Back to the future (of common respiratory viruses)

Mattana, Giordana; Albitar-Nehme, Sami; Cento, Valeria; Colagrossi, Luna; Piccioni, Livia; Raponi, Massimiliano; Raucci, Umberto; Vittucci, Anna Chiara; Reale, Antonino; Villani, Alberto; Bernaschi, Paola; Perno, Carlo Federico

doi:10.1016/j.jgar.2022.01.010

Cited by 17 publications

(16 citation statements)

References 4 publications

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“… 8 , 9 , 10 Various studies have reported a marked increase in the incidence of different diseases in 2021, supporting the relevance of the concept of immunity debt for RSV and enterovirus. 8 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 …”

Section: Introductionmentioning

confidence: 99%

Trends in pediatric ambulatory community acquired infections before and during COVID-19 pandemic: A prospective multicentric surveillance study in France

Cohen

Rybak

Werner

et al. 2022

The Lancet Regional Health - Europe

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Section: Introductionmentioning

confidence: 99%

Trends in pediatric ambulatory community acquired infections before and during COVID-19 pandemic: A prospective multicentric surveillance study in France

Cohen

Rybak

Werner

et al. 2022

The Lancet Regional Health - Europe

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“…Although the etiology of ARI is complicated, some common respiratory viruses have been reported as the leading causes of the disease [ 1 , 2 , 28 ]. One constant feature of the northern hemisphere’s winter months is the circulation of influenza viruses, leading to seasonal epidemics.…”

Section: Discussionmentioning

confidence: 99%

“…The dissemination of SARS-CoV-2 in the last two years has profoundly influenced the incidence of respiratory affections, altering epidemiological curves of other pathogens, both in pediatric and adult populations [ 1 , 2 , 3 ]. Therefore, the possibility to recognize which microorganism (Influenza A and B viruses, Respiratory Syncytial Virus, Parainfluenza viruses) is the cause of respiratory diseases, namely Acute Respiratory Infections (ARIs), is essential for monitoring and curing patients, defining therapeutic decisions, and finding adequate public health strategies [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Infection Rate of Respiratory Viruses in the Pandemic SARS-CoV-2 Period Considering Symptomatic Patients: Two Years of Ongoing Observations

et al. 2022

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Background: In the last two years, the SARS-CoV-2 pandemic has determined radical changes in human behaviors and lifestyles, with a drastic reduction in socialization due to physical distancing and self-isolation. These changes have also been reflected in the epidemiological patterns of common respiratory viruses. For this reason, early discrimination of respiratory viruses is important as new variants emerge. Methods: Nasopharyngeal swabs of 2554 patients, with clinically suspected Acute Respiratory Infections (ARIs) from October 2019 to November 2021, were collected to detect 1 or more of the 23 common respiratory pathogens, especially viruses, via BioFilmArray RP2.1plus, including SARS-CoV-2. Demographical characteristics and epidemiological analyses were performed as well as a laboratory features profile of positive patients. Results: An observational study on 2300 patients (254 patients were excluded because of missing data) including 1560 men and 760 women, median age of 64.5 years, was carried out. Considering the respiratory virus research request, most of the patients were admitted to the Emergency Medicine Department (41.2%, of patients), whereas 29.5% were admitted to the Infectious Diseases Department. The most frequently detected pathogens included SARS-CoV-2 (31.06%, 707/2300, from March 2020 to November 2021), InfA-B (1.86%, 43/2300), HCoV (2.17% 50/2300), and HSRV (1.65%, 38/2300). Interestingly, coinfection rates decreased dramatically in the SARS-CoV-2 pandemic period. The significative decrease in positive rate of SARS-CoV-2 was associated with the massive vaccination. Conclusion: This study represents a dynamic picture of the epidemiological curve of common respiratory viruses during the two years of pandemic, with a disregarded trend for additional viruses. Our results showed that SARS-CoV-2 had a preferential tropism for the respiratory tract without co-existing with other viruses. The possible causes were attributable either to the use of masks, social isolation, or to specific respiratory receptors mostly available for this virus, external and internal lifestyle factors, vaccination campaigns, and emergence of new SARS-CoV-2 variants.

