Bacillus licheniformis prevents and reduces anxiety-like and depression-like behaviours

Feng, Siyuan; Chen, Meng; Liu, Yiyuan; Yi, Yue; Liang, Axin; Zhang, Yingyu; Hao, Zikai

doi:10.1007/s00253-023-12580-7

Cited by 12 publications

(5 citation statements)

References 60 publications

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“…Our findings align with certain aspects of prior research showing that these microbiota are associated with anxiety and other psychiatric disorders; for instance, the lower abundance of Parabacteroides distasonis was examined in those people with mild cognitive impairment recently and animals with chronic restraint stress‐induced depression (Feng et al., 2023; McLeod et al., 2023; Yang et al., 2021). And other fecal microbiota analysis revealed that maternal immune activation offspring with increases the risk of autism spectrum disorder had a significant higher abundance of Alistipes , Fusobacterium , and Ruminococcus and a lower abundance of Coprococcus , Erysipelotrichaies , and Actinobacteria than control offspring, which is consistent with that of humans with ASD (De Angelis et al., 2013; Hsiao et al., 2013; Krajmalnik‐Brown et al., 2015; Lee et al., 2021; Liu et al., 2019; Wang et al., 2013).…”

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 90%

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The gut microbiome modulates the susceptibility to traumatic stress in a sex‐dependent manner

Shen,

Chang,

et al. 2024

J of Neuroscience Research

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Post‐traumatic stress disorder (PTSD), a psychological condition triggered by exposure to extreme or chronic stressful events, exhibits a sex bias in incidence and clinical manifestations. Emerging research implicates the gut microbiome in the pathogenesis of PTSD and its roles in stress susceptibility. However, it is unclear whether differential gut microbiota contribute to PTSD susceptibility in male and female rats. Here, we utilized the single prolonged stress animal model and employed unsupervised machine learning to classify stressed animals into stress‐susceptible subgroups and stress‐resilient subgroups. Subsequently, using 16S V3‐V4 rDNA sequencing, we investigated the differential gut microbiota alterations between susceptible and resilient individuals in male and female rats. Our findings revealed distinct changes in gut microbiota composition between the sexes at different taxonomic levels. Furthermore, the abundance of Parabacteroides was lower in rats that underwent SPS modeling compared to the control group. In addition, the abundance of Tenericutes in the stress‐susceptible subgroup was higher than that in the control group and stress‐resilient subgroup, suggesting that Tenericutes may be able to characterize stress susceptibility. What is particularly interesting here is that Cyanobacteria may be particularly associated with anti‐anxiety effects in male rats. This study underscores sex‐specific variations in gut microbiota composition in response to stress and sex differences should be taken into account when using macrobiotics for neuropsychiatric treatment, highlighting potential targets for PTSD therapeutic interventions.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 90%

The gut microbiome modulates the susceptibility to traumatic stress in a sex‐dependent manner

Shen,

Chang,

et al. 2024

J of Neuroscience Research

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“…On one hand, trauma can disrupt the balance of the gut microbiota, potentially leading to the development of neuropsychiatric sequelae, which is consistent with published literature ( 6 , 8 ).On the other hand, there is an increase in certain beneficial bacteria, which helps the host adapt to these changes. For instance, higher levels of Verrucomicrobia and Lentisphaerae are associated with better sleep quality ( 47 ),which is known to influence the onset and severity of depression ( 48 ).Several studies have shown that a sustainable abundance of Akkermansia and Butyricimonas can alleviate depressive symptoms ( 46 , 49 ).Bacillus licheniformis and Lactobacillales, recognized as probiotics, have been applied in pre-clinical trials to moderate anxiety and depression ( 50 , 51 ).These bacteria can alleviate stress and reduce symptoms of MDD in the host by producing or influencing certain metabolites, such as SCFAs. SCFAs are recognized for their broad range of health benefits in mammals, including anti-inflammatory activity and potential neuroprotection ( 41 ).Such SCFAs can cross the blood-brain barrier and modulate neuroinflammation, neurotransmission, and brain cell integrity ( 52 , 53 ).…”

Section: Discussionmentioning

confidence: 99%

The gut microbiota and post-traumatic major depression disorder: insights from bidirectional two-sample Mendelian randomization

