Bacillus sp.: A Remarkable Source of Bioactive Lipopeptides

Théatre, Ariane; Hoste, Alexis C. R.; Rigolet, Augustin; Benneceur, I; Béchet, Max; Ongena, Marc; Deleu, Magali; Jacques, Philippe

doi:10.1007/10_2021_182

Cited by 15 publications

(8 citation statements)

References 327 publications

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“…This machinery gives rise to a large chemical diversity with different structures, based on their amino acid sequence or on the length of the fatty acid chain. These metabolites are classified into the heptapeptides surfactins (pumilacidins/lichenisins) and iturins (iturin A, mycosubtilin, bacillomycin) and the decapeptides fengycins (plipastatins); together with their homologues of different alkyl chain lengths (C 12 - C 17 for surfactins, C 13 -C 17 for iturins and C 14 -C 18 for fengycins) ( Théatre et al., 2022 ). They are produced by members of the Bacillus subtilis group and are known to be involved in the induction of resistance in plants ( Pršić and Ongena, 2020 ; Dimkić et al., 2022 ; Mahapatra et al., 2022 ) and, thanks to their amphiphilic nature, exhibit antimicrobial activities against a wide range of pathogenic microorganisms by penetrating and disrupting the cell membrane of target organisms ( Fira et al., 2018 ; Ngalimat et al., 2021 ; Puan et al., 2023 ).…”

Section: Bacillus As Successful Pgpr For Biological Controlmentioning

confidence: 99%

Bacillus-based biocontrol beyond chemical control in central Africa: the challenge of turning myth into reality

Nihorimbere,

Korangi Alleluya,

Nimbeshaho

et al. 2024

Front. Plant Sci.

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Agricultural productivity in the Great Lakes Countries of Central Africa, including Burundi, Rwanda, and the Democratic Republic of Congo, is affected by a wide range of diseases and pests which are mainly controlled by chemical pesticides. However, more than 30% of the pesticides used in the region are banned in European Union due to their high toxicity. Globally available safe and eco-friendly biological alternatives to chemicals are virtually non-existent in the region. Bacillus PGPR-based biocontrol products are the most dominant in the market and have proven their efficacy in controlling major plant diseases reported in the region. With this review, we present the current situation of disease and pest management and urge the need to utilize Bacillus-based control as a possible sustainable alternative to chemical pesticides. A repertoire of strains from the Bacillus subtilis group that have shown great potential to antagonize local pathogens is provided, and efforts to promote their use, as well as the search for indigenous and more adapted Bacillus strains to local agro-ecological conditions, should be undertaken to make sustainable agriculture a reality in the region.

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Section: Bacillus As Successful Pgpr For Biological Controlmentioning

confidence: 99%

Bacillus-based biocontrol beyond chemical control in central Africa: the challenge of turning myth into reality

Nihorimbere,

Korangi Alleluya,

Nimbeshaho

et al. 2024

Front. Plant Sci.

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“…Daptomycin has been approved by the Food and Drug Administration (FDA) for the treatment of infections caused by Grampositive bacteria, with the market name of Cubicin [4]. In addition, since the FDA approved cilofungin, micafungin, and anidulafungin for the treatment of fungal infections in 2001, 2005, and 2006, respectively, more and more fungi lipopeptides and their chemically synthesized derivatives have been developed into commercial products or subjected to clinical trials, including caspofungin, rezafungin, emodepside, fusafungine and destruxins [3,6]. Consequently, it is of great importance to undertake further investigation of lipopeptides.…”

Section: Introductionmentioning

confidence: 99%

Strategies for improving fengycin production: a review

Yin,

Wang,

Zhang

et al. 2024

Microb Cell Fact

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Fengycin is an important member of the lipopeptide family with a wide range of applications in the agricultural, food, medical and cosmetic industries. However, its commercial application is severely hindered by low productivity and high cost. Therefore, numerous studies have been devoted to improving the production of fengycin. We summarize these studies in this review with the aim of providing a reference and guidance for future researchers. This review begins with an overview of the synthesis mechanism of fengycin via the non-ribosomal peptide synthetases (NRPS), and then delves into the strategies for improving the fengycin production in recent years. These strategies mainly include fermentation optimization and metabolic engineering, and the metabolic engineering encompasses enhancement of precursor supply, application of regulatory factors, promoter engineering, and application of genome-engineering (genome shuffling and genome-scale metabolic network model). Finally, we conclude this review with a prospect of fengycin production.

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“…Surfactin is a promising bio-surfactant suitable for high temperature conditions required in industrial applications [5] , [6] , [7] , [8] , [9] , [10] . It is a lipopeptide produced by several strains of the genus Bacillus [11] with a wide range of applications in industry, agriculture, and medicine, such as emulsifiers, dispersants, and biocontrol agents [12] , [13] , [14] , [15] .…”

Section: Introductionmentioning

confidence: 99%

Optimisation of surfactin yield in Bacillus using data-efficient active learning and high-throughput mass spectrometry

Albornoz,

Oyarzún,

Burgess

2024

Computational and Structural Biotechnology Journal

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Bacillus sp.: A Remarkable Source of Bioactive Lipopeptides

Cited by 15 publications

References 327 publications

Bacillus-based biocontrol beyond chemical control in central Africa: the challenge of turning myth into reality

Bacillus-based biocontrol beyond chemical control in central Africa: the challenge of turning myth into reality

Strategies for improving fengycin production: a review

Optimisation of surfactin yield in Bacillus using data-efficient active learning and high-throughput mass spectrometry

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