Bacillus cereus, an unusual cause of fulminant liver failure: diagnosis may prevent liver transplantation

Saleh, Mohamed; Nakib, Malik Al; Doloy, Alexandra; Jacqmin, Sébastien; Ghiglione, S.; Verroust, Nicolas; Poyart, Claire; Ozier, Yves

doi:10.1099/jmm.0.038547-0

Cited by 17 publications

(14 citation statements)

References 12 publications

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“…Contradictory to the publication of Saleh et al. , we conclude that under certain conditions, the correct diagnosis cannot prevent liver transplantation because there is no time to await results. In contrast to the fatal courses, all of the four surviving patients (2–15 yr old) reported in the literature had life‐threatening illness but stabilized quickly under intensive care therapy and had recovered no later than after eight days.…”

Section: Case Reportmentioning

confidence: 78%

“…In the literature, nine severe cases of liver failure and/or rhabdomyolysis due to food poisoning with B. cereus are reported with fatal outcome in five of these patients . Four of five patients died within 7–13 h after eating a contaminated meal, and one patient died after three days while he was evaluated and waiting for liver transplantation.…”

Section: Case Reportmentioning

confidence: 99%

“…In general, food poisoning with B. cereus is mild and self‐limiting. However, due to cereulide intoxication, nine severe cases with rhabdomyolysis and/or liver failure, five of them lethal, are reported in the literature . Liver transplantation is an established treatment for liver failure due to intoxications with different substances (e.g., paracetamol, amanitin) .…”

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confidence: 99%

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Lifesaving liver transplantation for multi‐organ failure caused by Bacillus cereus food poisoning

Tschiedel

Rath

Steinmann

et al. 2014

Pediatric Transplantation

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Bacillus cereus is a spore-forming, gram-positive bacterium that causes food poisoning presenting with either emesis or diarrhea. Diarrhea is caused by proteinaceous enterotoxin complexes, mainly hemolysin BL, non-hemolytic enterotoxin (NHE), and cytotoxin K. In contrast, emesis is caused by the ingestion of the depsipeptide toxin cereulide, which is produced in B. cereus contaminated food, particularly in pasta or rice. In general, the illness is mild and self-limiting. However, due to cereulide intoxication, nine severe cases with rhabdomyolysis and/or liver failure, five of them lethal, are reported in literature. Here we report the first case of life-threatening liver failure and severe rhabdomyolysis in this context that could not be survived without emergency hepatectomy and consecutive liver transplantation.

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Section: Case Reportmentioning

confidence: 78%

Section: Case Reportmentioning

confidence: 99%

mentioning

confidence: 99%

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Lifesaving liver transplantation for multi‐organ failure caused by Bacillus cereus food poisoning

Tschiedel

Rath

Steinmann

et al. 2014

Pediatric Transplantation

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“…Bacillus cereus food poisoning has frequently been linked to heat treated foods which support growth of this bacterium, particularly in case of storage at inadequate temperatures (EFSA, 2005 (Dierick et al, 2005), pasta (Saleh et al, 2012), spaghetti meal (Naranjo et al, 2011), rice pudding (Kamga Wambo et al, 2011), vegetable purée (de Buyser et al, 2008, and with fried rice in Japan (Ichikawa et al, 2010). Rare foodborne episodes have been caused by other Bacillus species, Bacillus subtilis (Kramer and Gilbert, 1989), Bacillus licheniformis (Kramer and Gilbert, 1989), Bacillus pumilus (From et al, 2007).…”

Section: Bacillus Cereus and Other Bacillus Speciesmentioning

confidence: 99%

“…Other FoNAO have caused Bacillus cereus foodborne illnesses and these have included: home-grown sprouted seeds, vegetarian meat substitute, vegetable purées, potato salads, orange juice from concentrate, onion powder(EFSA, 2005). Since 2007, Bacillus cereus foodborne outbreaks within the EU have been implicated with breakfast cereals(Duc et al, 2005), pasta salad(Dierick et al, 2005), pasta(Saleh et al, 2012), spaghetti meal(Naranjo et al, 2011), rice pudding(Kamga Wambo et al, 2011), vegetable purée (de Buyser et al, 2008, and…”

