-β-lactamase (ESBL) production and fluoroquinolone resistance in bloodstream infections caused by Escherichia coli in patients with hematological malignancies

Trecarichi¹,

Tumbarello²,

Spanu³

et al. 2009

Journal of Infection

150

109

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Section: Discussionmentioning

confidence: 98%

Incidence and clinical impact of extended-spectrum-β-lactamase (ESBL) production and fluoroquinolone resistance in bloodstream infections caused by Escherichia coli in patients with hematological malignancies

Trecarichi¹,

Tumbarello²,

Spanu³

et al. 2009

Journal of Infection

150

109

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“…13,18,31 This microorganism appears in intensive care unit patients and has been associated with bacteremia, endocarditis, respiratory and urinary tract infections, 11,14,17,20,30 as well as cystic fibrosis. [6][7][8] Some studies show that most infections due to S. maltophilia present a high clonal diversity.…”

Section: Introductionmentioning

confidence: 99%

Mutations ingyrAandparCQRDRs Are Not Relevant for Quinolone Resistance in Epidemiological UnrelatedStenotrophomonas maltophiliaClinical Isolates

Ribera

Doménech-Sánchez

Ruiz

et al. 2002

Microbial Drug Resistance

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Clinical strains of Stenotrophomonas maltophilia are often highly resistant to multiple antibiotics and this resistance is steadily rising. Quinolones are included in the group of antimicrobial agents to which this microorganism is developing resistance. Therefore, the aim of this study was to analyze the epidemiological relationship among 22 clinical isolates of S. maltophilia as well as the molecular mechanisms responsible for the acquisition of quinolone-resistance in these strains. The results of the pulsed-field gel electrophoresis (PFGE) showed an heterogenicity of 82% among the strains used in the study. On the other hand, no amino acid changes were found in the quinolone resistance-determining region (QRDR) of either gyrA and parC genes among quinolone-susceptible and -resistant S. maltophilia strains. Besides, the amino acid of the GyrA found in the position equivalent to Ser-83 of E. coli was Gln instead of a Ser or Thr, the amino acids usually encountered in this position among Gram-negative bacteria. The results suggest that there is not a relationship between the presence of this Gln and the resistance to quinolones in S. maltophilia. We can conclude that, contrary to what has been described in other microorganisms, in these S. maltophilia isolates, the development of resistance to quinolones was not related to mutations in the QRDR of gyrA and parC genes. Thus, to our knowledge, this is the first report describing this phenomenon.

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“…6 Multidrug-resistant gn bacteremia in adult patients with febrile neutropenia is associated with prolonged hospitalization, increased treatment-related adverse effects, higher healthcare costs and an increase in both infection-related and allcause mortality. [7][8][9][10] However, few studies have investigated risk factors and outcome associated with antibiotic-resistant (ar) gn bacteremia in children with febrile neutropenia. 11,12 Predicting which patients are at risk of ar gn bacteremia is a potential way to improve outcome while controlling antibiotic use.…”

mentioning

confidence: 99%

Antibiotic-resistant Gram-negative Bacteremia in Pediatric Oncology Patients—Risk Factors and Outcomes

Haeusler¹,

Méchinaud²,

Daley³

et al. 2013

Pediatric Infectious Disease Journal

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Bacteremia Due to Multiresistant Gram-Negative Bacilli in Neutropenic Cancer Patients: A Case Controlled Study

Cited by 34 publications

References 5 publications

Incidence and clinical impact of extended-spectrum-β-lactamase (ESBL) production and fluoroquinolone resistance in bloodstream infections caused by Escherichia coli in patients with hematological malignancies

Incidence and clinical impact of extended-spectrum-β-lactamase (ESBL) production and fluoroquinolone resistance in bloodstream infections caused by Escherichia coli in patients with hematological malignancies

Mutations ingyrAandparCQRDRs Are Not Relevant for Quinolone Resistance in Epidemiological UnrelatedStenotrophomonas maltophiliaClinical Isolates

Antibiotic-resistant Gram-negative Bacteremia in Pediatric Oncology Patients—Risk Factors and Outcomes

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