Back, Lower Limb, and Upper Limb Pain Among U.S. Adults, 2019

Lucas, Jacqueline W.; Connor, Eric M.; Bose, Jonaki

doi:10.15620/cdc:107894

Cited by 33 publications

(25 citation statements)

References 5 publications

(10 reference statements)

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“…According to the CDC, lower extremity pain is the second most common cause of pain, affecting nearly one-third of all patients [ 18 ]. Unfortunately, when left untreated, patients with lower extremity pain are at risk for musculoskeletal impairment, diminished quality of life, and increasing health care costs.…”

Section: Etiology and Epidemiology Of Lower Extremity Painmentioning

confidence: 99%

“…Unfortunately, when left untreated, patients with lower extremity pain are at risk for musculoskeletal impairment, diminished quality of life, and increasing health care costs. Notably, these findings disproportionately affect individuals coming from lower socioeconomic backgrounds and adults older than 65 [ 18 ]. Thus, the development of effective treatment modalities for lower extremity pain is also a matter of healthcare equality.…”

Section: Etiology and Epidemiology Of Lower Extremity Painmentioning

confidence: 99%

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Peripheral Nerve Stimulation for Lower Extremity Pain

et al. 2022

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Peripheral nerve stimulation (PNS) is rapidly increasing in use. This interventional pain treatment modality involves modulating peripheral nerves for a variety of chronic pain conditions. This review evaluated its use specifically in the context of chronic lower extremity pain. Studies continue to elucidate the utility of PNS and better define indications, contraindications, as well as short- and long-term benefits of the procedure for the lower extremity. While large, prospective evidence is still lacking, the best available evidence suggests that improvements may be seen in pain scores, functionality, and opioid consumption. Overall, evidence synthesis suggests that PNS for the lower extremities may be a viable option for patients with chronic lower extremity pain.

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Section: Etiology and Epidemiology Of Lower Extremity Painmentioning

confidence: 99%

Section: Etiology and Epidemiology Of Lower Extremity Painmentioning

confidence: 99%

Peripheral Nerve Stimulation for Lower Extremity Pain

et al. 2022

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“…The intersection between pain and opioid abuse presents a major dilemma for public health. Over half of US adults report having pain 1 , which is a primary source of motivation for opioid misuse 2 . Opioid pain medications are potent analgesics commonly used to treat pain symptoms but are highly prone to abuse.…”

Section: Introductionmentioning

confidence: 99%

Time-dependent enhancement in ventral tegmental area dopamine neuron activity drives pain-facilitated fentanyl intake in males

Higginbotham

Abt

Teich

et al. 2022

Preprint

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Pain affects over 50% of US adults. Opioids are potent analgesics used to treat pain symptoms but are highly prone to abuse, creating a major dilemma for public health. Evidence suggests that the proclivity for opioid abuse under pain conditions varies between sexes. However, the neural mechanisms underlying sex-specific effects of pain on opioid use are largely unclear. Here, we recapitulate clinical findings and demonstrate that pain increases self-administration of the widely abused opioid, fentanyl, selectively in male rats. These behavioral effects develop over time and are paralleled by sex- and pain-specific effects on fentanyl-evoked ventral tegmental area (VTA) dopamine (DA) neuron activity, a critical mediator of motivation and reward. Using in vivo fiber photometry, we show that tonic VTA DA neuron activity is attenuated in males with pain. In contrast, phasic VTA DA neuron responses to self-administered fentanyl increase in magnitude at later timepoints and correspond with increases in fentanyl intake. The protracted increase in fentanyl-evoked VTA DA activity is necessary for pain to enhance fentanyl self-administration in males because chemogenetic inhibition of VTA DA neurons normalized fentanyl intake and associated fentanyl-evoked VTA DA neuron responses. These findings reveal time-dependent and sex-specific pain-induced adaptations to VTA DA neuron function that underlie maladaptive patterns of opioid use.

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“…The rates of back pain, neck pain, and other MSK disorders in the United States are among the highest in the world [ 1 ]. In 2019, 39% of American adults reported back pain, 37% reported lower limb pain (eg, hips, knees, and feet), and 31% reported upper limb pain (eg, hands, arms, and shoulders) in the 3 months prior [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical Outcomes After a Digital Musculoskeletal Program for Acute and Subacute Pain: Observational, Longitudinal Study With Comparison Group

Wang¹,

Yang²,

Hong³

et al. 2022

JMIR Rehabil Assist Technol

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Background Telerehabilitation for musculoskeletal (MSK) conditions may produce similar or better outcomes than usual care, but most telerehabilitation studies address only chronic or postsurgical pain. Objective We aimed to examine pain and function at 3, 6, and 12 weeks for individuals with acute and subacute MSK pain who took part in a digital MSK program versus a nonparticipant comparison group. Methods We conducted an observational, longitudinal study with a nonparticipant comparison group. The intervention group had video visits with physical therapists who recommended exercise therapies and educational articles delivered via an app. Nonparticipants were those who were registered but unable to participate because their benefit coverage had not yet begun. We collected pain and function outcomes through surveys delivered at 3-, 6-, and 12-week follow-ups. We conducted descriptive analyses, unadjusted regression, and mixed effects regression adjusting for baseline characteristics, time as fixed effects, and a time*group interaction term. Results The analysis included data from 675 nonparticipants and 262 intervention group participants. Compared to baseline, the intervention group showed significantly more pain improvement at 3, 6, and 12 weeks versus nonparticipants after adjusting for baseline factors. Specifically, the intervention group’s pain scores decreased by 55.8% at 3 weeks versus baseline, 69.1% at 6 weeks, and 73% at 12 weeks. The intervention group’s adjusted pain scores decreased from 43.7 (95% CI 41.1-46.2) at baseline to 19.3 (95% CI 16.8-21.8) at 3 weeks to 13.5 (95% CI 10.8-16.2) at 6 weeks to 11.8 (95% CI 9-14.6) at 12 weeks. In contrast, nonparticipants’ pain scores decreased by 30.8% at 3 weeks versus baseline, 45.8% at 6 weeks, and 46.7% at 12 weeks. Nonparticipants’ adjusted pain scores decreased from 43.8 (95% CI 42-45.5) at baseline to 30.3 (95% CI 27.1-33.5) at 3 weeks to 23.7 (95% CI 20-27.5) at 6 weeks to 23.3 (95% CI 19.6-27) at 12 weeks. After adjustments, the percentage of participants reporting that pain was better or much better at follow-up was significantly higher by 40.6% at 3 weeks, 31.4% at 6 weeks, and 31.2% at 12 weeks for intervention group participants versus nonparticipants. After adjustments, the percentage of participants with meaningful functional improvement at follow-up was significantly higher by 15.2% at 3 weeks and 24.6% at 12 weeks for intervention group participants versus nonparticipants. Conclusions A digital MSK program may help to improve pain and function in the short term among those with acute and subacute MSK pain.

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Back, Lower Limb, and Upper Limb Pain Among U.S. Adults, 2019

Abstract: This report provides national estimates of any pain regardless of body region as well as estimates of back, upper limb (hips, knees, or feet) pain in the past 3 months among U.S. adults aged 18 and over by selected sociodemographic characteristics.

Cited by 33 publications

References 5 publications

Peripheral Nerve Stimulation for Lower Extremity Pain

Peripheral Nerve Stimulation for Lower Extremity Pain

Time-dependent enhancement in ventral tegmental area dopamine neuron activity drives pain-facilitated fentanyl intake in males

Clinical Outcomes After a Digital Musculoskeletal Program for Acute and Subacute Pain: Observational, Longitudinal Study With Comparison Group

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