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confidence: 99%

Scientific Opinion on the risk posed by pathogens in food of non-animal origin. Part 1 (outbreak data analysis and risk ranking of food/pathogen combinations)

Publication¹

2013

EFSA Journal

169

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European Food Safety Authority (EFSA), Parma, Italy ABSTRACTFood of non-animal origin (FoNAO) is consumed in a variety of forms, and a major component of almost all meals. These food types have the potential to be associated with large outbreaks as seen in 2011 associated with VTEC O104. A comparison of the incidence of human cases linked to consumption of FoNAO and of food of animal origin (FoAO) was carried out to provide an indication of the proportionality between these two groups of foods. It was concluded that outbreak data reported as part of EU Zoonoses Monitoring is currently the only option for EU-wide comparative estimates. Using this data from 2007 to 2011, FoNAO were associated with 10% of the outbreaks, 26% of the cases, 35% of the hospitalisations and 46% of the deaths. If the data from the 2011VTEC O104 outbreak is excluded, FoNAO was associated with 10% of the outbreaks, 18% of cases, but only 8% of the hospitalisations and 5% of the deaths. From 2008 to 2011 there was an increase in the numbers of reported outbreaks, cases, hospitalisations and deaths associated with food of non-animal origin. In order to identify and rank specific food/pathogen combinations most often linked to human cases originating from FoNAO in the EU, a model was developed using seven criteria: strength of associations between food and pathogen based on the foodborne outbreak data from EU Zoonoses Monitoring (2007-11), incidence of illness, burden of disease, dose-response relationship, consumption, prevalence of contamination and pathogen growth potential during shelf life. Shortcomings in the approach using outbreak data were discussed. The top ranking food/pathogen combination was Salmonella spp. and leafy greens eaten raw followed by (in equal rank) Salmonella spp. and bulb and stem vegetables, Salmonella spp. and tomatoes, Salmonella spp. and melons, and pathogenic Escherichia coli and fresh pods, legumes or grain.© European Food Safety Authority, 2013 KEY WORDSFood of non-animal origin, foodborne pathogens, foodborne outbreaks, food/pathogen combination, risk ranking SUMMARYThe European Commission asked EFSA"s BIOHAZ Panel to prepare a scientific Opinion on the public health risk posed by pathogens that may contaminate food of non-animal origin (FoNAO). In particular, this opinion addresses the first two terms of reference for the mandate, namely: (i) to compare the incidence of foodborne human cases linked to FoNAO and foodborne cases linked to food of animal origin (FoAO), and (ii) to identify and rank specific food/pathogen combinations most often linked to foodborne human cases originating from FoNAO in the EU.For the comparison of the incidence of foodborne human cases linked to FoNAO and foodborne cases linked to FoAO, the BIOHAZ Panel concluded that: the analysis of the outbreak data reported as part of EU Zoonoses Monitoring allows attribution of human cases to food of non-animal origin or food of animal origin, and is currently the only option for obtaining a EU-wide comparative estimate of the proportion ...

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Hepatotoxicity of Herbals and Dietary Supplements

Seeff¹,

Stickel²,

Navarro³

2013

Drug-Induced Liver Disease

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Bacillus cereus, an unusual cause of fulminant liver failure: diagnosis may prevent liver transplantation

Cited by 17 publications

References 12 publications

Lifesaving liver transplantation for multi‐organ failure caused by Bacillus cereus food poisoning

Lifesaving liver transplantation for multi‐organ failure caused by Bacillus cereus food poisoning

Scientific Opinion on the risk posed by pathogens in food of non-animal origin. Part 1 (outbreak data analysis and risk ranking of food/pathogen combinations)

Hepatotoxicity of Herbals and Dietary Supplements

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