“…Prontosil 1936, 19351942(Lesch, 2007Simon, 2011) Sulfamethoxazole 1961 1960 (Akiba et al, 1960;Stamm and Hooton, 1993;Andrew, 2013) Tetracyclines Protein biosynthesis inhibition Tetracycline 1950 1959 (Ramsey and Edwards, 1961;Fischer et al, 2010) Macrolide Erythromycin 1953 1956 (Finland et al, 1956) Azithromycin 1980 2011 (Soge et al, 2012) Oxazolidinones Linezolid 2000 2001 (Tsiodras et al, 2001;Li and Corey, 2013;Török et al, 2016 (Weinberg, 1967;Mary, 2007) Aztreonam 1984, 19861986(Res et al, 2017 Imipenem 1985 1996 (Troillet et al, 1997;Fischer et al, 2010) Lincosamides Interfering with the synthesis of proteins Clindamycin 1966 1971 (Watanakunakorn, 1976;Troillet et al, 1997) daily doses) during 2000 to 2015, which was mainly driven by low-and middle-income countries) (Klein et al, 2018). Recently, Klein et al, used an indicator (Drug Resistance Index, DRI) to elucidate the effectiveness of antibiotic therapy by combining antibiotic consumption and resistance (Klein et al, 2019).…”