Liu,

Wang,

Zhang

et al. 2024

Front. Psychiatry

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BackgroundExposure to trauma is often associated with an increased incidence of Major Depressive Disorder (MDD), yet the mechanisms underlying MDD development post-trauma remain elusive. The microbiota-gut-brain axis has been implicated in neuropsychiatric disorders, suggesting its potential role in post-traumatic MDD (PTMDD) development. Our study aimed to assess the significance of the gut microbiome-brain interaction in PTMDD.MethodsWe conducted a bidirectional two-sample Mendelian Randomization (MR) analysis to investigate the causal relationship between the gut microbiota and both PTMDD and trauma exposure in MDD. Genome-wide association study (GWAS) summary datasets for PTMDD and trauma exposure in MDD, both derived from the UK Biobank. The PTMDD dataset included 24,090 individuals (13,393 cases and 10,701 controls), while the dataset for trauma exposure in MDD comprised 22,880 participants (13,393 cases and 9,487 controls). Additionally, gut microbiota data from the MiBioGen consortium included 14,306 European individuals across 18 diverse cohorts.ResultsOur research identified a significant negative association between the phylum Verrucomicrobia (odds ratio (OR) [95% confidence interval (CI)] =0.799 [0.684–0.933], P=0.005) and the risk of developing PTMDD, suggesting a protective role for Verrucomicrobia against PTMDD. Conversely, our findings indicate no causal effects of the gut microbiota on trauma exposure in MDD. However, reverse analysis revealed that both PTMDD and MDD influence certain bacterial traits, affecting 5 and 9 bacterial traits, respectively. Moreover, Verrucomicrobia (OR [95% CI] = 1.166 [1.051 - 1.294], P=0.004) was found to be positively impacted by trauma exposure in MDD.ConclusionOur findings provide a cause-and-effect relationship between the gut microbiota and PTMDD, contributing to our understanding of the microbiota-gut-brain axis and its role in neuropsychiatric disorder development after trauma. This information provides an opportunity for new treatment and prevention methods which are aimed at the gut-brain interaction.

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“…Alterations in neuroendocrine homeostasis, i.e., CORT and catecholamines (such as EP and NE) levels, have been identified as the final common pathways in controlling animal behavior and pathophysiological status [ 151 ]. Animals raised in a germ-free (GF) environment expressing an exaggerated HPA response to psychological stressors could be normalized with certain bacterial probiotic species, such as Bifidobacterium infantis [ 152 , 153 ] and Bacillus licheniformis [ 154 ]. The animals treated with probiotics had a blunted HPA response [ 155 ].…”

Section: Cecal Microbiota Transplantation Social Stress and Injurious...mentioning

confidence: 99%

The Impact of Early-Life Cecal Microbiota Transplantation on Social Stress and Injurious Behaviors in Egg-Laying Chickens

Fu,

Hu,

Zhang

et al. 2024

Microorganisms

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Injurious behaviors (i.e., aggressive pecking, feather pecking, and cannibalism) in laying hens are a critical issue facing the egg industry due to increased social stress and related health and welfare issues as well as economic losses. In humans, stress-induced dysbiosis increases gut permeability, releasing various neuroactive factors, causing neuroinflammation and related neuropsychiatric disorders via the microbiota–gut–brain axis, and consequently increasing the frequency and intensity of aggression and violent behaviors. Restoration of the imbalanced gut microbial composition has become a novel treatment strategy for mental illnesses, such as depression, anxiety, bipolar disorder, schizophrenia, impulsivity, and compulsivity. A similar function of modulating gut microbial composition following stress challenge may be present in egg-laying chickens. The avian cecum, as a multi-purpose organ, has the greatest bacterial biodiversity (bacterial diversity, richness, and species composition) along the gastrointestinal tract, with vitally important functions in maintaining physiological and behavioral homeostasis, especially during the periods of stress. To identify the effects of the gut microbiome on injurious behaviors in egg-laying chickens, we have designed and tested the effects of transferring cecal contents from two divergently selected inbred chicken lines on social stress and stress-related injurious behaviors in recipient chicks of a commercial layer strain. This article reports the outcomes from a multi-year study on the modification of gut microbiota composition to reduce injurious behaviors in egg-laying chickens. An important discovery of this corpus of experiments is that injurious behaviors in chickens can be reduced or inhibited through modifying the gut microbiota composition and brain serotonergic activities via the gut–brain axis, without donor-recipient genetic effects.

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Bacillus licheniformis prevents and reduces anxiety-like and depression-like behaviours

Cited by 12 publications

References 60 publications

The gut microbiome modulates the susceptibility to traumatic stress in a sex‐dependent manner

The gut microbiome modulates the susceptibility to traumatic stress in a sex‐dependent manner

The gut microbiota and post-traumatic major depression disorder: insights from bidirectional two-sample Mendelian randomization

The Impact of Early-Life Cecal Microbiota Transplantation on Social Stress and Injurious Behaviors in Egg-Laying Chickens

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