Backscattering of circular polarized light from a disperse random medium influenced by optical clearing

Macdonald, Callum M.; Meglinski, Igor

doi:10.1002/lapl.201010133

Cited by 38 publications

(25 citation statements)

References 27 publications

(36 reference statements)

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“…The decrease in scattering intensity can be clearly observed for higher NaCl concentrations (optical immersion agents) which are due the fact of refractive index matching effect (dehydration that is due to the osmotic characteristics of these agents, which results in water loss from the interstitial space, causing the scattering components to be tightly packed) [28], i.e., optical clearing effect (here NaCl as an agent for reducing the mismatch between fluid and PMS). Another approach for getting information from such type of dense dispersive medium like human skin is the use of circularly back scattered polarized light, i.e., tracking the polarization vectors on the Poincarè sphere [29].…”

Section: Measurement System: (Swept Source Oct)mentioning

confidence: 99%

M-mode swept source optical coherence tomography for quantification of salt concentration in blood: An in vitro study

et al. 2012

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We report the use of M mode swept source optical coherence tomography (SS OCT) for measur ing sodium chloride (NaCl) salt concentrations in liquid phantoms and in drawn whole blood based on tem poral dynamics of light scattering. The Brownian motion of scattering particle is affected due to the change in viscosity of liquid. An autocorrelation function was determined from the power spectrum of SS OCT signal and then was fit by mono and double exponential function to obtain decorrelation time. These translational decorrelation times corresponding to translational diffusion coefficients enabled us to find the controlled vis cosity of the medium. The viscosities of the media were compared with literature values and a fair/excellent agreement was observed. Thus, the technique has ability to quantify the salt levels in terms of viscosity in non flowing medium suspensions and many research routes necessary to determine its potential for in vivo appli cations.

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Section: Measurement System: (Swept Source Oct)mentioning

confidence: 99%

M-mode swept source optical coherence tomography for quantification of salt concentration in blood: An in vitro study

et al. 2012

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“…Moreover, several methods have also been applied to study the efficiency of the optical clearing technique. Examples of these studies use backscattering circular polarized light [9] and optical coherence tomography (OCT) [10].…”

Section: Introductionmentioning

confidence: 99%

The characteristic time of glucose diffusion measured for muscle tissue at optical clearing

et al. 2013

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The study of agent diffusion in biological tissues is very important to understand and characterize the optical clearing effects and mechanisms involved: tissue dehydration and refractive index matching. From measurements made to study the optical clearing, it is obvious that light scattering is reduced and that the optical properties of the tissue are controlled in the process. On the other hand, optical measurements do not allow direct determination of the diffusion properties of the agent in the tissue and some calculations are necessary to estimate those properties. This fact is imposed by the occurrence of two fluxes at optical clearing: water typically directed out of and agent directed into the tissue. When the water content in the immersion solution is approximately the same as the free water content of the tissue, a balance is established for water and the agent flux dominates. To prove this concept experimentally, we have measured the collimated transmittance of skeletal muscle samples under treatment with aqueous solutions containing different concentrations of glucose. After estimating the mean diffusion time values for each of the treatments we have represented those values as a function of glucose concentration in solution. Such a representation presents a maximum diffusion time for a water content in solution equal to the tissue free water content. Such a maximum represents the real diffusion time of glucose in the muscle and with this value we could calculate the corresponding diffusion coefficient.

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“…Thus, the circular polarization can be retained even in the diffusion regime. Note that such an effect is observed in both transmission and reflection [35,36].…”

Section: Depolarization Model and Basic Relationshipsmentioning

confidence: 90%

Imaging through turbid media by polarized light

et al. 2012

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A theoretical approach to the calculation of the image of an inhomogeneity in transillumination of tissue like media using polarized radiation is developed in the approximation of the basic polarization modes. The method is based on the solution of the nonstationary transfer equation in the Fokker-Planck approximation. An expression for the edge spread function of the image of a totally absorbing half plane is derived. A generalization to the image profile of inhomogeneity that represents a finite width stripe is pre sented. The spatial resolution (sharpness) and contrast of image are analyzed at various time intervals of detection. The image parameters are compared for the polarization difference technique and imaging in unpolarized light. It is demonstrated that the imaging using the difference of linear polarizations is similar to the imaging using the pulsed unpolarized radiation with a detection interval of about z/2c (z is the thickness of the sample and c is the velocity of light). The results are in agreement with the experimental data on the differential polarization transillumination of tissue like media.

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Backscattering of circular polarized light from a disperse random medium influenced by optical clearing

Cited by 38 publications

References 27 publications

M-mode swept source optical coherence tomography for quantification of salt concentration in blood: An in vitro study

M-mode swept source optical coherence tomography for quantification of salt concentration in blood: An in vitro study

The characteristic time of glucose diffusion measured for muscle tissue at optical clearing

Imaging through turbid media by polarized light

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