Abstract:SUMMARYWe present the case of a 14-year-old previously healthy boy who presented to his general practitioner with back pain and fever after rugby training. He was initially treated for suspected discitis but during the course of his admission he rapidly deteriorated and developed severe necrotising pneumonia. He was intubated, ventilated and transferred to a paediatric intensive care unit. Panton-Valentine leukocidin Staphylococcus aureus was suspected and subsequently identified in blood cultures.
BACKGROUND
“…Since 2010, we have identified 15 reported cases of paediatric PVL-SA severe infections and Table 1 summarizes the main results of these reports regarding the clinical presentations, radiological findings, treatment and outcome [2][3][4][5][15][16][17][18][19][20][21][22][23].…”
Section: Discussionmentioning
confidence: 99%
“…Redness of left foot. Large osteomyelitis of left tibia with intramedullary abscesses and significant edema of surrounding muscles (MRI) Intravenous flucloxacillin and gentamicin MRSA genotype not clarified Four weeks of intravenous antibiotics, follow by 4 weeks of oral antibiotic (not clarified) Recurrent surgical drainage (5 times) Sever restriction of the motion the left ankle Haider, 2013, United Kingdom [ 3 ] 1 12-years, M Sore throat, fever, haemoptysis, progressive respiratory failure Extensive bilateral alveolar pulmonary shadowing (chest X-ray) Intravenous cefuroxime Not clarified if MSSA or MRSA Not clarified No surgical treatment Death Fitzgerald, 2013, United Kingdom [ 17 ] 1 14-years, M Fever, back pain (after rugby training), follow by severe necrotizing pneumonia Discitis and peridural abscess at L3-L4 (MRI). Bilateral interstitial infiltrates (chest X-ray) Intravenous flucloxacillin and clindamycin, followed by ceftriaxone, clindamycin, clarithromycin and linezolid MSSA genotype not clarified After 7 days he was treated with intravenous ceftriaxone and oral clindamycin for 3 months No surgical treatment.…”
Section: Discussionmentioning
confidence: 99%
“…Generally, a long duration antibiotic therapy is usually needed, in particular in complicated cases [ 17 ]. Unfortunately, antibiotic treatment alone is often insufficient, as antibiotic distribution is reduced in necrotic tissue.…”
Background
Panton-Valentine leukocidin (PVL) is one of the major virulence factor of Staphylococcus aureus (SA) that might be associated with invasive life-threating infections. A prompt diagnosis and adequate treatment are essential in achieving the best outcome and avoiding serious sequelae. We describe a case of severe invasive PVL-SA infection in an infant. A literature review starting from 2010 was also performed in order to discuss clinical presentations, radiological findings, treatment and outcome.
Case presentation
This is a case of a 6-month-old boy who rapidly developed high fever and poor general condition. He was diagnosed as having multiple muscular abscesses, multiple foci of osteomyelitis and bloodstream infections caused by Panton-Valentine leukocidin Methicillin-resistant Staphylococcus aureus. He received intravenous antibiotics and surgical drainage of the abscess with progressive recovery.
Conclusion
Our report highlights the importance of improving awareness of this severe infection, as a prompt diagnosis and adequate manage is essential in order to save life and to prevent serious complications.
“…Since 2010, we have identified 15 reported cases of paediatric PVL-SA severe infections and Table 1 summarizes the main results of these reports regarding the clinical presentations, radiological findings, treatment and outcome [2][3][4][5][15][16][17][18][19][20][21][22][23].…”
Section: Discussionmentioning
confidence: 99%
“…Redness of left foot. Large osteomyelitis of left tibia with intramedullary abscesses and significant edema of surrounding muscles (MRI) Intravenous flucloxacillin and gentamicin MRSA genotype not clarified Four weeks of intravenous antibiotics, follow by 4 weeks of oral antibiotic (not clarified) Recurrent surgical drainage (5 times) Sever restriction of the motion the left ankle Haider, 2013, United Kingdom [ 3 ] 1 12-years, M Sore throat, fever, haemoptysis, progressive respiratory failure Extensive bilateral alveolar pulmonary shadowing (chest X-ray) Intravenous cefuroxime Not clarified if MSSA or MRSA Not clarified No surgical treatment Death Fitzgerald, 2013, United Kingdom [ 17 ] 1 14-years, M Fever, back pain (after rugby training), follow by severe necrotizing pneumonia Discitis and peridural abscess at L3-L4 (MRI). Bilateral interstitial infiltrates (chest X-ray) Intravenous flucloxacillin and clindamycin, followed by ceftriaxone, clindamycin, clarithromycin and linezolid MSSA genotype not clarified After 7 days he was treated with intravenous ceftriaxone and oral clindamycin for 3 months No surgical treatment.…”
Section: Discussionmentioning
confidence: 99%
“…Generally, a long duration antibiotic therapy is usually needed, in particular in complicated cases [ 17 ]. Unfortunately, antibiotic treatment alone is often insufficient, as antibiotic distribution is reduced in necrotic tissue.…”
Background
Panton-Valentine leukocidin (PVL) is one of the major virulence factor of Staphylococcus aureus (SA) that might be associated with invasive life-threating infections. A prompt diagnosis and adequate treatment are essential in achieving the best outcome and avoiding serious sequelae. We describe a case of severe invasive PVL-SA infection in an infant. A literature review starting from 2010 was also performed in order to discuss clinical presentations, radiological findings, treatment and outcome.
Case presentation
This is a case of a 6-month-old boy who rapidly developed high fever and poor general condition. He was diagnosed as having multiple muscular abscesses, multiple foci of osteomyelitis and bloodstream infections caused by Panton-Valentine leukocidin Methicillin-resistant Staphylococcus aureus. He received intravenous antibiotics and surgical drainage of the abscess with progressive recovery.
Conclusion
Our report highlights the importance of improving awareness of this severe infection, as a prompt diagnosis and adequate manage is essential in order to save life and to prevent serious complications.
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