Bacillus coagulans (Weizmannia coagulans) XY2 attenuates Cu-induced oxidative stress via DAF-16/FoxO and SKN-1/Nrf2 pathways and gut microbiota regulation

Gao, Yufang; Yu, Ting; Wu, Yuting; Huang, Xuedi; Teng, Jialuo; Zhao, Nan; Zheng, Xiaodong; Yan, Fujie

doi:10.1016/j.jhazmat.2023.131741

Cited by 14 publications

(11 citation statements)

References 56 publications

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“…In mice, copper disrupts the ecological balance and diversity of the gut microbiota, increasing Enterobacteriaceae while reducing the abundance of Bacteroidaceae , Ruminococcaceae , and Lachnospiraceae . However, Bacillus subtilis reverses copper toxicity by increasing taurine and L-glutamate levels while decreasing phosphatidylcholine and phosphatidylethanolamine, moving toward alleviating metabolic disruption ( Gao et al, 2023 ). Olive oil supplementation prevents type 1 diabetes in NOD mice by modulating the gut microbiota and serum metabolites ( Wang et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

Relationships among gut microbiota, plasma metabolites, and juvenile idiopathic arthritis: a mediation Mendelian randomization study

Gao,

Wang,

Wang

et al. 2024

Front. Microbiol.

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ObjectiveThe objective of this study is to investigate the causal relationship between gut microbiota and juvenile idiopathic arthritis, and to identify and quantify the potential role of plasma metabolites as mediators.MethodsUsing summary-level data from genome-wide association studies, a two-sample Mendelian randomization was conducted involving 131 gut microbiota genus, 1,400 plasma metabolites, and juvenile idiopathic arthritis. Additionally, a two-step approach was employed to quantify the proportion of the effect of gut microbiota on juvenile idiopathic arthritis mediated by plasma metabolites. Effect estimation primarily utilized Inverse Variance Weighting, with further validation using Bayesian weighted Mendelian randomization.ResultsIn our MR analysis, a positive correlation was observed between Rikenellaceae and the risk of juvenile idiopathic arthritis, while Dorea showed a negative correlation with juvenile idiopathic arthritis risk. Mediation analysis indicated that Furaneol sulfate levels acted as a mediator between Dorea and juvenile idiopathic arthritis, with an indirect effect proportion of 19.94, 95% CI [8.86–31.03%].ConclusionOur study confirms a causal relationship between specific microbial genus and juvenile idiopathic arthritis, and computes the proportion of the effect mediated by plasma metabolites, offering novel insights for clinical interventions in juvenile idiopathic arthritis.

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Section: Discussionmentioning

confidence: 99%

Relationships among gut microbiota, plasma metabolites, and juvenile idiopathic arthritis: a mediation Mendelian randomization study

Gao,

Wang,

Wang

et al. 2024

Front. Microbiol.

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“…Regarding the modified species, Ruminococcus torques was reported to be associated with the alleviation of inflammation through regulating bile acid compositions ( Zhang M et al, 2023 ). At the genus level, both Intestinimonas and Ruminococcus2 are butyric acid-producing bacteria, deemed potential probiotics for alleviating and treating inflammatory diseases due to their capacity to regulate T regulatory cells and inhibit Histone Deacetylase (HDAC) ( Gao et al, 2023 ). Additionally, it has been revealed that Dorea , a commensal bacterium, functions as immune sentinels within tissues ( Zhang et al, 2023b ).…”

Section: Discussionmentioning

confidence: 99%

Dissecting the association between gut microbiota and hypertrophic scarring: a bidirectional Mendelian randomization study

Xue,

Zhang,

et al. 2024

Front. Microbiol.