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“…The important reduction of pediatric respiratory hospitalisations, virtual absence of influenza and RSV during first pandemic year and increased role of COVID-19 and ORV, especially RSV, in hospitalised children during second pandemic year in our study are in line with reports from some other countries and other provinces of Canada (13,16,17,29,30). Of note, the timing of the unusual surge of RSV varied by region of the world: in Europe, Israel and USA increases started to be reported in the Spring-Summer of 2021(13,16,17,29). Major shifts in the epidemiology of RSV with large-scale outbreaks were reported in New Zealand (corresponding to usual season)(31) and Australia (out-of-season)(32).…”

Section: Discussionmentioning

confidence: 99%

“…However, because of high demand of SARS-CoV-2 tests on hospital laboratories, the testing for ORV has been reduced even in hospitalised patients during the pandemic. A number of reports described detection of ORV in patients hospitalised with ARI or with COVID-19 during the pandemic (8,(15)(16)(17)(18)(19). However, to our knowledge none described results of systematic detection of both ORV and SARS-CoV-2 (not only at physician request) using a panel of multiple RV in a multicenter network including both pandemic years and comparing them with as long as 8 pre-pandemic years.…”

Section: Introductionmentioning

confidence: 99%

The changing landscape of respiratory viruses contributing to respiratory hospitalisations: results from a hospital-based surveillance in Quebec, Canada, 2012-13 to 2021-22

Gilca

Amini

Carazo

et al. 2022

Preprint

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Background. A comprehensive description of the combined effect of SARS-CoV-2 and respiratory viruses (RV) other than SARS-CoV-2 (ORV) on hospitalisations is lacking. Aim. To compare viral etiology of acute respiratory infections (ARI) hospitalisations before and during two pandemic years from a surveillance network in Quebec, Canada. Method. We compared detection of ORV and SARS-CoV-2 during 2020-21 and 2021-22 to 8 pre-pandemic influenza seasons in patients hospitalised with ARI who were tested systematically by a multiplex PCR. Results. During pre-pandemic influenza seasons, overall RV detection was 92.7% (1,493) (48.3% respiratory syncytial virus (RSV)) in children and 62.8% (4,339) (40.1% influenza) in adults. Overall RV detection in 2020-21 was 58.6% (29) in children (all ORV) and 43.7% (333) in adults (3.4% ORV, 40.3% SARS-CoV2, both including coinfections). In 2021-22 overall RV detection was 91.0% (201) in children (82.8% ORV, 8.1% SARS-CoV-2, both including coinfections) and 55.5% (527) in adults (14.1% ORV, 41.4% SARS-CoV-2, both including coinfections). Virtually no influenza was detected in 2020-21 and in 2021-22 up to epi-week 2022-9 presented here; no RSV was detected in 2020-21. In 2021-22, detection of RSV was comparable to pre-pandemic years but with an unusually early season. There were significant differences in ORV and SARS-CoV-2 detection between time periods and age groups. Conclusion. Significant continuous shifts in age distribution and viral etiology of ARI hospitalisations occurred during two pandemic years. This reflects evolving RV epidemiology and underscores the need for increased scrutiny of ARI hospitalisation etiology to inform tailored public health recommendations.

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Back to the future (of common respiratory viruses)

Cited by 17 publications

References 4 publications

Trends in pediatric ambulatory community acquired infections before and during COVID-19 pandemic: A prospective multicentric surveillance study in France

Trends in pediatric ambulatory community acquired infections before and during COVID-19 pandemic: A prospective multicentric surveillance study in France

Infection Rate of Respiratory Viruses in the Pandemic SARS-CoV-2 Period Considering Symptomatic Patients: Two Years of Ongoing Observations

The changing landscape of respiratory viruses contributing to respiratory hospitalisations: results from a hospital-based surveillance in Quebec, Canada, 2012-13 to 2021-22

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