Bacteraemic pneumococcal pneumonia and SARS-CoV-2 pneumonia: differences and similarities

Fernández, Leyre Serrano; Iturriaga, Luis Alberto Ruiz; Yandiola, Pedro Pablo España; Méndez, Raúl; Fernández, Silvia Pérez; Tabernero, Eva; Echeverría, Ane Uranga; Jimenez, Paula Gonzalez; Hontoria, Patricia Garcia; Martí, Antoni Torres; Villanueva, Rosario Menéndez; Jorge, Rafael Zalacain

doi:10.1016/j.ijid.2021.11.023

Cited by 8 publications

(8 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The role of lymphopenia as a predictor of mortality has been recognized in patients with SARS-CoV-2 pneumonia [ 21 ]. On the other hand, compared to patients with SARS-CoV-2 pneumonia, patients with bacteremic pneumococcal CAP were found to have a lower lymphocyte count on admission, even among those subsequently requiring ICU admission [ 22 ]. To our knowledge, this is the first study that has evaluated the importance of lymphopenia as a biomarker focusing on the subgroup of patients with an early diagnosis of pneumococcal pneumonia.…”

Section: Discussionmentioning

confidence: 99%

Impact of severe lymphopenia on the early prediction of clinical outcome in hospitalized patients with pneumococcal community-acquired pneumonia

et al. 2023

View full text Add to dashboard Cite

Purpose To evaluate the impact of an optimal and reproducible cutoff value set according to a predefined lymphopenia scale as an early predictor of in-hospital mortality and other outcomes in patients hospitalized with pneumococcal pneumonia and positive urinary antigen at admission to the emergency department. Methods An observational cohort study was conducted based on analysis of a prospective registry of consecutive immunocompetent adults hospitalized for pneumococcal pneumonia in two tertiary hospitals. Generalized additive models were constructed to assess the smooth relationship between in-hospital mortality and lymphopenia. Results We included 1173 patients. Lymphopenia on admission was documented in 686 (58.4%). No significant differences were observed between groups regarding the presence of comorbidities. Overall, 299 (25.5%) patients were admitted to intensive care and 90 (7.6%) required invasive mechanical ventilation. Fifty-nine (5%) patients died, among them 23 (38.9%) in the first 72 h after admission. A lymphocyte count < 500/μL, documented in 282 (24%) patients, was the predefined cutoff point that best predicted in-hospital mortality. After adjustment, these patients had higher rates of intensive care admission (OR 2.9; 95% CI 1.9–4.3), invasive mechanical ventilation (OR 2.2; 95% CI 1.2–3.9), septic shock (OR 1.8; 95% CI 1.1–2.9), treatment failure (OR 2.1; 95% CI 1.2–3.5), and in-hospital mortality (OR 2.2; 95% 1.1–4.9). Severe lymphopenia outperformed PSI score in predicting early and 30-day mortality in patients classified in the higher-risk classes. Conclusion Lymphocyte count < 500/μL could be used as a reproducible predictor of complicated clinical course in patients with an early diagnosis of pneumococcal pneumonia.

show abstract

Section: Discussionmentioning

confidence: 99%

Impact of severe lymphopenia on the early prediction of clinical outcome in hospitalized patients with pneumococcal community-acquired pneumonia

et al. 2023

View full text Add to dashboard Cite

show abstract

“…В нашей работе ключевыми клиническими признаками, отличающими ВБП от вирусного поражения лёгких были наличие озноба и снижения уровня сознания, а также отсутствие общей слабости. Эти симптомы выявлялись и по данным других исследований [6,7]. Помимо этого, для бактериальной пневмонии были характерны наличие мокроты и боли в грудной клетке [6][7][8][9].…”

Section: рис номограмма вероятности наличия у пациента с внебольнично...unclassified

“…Эти симптомы выявлялись и по данным других исследований [6,7]. Помимо этого, для бактериальной пневмонии были характерны наличие мокроты и боли в грудной клетке [6][7][8][9]. Односторонний характер инфильтрации, как признак ВБП, также описан другими исследователями [6,10,11].…”

Section: рис номограмма вероятности наличия у пациента с внебольнично...unclassified

Development of a model for the differential diagnosis of community-acquired bacterial pneumonia and viral lung injury in hospitalized adult patients

Kupriushina,

Strelkova,

Yasneva

et al. 2024

GCP

View full text Add to dashboard Cite

Relevance. During and after the COVID-19 pandemic, viruses have become a more common cause of pulmonary infections in adults; therefore, the distinction between viral lung injury and community-acquired bacterial pneumonia is of increasing importance. Aim. Development of a model for differentiating community-acquired bacterial pneumonia and viral lung injury, including COVID-19. Materials and methods. This retrospective case–control study included 300 adult patients with viral lung injury and 100 adult patients with community-acquired bacterial pneumonia. Clinical, laboratory, and instrumental data were analyzed, significant factors were selected by which the samples differed, and a model was developed using logistic regression to distinguish between community-acquired bacterial pneumonia and viral lung damage, including COVID-19. Results. The developed model included the following parameters: total protein level, neutrophil/lymphocyte index, heart rate, unilateral infiltration on CT or chest x-ray, vasopressor prescription in the first 24 h of hospitalization, altered level of consciousness, chills, and fatigue. The model had the following characteristics: AUC = 0.94 (0.92–0.96), AUC_PR = 0.84 (0.76 to 0.92), prediction accuracy — 90%, sensitivity — 76%, specificity — 95%, positive predictive value — 83 %. Conclusion. The use of this model can facilitate the differential diagnosis of community-acquired bacterial pneumonia and viral lung injury, including COVID-19, in adults in general wards and intensive care units.

show abstract

“…Patients with SARS-CoV-2 pneumonia have a higher in-hospital mortality compared to those with bacteraemic pneumococcal community-acquired pneumonia (B-PCAP). Patients requiring admission to the ICU for pneumonia are more likely to receive invasive mechanical ventilation (IMV) and have a higher mortality rate [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Coping with the hospital environment during the COVID-19 pandemic: A qualitative study of the survivors' perspective during their stay at the ICU and inpatient ward

Herrero-Montes,

Parás-Bravo,

Ferrer-Pargada

et al. 2024

Heliyon

View full text Add to dashboard Cite

Bacteraemic pneumococcal pneumonia and SARS-CoV-2 pneumonia: differences and similarities

Cited by 8 publications

References 44 publications

Impact of severe lymphopenia on the early prediction of clinical outcome in hospitalized patients with pneumococcal community-acquired pneumonia

Impact of severe lymphopenia on the early prediction of clinical outcome in hospitalized patients with pneumococcal community-acquired pneumonia

Development of a model for the differential diagnosis of community-acquired bacterial pneumonia and viral lung injury in hospitalized adult patients

Coping with the hospital environment during the COVID-19 pandemic: A qualitative study of the survivors' perspective during their stay at the ICU and inpatient ward

Contact Info

Product

Resources

About