Baclofen-loaded microspheres in gel suspensions for intrathecal drug delivery: In vitro and in vivo evaluation

Lagarce, Frédéric; Faisant, N.; Desfontis, Jean‐Claude; Marescaux, Laurent; Gautier, Freddy; Richard, J.; Menei, Philippe; Benoit, Jean‐Pierre

doi:10.1016/j.ejpb.2005.04.004

Cited by 42 publications

(21 citation statements)

References 36 publications

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“…The main problem is that the initial burst release is usually at undesirably high levels. For example, 20-50% of drugs will be released within 24 h in vitro release (Lagarce et al, 2005;Luzardo-Alvarez et al, 2005;Lee & Lee, 2008), and in some cases, even up to 60-70% (Al-Azzam et al, 2005;Tahara et al, 2008). Controlled-release drug delivery systems have been becoming increasingly important, especially in biomedicine, in order to achieve an optimal therapeutic level and reduce side-effects.…”

Section: Introductionmentioning

confidence: 99%

A one-step modified method to reduce the burst initial release from PLGA microspheres

Zheng

Liang

2010

Drug Delivery

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Section: Introductionmentioning

confidence: 99%

A one-step modified method to reduce the burst initial release from PLGA microspheres

Zheng

Liang

2010

Drug Delivery

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“…1,2 Various sustained release drug carriers have been made from chitosan such as microparticles, 3,4 tablets, 5,6 gel, 7,8 and beads. 9,10 Chitosan thermosensitive hydrogels prepared with different methods were of great interest in drug delivery, 11 cell encapsulation, 12 tissue engineering, 13 and so on. Dang et al 12 described thermosensitive hydroxybutyl chitosan as a biomaterial for cell encapsulation and culture.…”

Section: Introductionmentioning

confidence: 99%

Preparation of chitosan‐based thermosensitive hydrogels for drug delivery

Zhou

Chen

Kong

et al. 2009

J of Applied Polymer Sci

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The thermosensitive material that could be transformed into gel at 37 C was prepared from chitosan (dissolved in acetic acid/sodium acetate buffer solution) and a mixture of a-and b-glycerophosphate (ab-GP). The thermosensitive characteristics, appearance, and structure of the hydrogel were all affected by the pH, ionic strength, and CS/ab-GP ratio. The optimal conditions for the preparation of a transparent CS-ab-GP thermosensitive hydrogel were pH 4.6, ionic strength 0.15 mol/L, and a CS/ab-GP ratio of 8.8/1.2 (v/v). The hydrogel was stable for at least 3 months at 4 C. We believe that hydrogen bonding interactions between the NAH (and C¼ ¼O) groups of chitosan and the OAH groups of ab-GP play an important role during the process of sol-to-gel transition. The cumulative release of adriamycin from the CS-ab-GP hydrogel, measured in PBS at pH 7.4, reached only 60 to 70% over 24 h, indicating that this material could be potentially used in a sustained drug delivery system.

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“…The given anesthetic agent doses were low for rabbits in our study. Cliffer et al (17) in Sprague Dawley rats and Lagarce et al (16) in rabbits observed persistent H-reflex at supramaximal stimulus intensity. Similarly, we usually observed H-reflex at supramaximal stimulation intensities.…”

Section: Discussionmentioning

confidence: 94%

“…As an animal model the rabbit is mostly used in neurophysiological and electrophysiological studies, for instance in nerve compression studies (8)(9)(10), entrapment neuropathy studies (10-12, and neuropathic pain and nerve crush studies (13,14). In addition to these studies, the rabbit is also used in H-reflex studies (15,16). According to the authors' knowledge, the technique and results of H-reflex studies in forelimbs in rabbit have not been clarified yet.…”

Section: Introductionmentioning

confidence: 99%

H-reflex and M-wave studies in the fore- and hindlimbs of rabbit

Turan¹,

Ünsal²,

Üner³

2013

Turk J Vet Anim Sci

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The aim of this study was to investigate the H-reflex in the forelimb and to compare the forelimb and hindlimb H-reflex results and Hmax/Mmax ratios in rabbit. For this purpose, we used 15 healthy adult female New Zealand albino rabbits. Left limbs of rabbits were used for stimulation and recording procedures using general anesthesia. Electrophysiological tests were performed using Nikolet Viking Quest (USA) 2-channel EMG equipment. The median and the tibial nerves were used to evaluate H-reflex and M-waves. Latencies of the H-reflex were almost the same in both limbs. However, M-wave latencies and amplitudes were significantly different, P-values being P < 0.001 and P = 0.001, respectively. Hmax/Mmax ratios of the forelimb (0.15 ± 0.075) and the hindlimb (0.15 ± 0.068) were similar in rabbits. One possible reason for our Hmax/Mmax ratio results may be related to interspecies differences in descending pathways from red nucleus and reticular formation to cervical and lumbar spinal segments.

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Baclofen-loaded microspheres in gel suspensions for intrathecal drug delivery: In vitro and in vivo evaluation

Cited by 42 publications

References 36 publications

A one-step modified method to reduce the burst initial release from PLGA microspheres

A one-step modified method to reduce the burst initial release from PLGA microspheres

Preparation of chitosan‐based thermosensitive hydrogels for drug delivery

H-reflex and M-wave studies in the fore- and hindlimbs of rabbit

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