Bacillus pumilus of Palk Bay origin inhibits quorum-sensing-mediated virulence factors in Gram-negative bacteria

Nithya, C.; Aravindraja,; Pandian, Shunmugiah Karutha

doi:10.1016/j.resmic.2010.03.002

Cited by 109 publications

(60 citation statements)

References 38 publications

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“…3a-c. The inhibition of prodigiosin, protease enzyme and hemolysin production by the sponge extracts observed in the present study falls in line with the previous studies with bacterial extracts [10,19].…”

Section: Discussionsupporting

confidence: 93%

Inhibition of Quorum Sensing Mediated Virulence Factors Production in Urinary Pathogen Serratia marcescens PS1 by Marine Sponges

et al. 2012

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The focal intent of this study was to find out an alternative strategy for the antibiotic usage against bacterial infections. The quorum sensing inhibitory (QSI) activity of marine sponges collected from Palk Bay, India was evaluated against acyl homoserine lactone (AHL) mediated violacein production in Chromobacterium violaceum (ATCC 12472), CV026 and virulence gene expressions in clinical isolate Serratia marcescens PS1. Out of 29 marine sponges tested, the methanol extracts of Aphrocallistes bocagei (TS 8), Haliclona (Gellius) megastoma (TS 25) and Clathria atrasanguinea (TS 27) inhibited the AHL mediated violacein production in C. violaceum (ATCC 12472) and CV026. Further, these sponge extracts inhibited the AHL dependent prodigiosin pigment, virulence enzymes such as protease, hemolysin production and biofilm formation in S. marcescens PS1. However, these sponge extracts were not inhibitory to bacterial growth, which reveals the fact that the QSI activity of these extracts was not related to static or killing effects on bacteria. Based on the obtained results, it is envisaged that the marine sponges could pave the way to prevent quorum sensing (QS) mediated bacterial infections.

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Section: Discussionsupporting

confidence: 93%

Inhibition of Quorum Sensing Mediated Virulence Factors Production in Urinary Pathogen Serratia marcescens PS1 by Marine Sponges

et al. 2012

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“…Hence, inhibition of prodigiosin will reduce the pathogenicity of S. marcescens. Prodigiosin inhibition is previously reported with natural products [47] and bacterial supernatant [48] but this is probably the first report on zinc nanoparticle impairing prodigiosin production in S. marcescens.…”

Section: Effect On Prodigiosin Production Of S Marcescensmentioning

confidence: 72%

Biofabrication of Zinc Oxide Nanoparticle fromOchradenus baccatusLeaves: Broad-Spectrum Antibiofilm Activity, Protein Binding Studies, andIn VivoToxicity and Stress Studies

Al‐Shabib

Husain

Hassan

et al. 2018

Journal of Nanomaterials

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Biofilms are complex aggregation of cells that are embedded in EPS matrix. These microcolonies are highly resistant to drugs and are associated with various diseases. Biofilms have greatly affected the food safety by causing severe losses due to food contamination and spoilage. Therefore, novel antibiofilm agents are needed. This study investigates the antibiofilm and protein binding activity of zinc nanoparticles (ZnNPs) synthesized from leaf extract of Ochradenus baccatus. Standard physical techniques, including UVvisible spectroscopy Fourier transform infrared spectroscopy and X-ray diffraction and transmission electron microscopy, were used to characterize the synthesized OB-ZnNPs. Synthesized OB-ZnNPs demonstrated significant biofilm inhibition in human and food-borne pathogens (Chromobacterium violaceum, Escherichia coli, P. aeruginosa, Klebsiella pneumoniae, Serratia marcescens, and Listeria monocytogenes) at subinhibitory concentrations. OB-ZnNPs significantly reduced the virulence factors like violacein, prodigiosin, and alginate and impaired swarming migration and EPS production. OB-ZnNPs demonstrated efficient binding with HSA protein and no change in their structure or stability was observed. In addition, in vivo toxicity evaluation confirmed that OBZnNPs possessed no serious toxic effect even at higher doses. Moreover, they were found to have excellent antioxidant properties that can be employed in the fields of food safety and medicine. Hence, it is envisaged that the OB-ZnNPs can be used as potential nanomaterials to combat drug resistant bacterial infections and prevent contamination/spoilage of food.

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“…Bacteria from marine environment are known for their rich source of bioactive molecules, but the reports are scanty for their antibiofilm metabolites (Thenmozh et al, 2011;Bakkiyaraj and Pandian, 2010;Nithya et al, 2010). Moreover, several studies suggest many marine bacteria are capable of producing novel antibiofilm compound(s) …”

Section: Bacteriocin Activitymentioning

confidence: 99%

Chemical characterization and bioactivity evaluation of bacteriocin from marine biofilm-forming bacteria

Sengol¹,

Balasubramanian²,

Rajendran³

2014

Afr. J. Microbiol. Res.

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Bacillus pumilus of Palk Bay origin inhibits quorum-sensing-mediated virulence factors in Gram-negative bacteria

Cited by 109 publications

References 38 publications

Inhibition of Quorum Sensing Mediated Virulence Factors Production in Urinary Pathogen Serratia marcescens PS1 by Marine Sponges

Inhibition of Quorum Sensing Mediated Virulence Factors Production in Urinary Pathogen Serratia marcescens PS1 by Marine Sponges

Biofabrication of Zinc Oxide Nanoparticle fromOchradenus baccatusLeaves: Broad-Spectrum Antibiofilm Activity, Protein Binding Studies, andIn VivoToxicity and Stress Studies

Chemical characterization and bioactivity evaluation of bacteriocin from marine biofilm-forming bacteria

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