Bacteremia as an adverse event of fecal microbiota transplantation in a patient with Crohn's disease and recurrent Clostridium difficile infection

Quera, Rodrigo; Espinoza, Ricardo; Estay, Camila; Rivera, Daniela

doi:10.1016/j.crohns.2013.10.002

Cited by 136 publications

(83 citation statements)

References 5 publications

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“…The authors did not indicate an issue with colitis flares, although transient fever and rise in inflammatory markers were common (15% in Colman et al) [109,110]. They identified only one published report with an infective complication involving a 61 year-old patient treated with mesalazine, azathioprine and infliximab for Crohn's disease [111]. The patient had experienced 6 episodes of E. coli bacteremia and 4 of CDI over a 4-year period.…”

Section: Data From the Literature On Fmt And Immunocompromised Patientsmentioning

confidence: 93%

Fecal microbiota transplantation (FMT) for Clostridium difficile infection: Focus on immunocompromised patients

Bella¹,

Gouliouris²,

Petrosillo³

2015

Journal of Infection and Chemotherapy

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Section: Data From the Literature On Fmt And Immunocompromised Patientsmentioning

confidence: 93%

Fecal microbiota transplantation (FMT) for Clostridium difficile infection: Focus on immunocompromised patients

Bella¹,

Gouliouris²,

Petrosillo³

2015

Journal of Infection and Chemotherapy

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“…There have been a small number of reports in adults of complications from FMT for recurrent CDI including worsening colitis in a patient with IBD (37) and bacteremia (38). While mild transient symptoms including abdominal pain, vomiting, and loose stool have been described in pediatric cases, no long-term complications have been reported in children as a result of FMT for CDI; follow up in pediatric case series has been variable, although some patients have been followed for up to 2 y (25,28).…”

Section: Fecal Transplant In Childrenmentioning

confidence: 99%

Fecal microbiota transplantation in children: a brief review

Hourigan

Oliva-Hemker

2016

Pediatr Res

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There has been a growing interest in fecal microbiota transplantation (FMT) over recent years, in part due to the increasing prevalence of Clostridium difficile infection (CDI) and expanding association of intestinal dysbiosis with a wide range of human diseases. Many adult studies have shown that FMT is an effective treatment for recurrent CDI and may possibly have applications in other illnesses such as inflammatory bowel disease (IBD); however, there is a paucity of data available in children who may differ from adults for many reasons including having a dynamic developing microbiome compared to adults who have a relatively stable microbiome. Here, we review published studies looking at FMT in children, for CDI and IBD, and discuss special considerations needed when conducting FMT in children.

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“…As a consequence, manipulation of the intestinal microbiota is a very attractive therapeutic approach. In spite of the fact that so far results have been often negative [144], and even bacteremia as an adverse event has been reported [145], positive results have also been achieved [146]. To improve safety, clearly the transplanted microbiota should be carefully screened for pathogens [147].…”

Section: Fecal Microbiota Transplantationmentioning

confidence: 95%