BacScan: a novel genome-wide strategy for uncovering broadly immunogenic proteins in bacteria
Junhua Dong,
Qian Zhang,
Jinyue Yang
et al.
Abstract:In response to the global threat posed by bacterial pathogens, which are the second leading cause of death worldwide, vaccine development is challenged by the diversity of bacterial serotypes and the lack of immunoprotection across serotypes. To address this, we introduce BacScan, a novel genome-wide technology for the rapid discovery of conserved highly immunogenic proteins (HIPs) across serotypes. Using bacterial-specific serum, BacScan combines phage display, immunoprecipitation, and next-generation sequenc… Show more
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