Back Cover: A Click Chemistry‐Based Artificial Metallo‐Nuclease (Angew. Chem. Int. Ed. 38/2023)

Abstract

An ew click chemistry ……g enerated artificial metallonuclease is reported in the Research Article by Andrew Kellett et al. (e202305759). Theo xidative DNAd amaging properties of ap olynuclear copper binding ligand called TC-Thio is demonstrated. Copper-TC-Thio binds in the minor groove of genomic DNAa nd promotes damage via as uperoxide linked mechanism. Theinset picture shows copper ions,bound to the TC-Thio ligand, melting into the DNAd uplex and filling the reaction chamber with molten liquid DNA.