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Hypertrophic scars affect a significant number of individuals annually, giving rise to both cosmetic concerns and functional impairments. Prior research has established that an imbalance in the composition of gut microbes, termed microbial dysbiosis, can initiate the progression of various diseases through the intricate interplay between gut microbiota and the host. However, the precise nature of the causal link between gut microbiota and hypertrophic scarring remains uncertain. In this study, after compiling summary data from genome-wide association studies (GWAS) involving 418 instances of gut microbiota and hypertrophic scarring, we conducted a bidirectional Mendelian randomization (MR) to investigate the potential existence of a causal relationship between gut microbiota and the development of hypertrophic scar and to discern the directionality of causation. By utilizing MR analysis, we identified seven causal associations between gut microbiome and hypertrophic scarring, involving one positive and six negative causal directions. Among them, Intestinimonas, Ruminococcus2, Barnesiella, Dorea, Desulfovibrio piger, and Ruminococcus torques act as protective factors against hypertrophic scarring, while Eubacterium rectale suggests a potential role as a risk factor for hypertrophic scars. Additionally, sensitivity analyses of these results revealed no indications of heterogeneity or pleiotropy. The findings of our MR study suggest a potential causative link between gut microbiota and hypertrophic scarring, opening up new ways for future mechanistic research and the exploration of nanobiotechnology therapies for skin disorders.

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“…Transporters for heme, hemin, and iron, which are linked to the vitamin B12 transport system, are strongly increased in the newborn metagenome [59]. B. coagulans administration has been shown to increase the levels of L-glutamate [60], which starts the tetrapyrrole biosynthesis pathway in bacteria (http://vm-trypanocyc.toulouse.inra.fr/META/NEW-IMAGE?type=PATHWAY& object=PWY-5918, accessed on 22 July 2023). It is thus tempting to speculate that increased amounts of protoheme synthesized by B. coagulans, or by other enteric bacteria enriched by the treatment, could be incorporated into the hepatic heme pool through portal circulation, contributing to palliating the deficiency in endogenous heme synthesis due to PBGD impairment.…”

Section: Discussionmentioning

confidence: 99%

Nutritional Interventions with Bacillus coagulans Improved Glucose Metabolism and Hyperinsulinemia in Mice with Acute Intermittent Porphyria

Longo

Jericó

Córdoba

et al. 2023

IJMS

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Acute intermittent porphyria (AIP) is a metabolic disorder caused by mutations in the porphobilinogen deaminase (PBGD) gene, encoding the third enzyme of the heme synthesis pathway. Although AIP is characterized by low clinical penetrance (~1% of PBGD mutation carriers), patients with clinically stable disease report chronic symptoms and frequently show insulin resistance. This study aimed to evaluate the beneficial impact of nutritional interventions on correct carbohydrate dysfunctions in a mouse model of AIP that reproduces insulin resistance and altered glucose metabolism. The addition of spores of Bacillus coagulans in drinking water for 12 weeks modified the gut microbiome composition in AIP mice, ameliorated glucose tolerance and hyperinsulinemia, and stimulated fat disposal in adipose tissue. Lipid breakdown may be mediated by muscles burning energy and heat dissipation by brown adipose tissue, resulting in a loss of fatty tissue and improved lean/fat tissue ratio. Probiotic supplementation also improved muscle glucose uptake, as measured using Positron Emission Tomography (PET) analysis. In conclusion, these data provide a proof of concept that probiotics, as a dietary intervention in AIP, induce relevant changes in intestinal bacteria composition and improve glucose uptake and muscular energy utilization. Probiotics may offer a safe, efficient, and cost-effective option to manage people with insulin resistance associated with AIP.

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Bacillus coagulans (Weizmannia coagulans) XY2 attenuates Cu-induced oxidative stress via DAF-16/FoxO and SKN-1/Nrf2 pathways and gut microbiota regulation

Cited by 14 publications

References 56 publications

Relationships among gut microbiota, plasma metabolites, and juvenile idiopathic arthritis: a mediation Mendelian randomization study

Relationships among gut microbiota, plasma metabolites, and juvenile idiopathic arthritis: a mediation Mendelian randomization study

Dissecting the association between gut microbiota and hypertrophic scarring: a bidirectional Mendelian randomization study

Nutritional Interventions with Bacillus coagulans Improved Glucose Metabolism and Hyperinsulinemia in Mice with Acute Intermittent Porphyria

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