Bacillus cereus septicemia in a patient with acute lymphoblastic leukemia: A case report and review of the literature

Abstract

Bacillus cereus is an aerobic Gram-positive, spore-forming, rod-shaped bacterium that is responsible for foodborne illnesses. We report on a 15-year-old girl with B-cell acute lymphoblastic leukemia, who fell into a somnolent state after presenting with a 12-hour history of fever, muscle soreness, myalgia in both calves, sore throat, and vomiting. Fulminant septicemic syndrome caused by B. cereus was finally identified. The aim of this work is the introduction of B. cereus as a differential diagnosis of sepsis in patients with acute leukemia in induction chemotherapy, to prevent delayed treatment.

Simultaneous Monitoring of Disease and Microbe Dynamics Through Plasma DNA Sequencing in Pediatric Patients with Acute Lymphoblastic Leukemia

“…Conversely, Cutibacterium were detected in most ALL samples but none of the healthy controls (Supplemental Figure 4), which may represent the ability of the commensal skin bacteria to invade the human host. Importantly, Bacillus species, a known cause of mortality of pediatric ALL patients 45 , were detected in a subset of patients. For fungal DNA, Malassezia species were detected in 60% of healthy controls and 13/17 (82%) of diagnostic ALL samples, but none of the AML samples (Supplementary Figure 5).…”

Bacillus cereus Catheter-Related Infection in Acute Lymphoblastic Leukemia (ALL) Patient: A Case Report and Review of Literature

“…cereus septicaemia is a relatively rare event which accounts for about 2% of all cases of bacteremia or fungemia [5]. The few reports of septicemia due to B. cereus deal with patients with severe neutropenia who were receiving chemotherapy for hematologic malignancies [2,[6][7][8][9][10][11][12][13][14][15]. In these patients the clinical course was generally fulminant and death was rapid.…”

Tumor rabdoide teratoide atípico del sistema nervioso central con INI1 positivo : presentación de un caso pediátrico.

“…El tumor rabdoide teratoide atípico (TRTA) del sistema nervioso central (SNC) fue descrito por primera vez por Rorke et al en 1987 1 . Se trata de un tumor maligno embrionario raro del sistema nervioso central, con un pico de incidencia entre el nacimiento y los 3 años de edad.…”

“…Se trata de un tumor maligno embrionario raro del sistema nervioso central, con un pico de incidencia entre el nacimiento y los 3 años de edad. Constituye aproximadamente el 1 a 2 % de los tumores pediátricos del SNC y en el 50 % de los casos se localiza en la fosa posterior 1,2,3 . El TRTA tiene una mediana de sobrevida de 10 a 14 meses 4,5 .…”

“…El diagnóstico del TRTA se basa en la identificación morfológica e inmunohistoquímica de células rabdoides teratoides, las cuales muestran inmunoreactividad para un amplio rango de marcadores epiteliales, mesenquimales, gliales y neuronales 1,6,7 .…”