Bacopa phospholipid complex retrieves aluminum maltolate complex–induced oxidative stress and apoptotic alterations in the brain regions of albino rat

Tirumanyam, Madhavi; Nadella, Rasajna; Kondammagari, Saritha; Borelli, Deva Prasad Raju; Nannepaga, John Sushma

doi:10.1007/s11356-019-04624-1

Cited by 7 publications

(1 citation statement)

References 51 publications

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“…The changed color of chromogen was read in the 450 nm optical range. Brain contents of IL-10 and TNF-α were expressed in picograms in 1 mg of protein [ 9 , 40 , 41 ].…”

Section: Methodsmentioning

confidence: 99%

Effect of Berberine against Cognitive Deficits in Rat Model of Thioacetamide-Induced Liver Cirrhosis and Hepatic Encephalopathy (Behavioral, Biochemical, Molecular and Histological Evaluations)

et al. 2023

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Background: Liver cirrhosis (LC) is one of the chronic liver diseases with high disability and mortality accompanying hepatic encephalopathy (HE) followed by cognitive dysfunctions. In this work, the effect of berberine (Ber) on spatial cognition was studied in a rat model of LC induced by thioacetamide (TAA). Materials and Methods: Male Wistar rats (200–250 g) were divided into six groups: (1) control; (2) TAA, 200 mg/kg/day, i.p.; (3–5) TAA + Ber; received Ber (10, 30, and 60 mg/kg, i.p., daily after last TAA injection); (6) Dizocilpine (MK-801) + TAA, received MK-801 (2 mg/kg/day, i.p.) 30 m before TAA injection. The spatial memory, BBB permeability, brain edema, liver enzymes, urea, serum and brain total bilirubin, oxidative stress and cytokine markers in the hippocampus were measured. Furthermore, a histological examination of the hippocampus was carried out. Results: The BBB permeability, brain edema, liver enzymes, urea, total bilirubin levels in serum and hippocampal MDA and TNF-α increased significantly after TAA injection (p < 0.001); the spatial memory was impaired (p < 0.001), and hippocampal IL-10 decreased (p < 0.001). Ber reversed all the above parameters significantly (p < 0.05, p < 0.01 and p < 0.001). MK-801 prevented the development of LC via TAA (p < 0.001). Conclusion: Results showed that Ber improves spatial learning and memory in TAA-induced LC by improving the BBB function, oxidative stress and neuroinflammation. Ber might be a promising therapeutic agent for cognitive improvement in LC.

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“…The changed color of chromogen was read in the 450 nm optical range. Brain contents of IL-10 and TNF-α were expressed in picograms in 1 mg of protein [ 9 , 40 , 41 ].…”

Section: Methodsmentioning

confidence: 99%

Effect of Berberine against Cognitive Deficits in Rat Model of Thioacetamide-Induced Liver Cirrhosis and Hepatic Encephalopathy (Behavioral, Biochemical, Molecular and Histological Evaluations)

et al. 2023

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Anti-migraine activity of freeze-dried latex obtained from Calotropis gigantea Linn

Bhatia

Al‐Harrasi

Kumar

et al. 2022

Environ Sci Pollut Res

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Migraine which is characterized by a pulsating headache affected an estimated population of 12% worldwide. Herbal products like latex derived from Calotropis gigantea R. Br. (Asclepiadaceae) are a representative intervention to treat migraine traditionally. However, post harvesting stability issues of latex affects its biological potential. Freeze drying has been successfully employed for the encapsulation of herbal bioactive compounds resulting in stable dried preparations. Latex derived from Calotropis gigantea (C. gigantea) was microencapsulated using chitosan by freeze-drying (FDCG) method and compared with sun rays dried latex (ADCG). Current investigation was aimed to improve the shelf life of latex by freeze drying microencapsulation technique and evaluation of its antimigraine potential. Dried latex powders (ADCG and FDCG) were evaluated in terms of phenolic content, coloring strength, rst-order kinetic, color parameters (L*, a*, b*, C* and E*), moisture, water activity, solubility and hygroscopicity. Additionally, apomorphine -induced climbing behavior, l-5-HTP induced syndrome and MK 801 induced hyperactivity were used to evaluate the antimigraine potential of powdered latex. FDCG showed good physico-chemical properties due to its higher concentration of phenolic and avonoid content. Moreover, FDCG signi cantly reduced the apomorphine -induced climbing behavior, l-5-HTP -induced syndrome and MK 801 -induced hyperactivity in a dose dependent manner through dopaminergic and serotonergic receptors interaction. In conclusion, method developed for shelf-life improvement of latex offered maximum protection over a period of 10 weeks with retaining its natural biological potential, thus it can be effectively utilized in the treatment or management of migraine.

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Evaluation of Cerebellar Function and Integrity of Adult Rats After Long-Term Exposure to Aluminum at Equivalent Urban Region Consumption Concentrations

Fernandes

Nascimento

Martins

et al. 2020

Biol Trace Elem Res

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Bacopa phospholipid complex retrieves aluminum maltolate complex–induced oxidative stress and apoptotic alterations in the brain regions of albino rat

Cited by 7 publications

References 51 publications

Effect of Berberine against Cognitive Deficits in Rat Model of Thioacetamide-Induced Liver Cirrhosis and Hepatic Encephalopathy (Behavioral, Biochemical, Molecular and Histological Evaluations)

Effect of Berberine against Cognitive Deficits in Rat Model of Thioacetamide-Induced Liver Cirrhosis and Hepatic Encephalopathy (Behavioral, Biochemical, Molecular and Histological Evaluations)

Anti-migraine activity of freeze-dried latex obtained from Calotropis gigantea Linn

Evaluation of Cerebellar Function and Integrity of Adult Rats After Long-Term Exposure to Aluminum at Equivalent Urban Region Consumption Concentrations

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