Bacopa monnieri Ameliorates Memory Deficits in Olfactory Bulbectomized Mice: Possible Involvement of Glutamatergic and Cholinergic Systems

Le, Xoan Thi; Pham, Hang Thi Nguyet; Thi, Phuong; Fujiwara, Hironori; Tanaka, Ken; Feng, Linyin; Nguyen, Tai Van; Nguyen, Khoi Tan; Matsumoto, Kinzo

doi:10.1007/s11064-013-1129-6

Cited by 66 publications

(63 citation statements)

References 57 publications

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“…The result that OBX-induced impairment of object recognition performance was reversed by the AChE inhibitor tacrine agrees with our previous studies (8,10) and supports the idea that OBX-induced impairment of object recognition performance involves central cholinergic dysfunction (8,18).…”

Section: Discussionsupporting

confidence: 91%

“…Moreover, OBX has been used as one of the AD models since impairment of olfactory perceptual acuity is observed not only at the early stage of AD (14,15) but also in a transgenic AD model of mice over-expressing a mutant form of the human amyloid-bprecursor protein (16). In addition, OBX causes elevation of the Ab level in the brain (17) and the degeneration of septo-hippocampal cholinergic system in rodents (8,9,18), and thereby induces cognitive dysfunction (8 -10).…”

Section: Butea Superba-induced Amelioration Of Cognitive and Emotionamentioning

confidence: 99%

“…This test is based on the tendency of mice to discriminate a familiar from a new object. This test was conducted as previously described (8,9,20) with minor modification. Briefly, mice were individually habituated to an observation box (50 × 50 × 40 cm) for 10 min on the day before the experiment.…”

Section: Novel Object Recognition Test (Ort)mentioning

confidence: 99%

“…Performance of the animals in this test was video-recorded for later analysis. In these trials, the exploration of an object was defined as directing the nose to the object at a distance of < 2 cm according to previous reports (8,9,20) and the time spent exploring each of the two objects was analyzed using SMARTW ver. 2.5 (PanLab, S.L., Barcelona, Spain) with a tri-wise module to detect the head, center mass, and base tail.…”

Section: Novel Object Recognition Test (Ort)mentioning

confidence: 99%

“…Expression of synaptic plasticity-related proteins in the hippocampus was analyzed using western blotting as previously described (8,22,23). The following primary antibodies were used: anti-NMDAR1 rabbit polyclonal antibody (1:1000 dilution), anti-phospho-NMDAR1 (p-NMDAR1) (pSer896) rabbit polyclonal antibody (1:1000 dilution) (Cell Signaling Technology, Danvers, MA, USA); anti-glutamate receptor 1 (GluR1) rabbit polyclonal antibody (1:1000 dilution), anti-phoshoGluR1 (p-GluR1) (pSer 831) rabbit polyclonal antibody (1:1000 dilution) (Sigma-Aldrich); anti-CaMKIIa (A-1: sc-13141) mouse monoclonal antibody (1:1000 dilution), anti-phospho-CaMKII (p-CaMKII) (pThr286) rabbit polyclonal antibody (1:1000 dilution), anti-CREB (48H2) rabbit monoclonal antibody (1:1000 dilution), antiphospho-CREB (p-CREB) (pSer133) rabbit monoclonal antibody (1:1000 dilution), anti-choline acetyltransferase (ChAT) goat polyclonal antibody (1:5000 dilution) (AB-144P; Millipore, Temecula, CA, USA); and anti-bactin mouse monoclonal antibody (1:10,000 dilution, Abcam ® , Cambridge, UK).…”

Section: Western Blottingmentioning

confidence: 99%

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Butea superba–Induced Amelioration of Cognitive and Emotional Deficits in Olfactory Bulbectomized Mice and Putative Mechanisms Underlying Its Actions

et al. 2014

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Abstract. This study investigated the effects of alcoholic extract of Butea superba (BS) on cognitive deficits and depression-related behavior using olfactory bulbectomized (OBX) mice and the underlying molecular mechanisms of its actions. OBX mice were treated daily with BS (100 and 300 mg/kg, p.o.) or reference drugs, tacrine (2.5 mg/kg, i.p.) and imipramine (10 mg/kg, i.p.) from day 3 after OBX. OBX impaired non-spatial and spatial cognitive performances, which were elucidated by the novel object recognition test and modified Y maze test, respectively. These deficits were attenuated by tacrine and BS but not imipramine. OBX animals exhibited depressionlike behavior in the tail suspension test in a manner reversible by imipramine and BS but not tacrine. OBX down-regulated phosphorylation of synaptic plasticity-related signaling proteins: NMDA receptor, AMPA receptor, calmodulin-dependent kinase II, and cyclic AMP-responsive element-binding protein. OBX also reduced choline acetyltransferase in the hippocampus. BS and tacrine reversed these neurochemical alterations. Moreover, BS inhibited ex vivo activity of acetylcholinesterase in the brain. These results indicate that BS ameliorates not only cognition dysfunction via normalizing synaptic plasticity-related signaling and facilitating central cholinergic systems but also depression-like behavior via a mechanism differing from that implicated in BS amelioration of cognitive function in OBX animals.

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Section: Discussionsupporting

confidence: 91%

Section: Butea Superba-induced Amelioration Of Cognitive and Emotionamentioning

confidence: 99%

Section: Novel Object Recognition Test (Ort)mentioning

confidence: 99%

Section: Novel Object Recognition Test (Ort)mentioning

confidence: 99%

Section: Western Blottingmentioning

confidence: 99%

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Butea superba–Induced Amelioration of Cognitive and Emotional Deficits in Olfactory Bulbectomized Mice and Putative Mechanisms Underlying Its Actions

et al. 2014

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Herbal Drugs

Malik¹

2017

Neuroprotective Effects of Phytochemicals in Neurological Disorders

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Traditional herbal medicines to overcome stress, anxiety and improve mental health in outbreaks of human coronaviruses

Shahrajabian

Sun

Soleymani

et al. 2020

Phytotherapy Research

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Mental health condition is including depression and anxiety, and they may impact wellbeing, personal relationships and productivity of both genders. Herbal medicines have been used to treatment of anxiety and depression symptoms for centuries. SARS, MERS and COVID-19 are related to coronavirus types. SARS (sever acute respiratory syndrome, China, 2002), MERS (Middle East respiratory syndrome, Saudi Arabia, 2012), and SARS-CoV-2 (2019-2020) are the main coronavirus outbreaks. Both anxiety and depression are more serious to be considered and improved for all general public during fight with these diseases. In this mini-review article, we have mentioned the key role some of the most important plants and herbs for treatment of stress and anxiety and improve mental health against SARS and SARS-CoV-2 on the basis of traditional Asian medicine, especially traditional Chinese and Persian medicine.

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Bacopa monnieri Ameliorates Memory Deficits in Olfactory Bulbectomized Mice: Possible Involvement of Glutamatergic and Cholinergic Systems

Cited by 66 publications

References 57 publications

Butea superba–Induced Amelioration of Cognitive and Emotional Deficits in Olfactory Bulbectomized Mice and Putative Mechanisms Underlying Its Actions

Butea superba–Induced Amelioration of Cognitive and Emotional Deficits in Olfactory Bulbectomized Mice and Putative Mechanisms Underlying Its Actions

Herbal Drugs

Traditional herbal medicines to overcome stress, anxiety and improve mental health in outbreaks of human coronaviruses

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