Bacteremia after hematopoietic stem cell transplantation: incidence and predictive value of surveillance cultures

Frère, Pascale; Hermanne, J-P; Debouge, M. H.; Mol, Pieter de; Fillet, Georges; Béguin, Yves

doi:10.1038/sj.bmt.1704414

Cited by 45 publications

(52 citation statements)

References 24 publications

(48 reference statements)

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“…This was particularly true in the early post-transplant phase, but remained so thereafter as well, albeit to a lesser extend. Among them, Gram-positive bacteria were the agents most frequently responsible for infection, in agreement with data in standard allogeneic transplantation [27][28][29][30] and probably related to the fact that all patients carried a central venous catheter device. Similarly, the pattern of fungal infections was consistent with previous studies 9, 10 that reported incidences of proven or probable fungal infection in NMSCT recipients 12,16,17 comparable to those observed in standard transplants after a myeloablative conditioning 31,32 .…”

Section: Discussionsupporting

confidence: 67%

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Infections after allogeneic hematopoietic stem cell transplantation with a nonmyeloablative conditioning regimen

Frère

Baron

Bonnet

et al. 2006

Bone Marrow Transplant

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Hematopoietic cell transplantation (HCT) following nonmyeloablative conditioning (NMSCT) could be associated with a reduced risk of infection compared to standard allogeneic HCT. We retrospectively analyzed incidence and risk factors of infection in 62 patients undergoing NMSCT with low-dose TBI +/-fludarabine and postgrafting CsA and MMF. The proportion of patients with any infection was 77%, but the majority of infectious events occurred beyond day 30. Donor other than sibling, older age, early disease and male gender were significant risk factors. The incidence of bacteraemia was 55% at 1 yr and the number of bacteraemic episodes was 0.9 per patient (0.08 before day 30). The risk of bacteraemia increased with older age and the use of a donor other than an HLAidentical sibling, but not with neutropenia. The incidence of infections other than bacteraemia correlated with the use of corticosteroids. The risk of CMV infection increased with high-risk CMV serology, and risk of CMV disease with high-risk CMV serology, older age, first transplantation and a diagnosis of lymphoma. In conclusion, after NMSCT, infections are not frequent in the first 30 days post-transplant but careful long-term monitoring is necessary thereafter.

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Section: Discussionsupporting

confidence: 67%

“…Bacteraemias occur in about 20% to 60% of the cases after allogeneic HCT 28 . In our study, the incidence of bacteraemia at one year was 55%.…”

Section: Discussionmentioning

confidence: 99%

Infections after allogeneic hematopoietic stem cell transplantation with a nonmyeloablative conditioning regimen

Frère

Baron

Bonnet

et al. 2006

Bone Marrow Transplant

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“…General trends in contemporary studies include an overall decreased incidence of BSI compared to earlier studies. 22,36,37 While the overall incidence of BSI by gram negative bacteria has decreased, the proportion of BSI caused by fluoroquinolone-resistant bacteria has increased compared with prior studies (Table 1). Similarly, contemporary microbial epidemiology data in pediatric HCT over the last 5 years demonstrates a decrease in CLABSI rates with a suggestive trend toward less predominance of gram positive bacteria and selection of multidrug resistant (MDR) pathogens (Table 2).…”

Section: Emerging Resistance In Bloodstream Infection Pathogens In Thmentioning

confidence: 63%

Bacterial bloodstream infections in the allogeneic hematopoietic cell transplant patient: new considerations for a persistent nemesis

Dandoy

Ardura

Papanicolaou

et al. 2017

Bone Marrow Transplant

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Bacterial bloodstream infections (BSI) cause significant transplant-related morbidity and mortality following allogeneic hematopoietic cell transplantation (allo-HCT). This manuscript reviews the risk factors for and the bacterial pathogens causing BSIs in allo-HCT recipients in the contemporary transplant period. In addition, it offers insight into emerging resistant pathogens and reviews clinical management considerations to treat and strategies to prevent BSIs in allo-HCT patients.

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“…All patients were managed with a totally implanted Port-A-Cath catheter (Braun, Melsungen, Germany) that remained in place at least until 1 year posttransplant. In case of fever above 38.3 C once or above 38 C on three consecutive measurements, empirical antibiotic therapy was started with a combination of cefepim D amikacin [29]. Patients were weekly screened for cytomegalovirus (CMV) by polymerase chain reaction (PCR).…”

Section: Clinical Managementmentioning

confidence: 99%

Pegfilgrastim compared with Filgrastim after autologous hematopoietic peripheral blood stem cell transplantation

Vanstraelen¹,

Frère²,

Ngirabacu

et al. 2006

Experimental Hematology

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Bacteremia after hematopoietic stem cell transplantation: incidence and predictive value of surveillance cultures

Cited by 45 publications

References 24 publications

Infections after allogeneic hematopoietic stem cell transplantation with a nonmyeloablative conditioning regimen

Infections after allogeneic hematopoietic stem cell transplantation with a nonmyeloablative conditioning regimen

Bacterial bloodstream infections in the allogeneic hematopoietic cell transplant patient: new considerations for a persistent nemesis

Pegfilgrastim compared with Filgrastim after autologous hematopoietic peripheral blood stem cell transplantation

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