BaCoN (Balanced Correlation Network) improves prediction of gene buffering
Thomas Rohde,
Talip Yasir Demirtas,
Angela Helen Shaw
et al.
Abstract:Buffering between genes is fundamental for robust cellular functions. While experimentally testing all possible gene pairs is infeasible, gene buffering can be predicted genome-wide under the assumption that a gene’s buffering capacity depends on its expression level and the absence of this buffering capacity primes a severe fitness phenotype of the buffered gene. We developed BaCoN (BalancedCorrelationNetwork), a post-hoc unsupervised correction method that amplifies specific signals in expression-vs-fitness … Show more
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