Abstract:The authors report an unusual case of intrathecal baclofen withdrawal due to the perforation and subsequent leakage of a baclofen pump catheter in a patient with spastic cerebral palsy. A 15-year-old boy underwent an uncomplicated placement of an intrathecal baclofen pump for the treatment of spasticity due to cerebral palsy. After excellent control of symptoms for 3 years, the patient presented to the emergency department with increasing tremors following a refill of his baclofen pump. Initial evaluat… Show more
“…An infection rate of 10% is consistent with that reported internationally 16 . All infection‐related complications occurred within 2 months of surgery.…”
Section: Discussionsupporting
confidence: 88%
“…This is likely due to prospective collection of all AEs, including mild, moderate and severe events, while most other studies have used retrospective data and report only events requiring surgical intervention 5,6 . The rate of surgical intervention required as the result of an AE (25%) for our population is consistent with AE rates described in international literature 5,6,16 …”
Aim
This study aims to examine the adverse event (AE) rate for intrathecal baclofen (ITB) therapy in an Australian paediatric population and to clarify type and frequency of AEs.
Methods
AE data were extracted from the Australian Paediatric ITB Research Group national database, to include the first 5 years of data collection. Raw data were collated and analysed descriptively.
Results
Data were collected for 40 patients. Forty‐seven AEs in 23 patients were reported. Ten (25%) patients required surgical intervention related to their AE. Five patients (12.5%) required pump removal. The most frequent ITB‐related AEs were catheter dysfunction (24%), drug overdose, withdrawal or sensitivity (19%), seromas and haematomas (15%) and infections (13%).
Conclusions
The AE rate for ITB therapy is high and needs to be considered when counselling patients regarding ITB as a therapeutic option.
“…An infection rate of 10% is consistent with that reported internationally 16 . All infection‐related complications occurred within 2 months of surgery.…”
Section: Discussionsupporting
confidence: 88%
“…This is likely due to prospective collection of all AEs, including mild, moderate and severe events, while most other studies have used retrospective data and report only events requiring surgical intervention 5,6 . The rate of surgical intervention required as the result of an AE (25%) for our population is consistent with AE rates described in international literature 5,6,16 …”
Aim
This study aims to examine the adverse event (AE) rate for intrathecal baclofen (ITB) therapy in an Australian paediatric population and to clarify type and frequency of AEs.
Methods
AE data were extracted from the Australian Paediatric ITB Research Group national database, to include the first 5 years of data collection. Raw data were collated and analysed descriptively.
Results
Data were collected for 40 patients. Forty‐seven AEs in 23 patients were reported. Ten (25%) patients required surgical intervention related to their AE. Five patients (12.5%) required pump removal. The most frequent ITB‐related AEs were catheter dysfunction (24%), drug overdose, withdrawal or sensitivity (19%), seromas and haematomas (15%) and infections (13%).
Conclusions
The AE rate for ITB therapy is high and needs to be considered when counselling patients regarding ITB as a therapeutic option.
“…In case the catheter surplus is located above the pump reservoir, refilling with medication or injecting contrast material in the catheter access port might result in catheter puncturing. Catheter perforation can result in dose adjustment problems, or even in a severe withdrawal syndrome [ 38 ]. Control identifier …”
ObjectivesIntrathecal drug administration using an implanted pump system is well established in intractable spasticity and pain. However, despite continuous advancements in manufacturing technology, adverse events related to the pump and catheter still occur. Most of them, such as migration, damage, disconnection and occlusion, are related to the spinal catheter. The aim of this overview is to update radiologists on how plain radiography of the implanted delivery system for intrathecal drug administration should be interpreted and to increase awareness for the need of urgent and timely multidisciplinary troubleshooting.MethodsPlain radiographic images of patients treated with intrathecal drug administration using an implantable drug delivery system were analysed in a multidisciplinary setting at our (university) referral centre for complications in intrathecal drug administration.ResultsExamples of catheter-related adverse events are described and a proposal is made for stepwise interpretation of standard plain radiographic images.ConclusionsPlain radiological images are the mainstay for the diagnosis of catheter-related adverse events in intrathecal drug delivery. Radiologists play an important role in an early diagnosis. An awareness of abnormal radiological findings seems important to avoid a life-threatening withdrawal syndrome.Teaching points• Untimely cessation of intrathecal drug delivery can lead to a life-threatening withdrawal syndrome.
• Initially mild symptoms can lead to an exacerbation of a withdrawal syndrome.
• Most intrathecal catheter-related problems are visible on plain radiography.
• Common causes of catheter problems are migration, lacerations, occlusion and disconnection.
• Knowledge on implanted intrathecal catheters is crucial for interpretation of plain radiography.
“…For instance the migration of the pump into the peritoneal cavity or baclofen pump pocket infection have been previously described. Children appear to be at higher risk for complications than adults [16][17][18].…”
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