Bacteremia associated with pressure ulcers: a prospective cohort study

Espejo, Elena; Andrés, Marta; Borrallo, Rosa M.; Padilla, Emma; García-Restoy, Enric; Bella, Feliu

doi:10.1007/s10096-018-3216-8

Cited by 49 publications

(55 citation statements)

References 39 publications

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“…Among these, one-half only evaluated inhospital outcomes including two studies that restricted to intensive care unit (ICU) outcome alone16,17 with the other three limited to inhospital death 18–20. The other one-half of studies evaluated 30-day,21,22 90-day,23,24 and 6-month25 all-cause deaths. We chose BSI to study this issue as a matter of convenience as we had ready access to a detailed population-based database.…”

Section: Discussionmentioning

confidence: 99%

Inhospital death is a biased measure of fatal outcome from bloodstream infection

Laupland¹,

Pasquill²,

Parfitt³

et al. 2019

CLEP

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PurposeInhospital death is commonly used as an outcome measure. However, it may be a biased measure of overall fatal outcome. The objective of this study was to evaluate inhospital death as a measure of all-cause 30-day case fatality in patients with bloodstream infection (BSI).Patients and methodsA population-based surveillance cohort study was conducted, and patients who died in hospital within 30 days (30-day inhospital death) were compared with those who died in any location by day 30 post BSI diagnosis (30-day all-cause case fatality).ResultsA total of 1,773 residents had first incident episodes of BSI. Overall, 299 patients died for a 30-day all-cause case fatality rate of 16.9%. Most (1,587; 89.5%) of the patients were admitted to hospital, and ten (5.4%) of the 186 patients not admitted to hospital died. Of the 1,587 admitted patients, 242 died for a 30-day inhospital death rate of 15.2%. A further 47 patients admitted to hospital died after discharge but within 30 days of BSI diagnosis for a 30-day case fatality rate among admitted patients of 18.2%. Patients who died following discharge within 30 days were older and more likely to have dementia.ConclusionThe use of inhospital death is a biased measure of true case fatality.

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Section: Discussionmentioning

confidence: 99%

Inhospital death is a biased measure of fatal outcome from bloodstream infection

Laupland¹,

Pasquill²,

Parfitt³

et al. 2019

CLEP

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show abstract

“…Bloodstream infections represent a major public health problem being a significant cause of morbidity and mortality worldwide [1–5]. Polymicrobial bloodstream infection is particularly severe, and is commonly associated with dramatically high mortality rates [6–8]. Blood culture (BC), the “gold standard” for the diagnosis of bloodstream infection, requires at least 48–72 h before the results of microbial identification and antimicrobial susceptibility testing can be reported to clinicians.…”

Section: Introductionmentioning

confidence: 99%

A new culture-based method for rapid identification of microorganisms in polymicrobial blood cultures by MALDI-TOF MS

et al. 2019

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BackgroundThe application of matrix-assisted laser desorption/ionization time of flight (MALDI-TOF) mass spectrometry (MS) to microbial identification has allowed the development of rapid methods for identification of microorganisms directly in positive, blood cultures (BCs). These methods can yield accurate results for monomicrobial BCs, but often fail to identify multiple microorganisms in polymicrobial BCs. The present study was aimed at establishing a rapid and simple method for identification of bacteria and yeast in polymicrobial BCs from patients with bloodstream infection.ResultsThe rapid method herein proposed is based on short-term culture in liquid media allowing selective growth of microorganisms recovered from polymicrobial BCs, followed by rapid identification by MALDI-TOF MS. To evaluate the accuracy of this method, 56 polymicrobial BCs were comparatively analyzed with the rapid and routine methods. The results showed concordant identification for both microbial species in 43/50 (86%) BCs containing two different microorganisms, and for two microbial species in six BCs containing more than two different species. Overall, 102/119 (85.7%) microorganisms were concordantly identified by the rapid and routine methods using a cut-off value of 1.700 for valid identification. The mean time to identification after BC positivity was about 4.2 h for streptococci/enterococci, 8.7 h for staphylococci, 11.1 h for Gram-negative bacteria, and 14.4 h for yeast, allowing a significant time saving compared to the routine method.ConclusionsThe proposed method allowed rapid and reliable microbial identification in polymicrobial BCs, and could provide clinicians with timely, useful information to streamline empirical antimicrobial therapy in critically ill patients.

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“…Above results showed YB treatment reduce acne wound area of HAPU patients with S. aureus positive in wound pathogens detecting (Table 1). At present, a number of research reports that S. aureus associated with pressure ulcers 19, 20. Therefore, the antibacterial effects of YB on S. aureus were evaluated.…”

Section: Resultsmentioning

confidence: 99%

Yunnan Baiyao reduces hospital-acquired pressure ulcers via suppressing virulence gene expression and biofilm formation of Staphylococcus aureus

Cai

Yan

et al. 2019

Int. J. Med. Sci.

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Yunnan Baiyao (YB) as a kind of famous Chinese herbal medicine, possessed hemostatic, invigorating the circulation of blood, and anti-inflammatory effects. Identifying strategies to protect patients at risk for hospital-acquired pressure ulcers (HAPU) is essential. Herein, our results showed that YB treatment can effectively reduce the acne wound area and improve efficacy in a comparative study of 60 cases HAPU patients with S. aureus positive of acne wound pathogens. Furthermore, YB inhibited HIa expression and suppressed accessory gene regulator (agr) system controlled by regulatory RNA II and RNA III molecule using pALC1740, pALC1742 and pALC1743 S. aureus strain linked to gfpuvr reporter gene. Moreover, YB downregulated cao mRNA expression and inhibited coagulase activity by RT-PCR, slide and tube coagulase test. Additionally, YB downregulated seb, sec, sed, and tsst-1 mRNA expression to suppress enterotoxin and tsst-1 secretion and adhesion function related genes sarA, icaA, and cidA mRNA expression. Taken together, the data suggest that YB may reduce HAPU via suppressing virulence gene expression and biofilm formation of S. aureus.

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Bacteremia associated with pressure ulcers: a prospective cohort study

Cited by 49 publications

References 39 publications

Inhospital death is a biased measure of fatal outcome from bloodstream infection

Inhospital death is a biased measure of fatal outcome from bloodstream infection

A new culture-based method for rapid identification of microorganisms in polymicrobial blood cultures by MALDI-TOF MS

Yunnan Baiyao reduces hospital-acquired pressure ulcers via suppressing virulence gene expression and biofilm formation of Staphylococcus aureus

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