Bacillus cereus infections in Traumatology–Orthopaedics Department: retrospective investigation and improvement of healthcare practices

Dubouix, Anne; Bonnet, É.; Alvarez, M.; Bensafi, H.; Archambaud, M.; Chaminade, B.; Chabanon, G.; Marty, N.

doi:10.1016/j.jinf.2004.05.012

Cited by 34 publications

(24 citation statements)

References 17 publications

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“…Depending upon the environment in which the trauma takes place, e.g., fresh or salt water or soil, recognized microbial species such as Pseudomonas aeruginosa or Aeromonas or Vibrio species predominate (107), whereas Bacillus species isolated from trauma-induced wounds, whether water related or not, are usually regarded as contaminants and basically ignored until a more dramatic complication such as, for example, sepsis or necrotizing fasciitis occurs and is attributed to the bacillary species. In recent years, however, the recognition of B. cereus as a major pathogen infecting individuals who sustain traumatic injuries is being well documented (2,22,42,81,107). Because of the wide environmental distribution of B. cereus spores, especially in soil, they can easily disseminate through dust, water, and food.…”

Section: Vol 23 2010mentioning

confidence: 99%

“…Wound contamination with B. cereus can take place at the time of initial trauma due to the ubiquitous presence of B. cereus spores in the environment. Alternatively, the capacity of B. cereus spores to persist in plasterimpregnated gauze (112), incontinence pads, and hospital linen (11,12) as well as in many antiseptics such as chlorhexidine, povodone iodine, and alcohol (42,69) facilitates this bacterium's capacity to function as a secondary nosocomial invader of sites of traumatic injury (Table 1).…”

Section: Vol 23 2010mentioning

confidence: 99%

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Bacillus cereus , a Volatile Human Pathogen

2010

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SUMMARY Bacillus cereus is a Gram-positive aerobic or facultatively anaerobic, motile, spore-forming, rod-shaped bacterium that is widely distributed environmentally. While B. cereus is associated mainly with food poisoning, it is being increasingly reported to be a cause of serious and potentially fatal non-gastrointestinal-tract infections. The pathogenicity of B. cereus, whether intestinal or nonintestinal, is intimately associated with the production of tissue-destructive exoenzymes. Among these secreted toxins are four hemolysins, three distinct phospholipases, an emesis-inducing toxin, and proteases. The major hurdle in evaluating B. cereus when isolated from a clinical specimen is overcoming its stigma as an insignificant contaminant. Outside its notoriety in association with food poisoning and severe eye infections, this bacterium has been incriminated in a multitude of other clinical conditions such as anthrax-like progressive pneumonia, fulminant sepsis, and devastating central nervous system infections, particularly in immunosuppressed individuals, intravenous drug abusers, and neonates. Its role in nosocomial acquired bacteremia and wound infections in postsurgical patients has also been well defined, especially when intravascular devices such as catheters are inserted. Primary cutaneous infections mimicking clostridial gas gangrene induced subsequent to trauma have also been well documented. B. cereus produces a potent β-lactamase conferring marked resistance to β-lactam antibiotics. Antimicrobials noted to be effective in the empirical management of a B. cereus infection while awaiting antimicrobial susceptibility results for the isolate include ciprofloxacin and vancomycin.

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Section: Vol 23 2010mentioning

confidence: 99%

Section: Vol 23 2010mentioning

confidence: 99%

Bacillus cereus , a Volatile Human Pathogen

2010

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“…A-051, 2004). We investigated the activities of daptomycin against Bacillus cereus and other Bacillus species since these organisms are increasingly being implicated in gastrointestinal disease and various other serious infections, such as bacteremia (2,4,13,14,16), meningitis (5,13), pneumonia (12), endophthalmitis (11,20), periodontitis (15), and other infections (1,9,10,17,18,21), especially in immunocompromised patients.…”

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confidence: 99%

In Vitro Activities of Daptomycin, Ciprofloxacin, and Other Antimicrobial Agents against the Cells and Spores of Clinical Isolates of Bacillus Species

Citron

Appleman

2006

J Clin Microbiol

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“…20 Dubouix et al reported distinct fingerprinting patterns in all 30 Bacillus cereus strains isolated from infections in a traumatology-orthopedics department. 21 As previously reported, recognizing and tracking the source of such pseudo-outbreaks is a difficult task. 8,11 Loeb et al reported pseudobacteremia following hospital construction.…”

Section: Discussionmentioning

confidence: 97%

Undetected Bacillus pseudo-outbreak after renovation work in a teaching hospital

Ohsaki

Koyano

Tachibana

et al. 2007

Journal of Infection

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word count: 199 words Text body word count:2491 words -1- We found more Bacillus cereus isolates from blood samples in 2004 compare to the preceding years. Swab samples were collected in the particular ward from the surface of a working desk, filter unit of the air-conditioners, entrance of air inlet ducts, exit of the air outlet ducts and three-way valves of the particular ward under the consideration of iatrogenic contamination. Towels and gowns used in the ward were examined. Undetected Bacillus Pseudo-Outbreak after Renovation WorkDens dust was noted in the filter of the air-conditioner and inlets/outlets of the air-ventilation system of the ward. Bacillus cereus was isolated from the dust, and from cleaned towels and gowns. PFGE fingerprinting differed among four patients' sample. We considered the present case as an undetected Bacillus cereus pseudo-outbreak that lasted for about one year after the renovation work of the hospital.We also considered that filters of the HVAC-system and towels and gowns were probable sources of the outbreak.

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Bacillus cereus infections in Traumatology–Orthopaedics Department: retrospective investigation and improvement of healthcare practices

Cited by 34 publications

References 17 publications

Bacillus cereus , a Volatile Human Pathogen

Bacillus cereus , a Volatile Human Pathogen

In Vitro Activities of Daptomycin, Ciprofloxacin, and Other Antimicrobial Agents against the Cells and Spores of Clinical Isolates of Bacillus Species

Undetected Bacillus pseudo-outbreak after renovation work in a teaching hospital

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