Bacopa monnieri (Linn.) Pennell - A Possible Plant for Impossible Diseases (A Review)

Abstract

Since the beginning of humankind, people are using numerous plants to cure diseases and abnormalities. Bacopa monnieri has been used by people for a long time. This plant has several medicinal and biochemical properties which would be beneficial to treat diseases. The current review article summarizes the medicinal, presence of the bioactive compound, mechanism of action, therapeutic importance, clinical trials, ethnobotanical usage, and distribution of the plant with respect to India and worldwide. Relevant information and literature on Bacopa monnieri were extracted from different sources and their finding were discussed in the manuscript. The number of therapeutic properties of the plant has been seen in the animal model experiment including anti-diarrheal, antioxidant, anti-inflammatory, anti-cancer, anti-fungal, anti-bacterial, anti-convulsant, hepatoprotective, antiulcer, anti-depressant, anti-hyperglycemic and anti-nociceptive activity, immunostimulatory activity, and wound healing activity. This article recapitulates ethnopharmacological uses of Bacopa monnieri to explore its therapeutic potentials thereby providing a basis for future research. Bacopa monnieri exhibits a comprehensive of pharmacological activities that could be observed by the presence of a vast range of chemical constituents. Manuscript also comprises tissue culture techniques and propagation of Bacopa monnieri. The study also provides a descriptive outlook on the uses of Bacopa monnieri in wastewater treatment. This review article highlights the endless possibilities present in the plant and also sheds light on research that has not yet been done on this plant and may prove useful if done in the future.

Mass propagation, Cultivation, Phytochemical and Fingerprint of Bacopa monnieri L. in Egypt

“…This result proved that the system which provided a suitable humidity environment possessed a high and early acclimatization which enhanced growth and gave high mass production. Results came in line with Pandey (2022) and Pandiyan and Selvaraj, (2012) who possessed high survival percent of hardening (96%). Plantlets were followed up until flowering in the water system and pots, but plantlets of culture mills were transplanted on the field.…”

“…It is growing in India, the Eastern Mediterranean coastal and North Sinai, Egypt (Hegazi, 2016). It is commonly used in folk medicine as an anti-aging, anti-inflammatory, anti-epileptic agent, nerve relaxing and memory enhancing, anticancer and antioxidant activities, analgesic and antipyretic (Vijay et al, 2016, Bhatia et al, 2017and Pandey, 2022. Also, Bacopa monniera contains plentiful alkaloids like brahmine, nicotine, herpestine and bacosides A, B, C and D, which are triterpenoid principles known as "Memory chemicals" (Sivaramakrishna et al, 2005).…”

“…Bacopa monnieri is used as a potent "tonic for the human brain," which utilizes as a memory enhancer. Numerous studies indicated that Bacopa contains an excess of potential bioactive, phytochemical compounds and has synergistic properties as well as helps in the management of neurological disorders, also it has anti-sickling, anti-paralytic and anti-venomous properties (Banerjee et al, 2021 andPandey, 2022). It is known that plants ordinarily protect themselves from invaders and microorganisms via the production of secondary metabolites, which generally represent miscellaneous arrays derived from alkaloid, phenylpropanoid, isoprenoid, and fatty acid/polyketide pathways (Emara et al, 2019); therefore, these are the main reasons for screening plants as potential sources for antioxidant agents.…”

Comparison of Antioxidant, Phytochemical Profiling of Bacopa monnieri (Brahmi)

“…Bacopa monnieri has a compound phenylethanoid that inhibits cancer of the lung, breast, and human colon. Its ethanolic extract is used to observe anticancer activity in different cancer cell lines its proved that the most active extract is the ethanolic extract for human breast cancer (Pandey et al, 2022).…”

Evaluation of Phytochemicals, Anti-inflammatory and Antioxidant Potential of Aegle marmelos L. Leaves

“…Both the ancient scientist scripted their knowledge in the form of books i.e. Charak Samhita and Sushruta Samhita [4,5]. These books provide the basis of Ayurveda.…”