Bacillomycin D and its combination with amphotericin B: promising antifungal compounds with powerful antibiofilm activity and wound-healing potency

Tabbene, Olfa; Azaiez, S.; Grazia, Antonio Di; Karkouch, Ines; Slimene, Imen Ben; Elkahoui, Salem; Alfeddy, M. N.; Casciaro, Bruno; Luca, Vincenzo; Limam, Férid; Mangoni, Maria Luisa

doi:10.1111/jam.13030

Cited by 28 publications

(18 citation statements)

References 50 publications

(110 reference statements)

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“…Further, a single combined dose of oligo-acyl-lysyls (OAKs) with rifampin also imparts increased survival chances from 10–20% to 60% against Klebsiella infected mice [61]. In addition, the combination of a lipopeptide bacillomycin D with antifungal amphotericin B leads to excellent antibiofilm and wound-healing properties against Candida albicans [62]. Inexpensive compounds (e.g., ZnCl 2 , NaF, or EDTA) can also be used as synergistic elements to improve peptide activity [63].…”

Section: Application Strategies Of Antimicrobial Peptidesmentioning

confidence: 99%

Host defense antimicrobial peptides as antibiotics: design and application strategies

Mishra

Reiling

Zarena

et al. 2017

Current Opinion in Chemical Biology

253

213

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This review deals with the design and application strategies of new antibiotics based on naturally occurring antimicrobial peptides (AMPs). The initial candidate can be designed based on three-dimensional structure or selected from a library of peptides from natural or laboratory sources followed by optimization via structure-activity relationship studies. There are also advanced application strategies such as induction of AMP expression from host cells by various factors (e.g., metals, amino acids, vitamin D and sunlight), the use of engineered probiotic bacteria to deliver peptides, the design of prodrug and peptide conjugates to improve specific targeting. In addition, combined uses of newly developed AMPs with existing antimicrobial agents may provide a practical avenue for effective management of antibiotic-resistant bacteria (superbugs, including biofilm). Finally, we highlight AMPs already in use or under clinical trials.

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Section: Application Strategies Of Antimicrobial Peptidesmentioning

confidence: 99%

Host defense antimicrobial peptides as antibiotics: design and application strategies

Mishra

Reiling

Zarena

et al. 2017

Current Opinion in Chemical Biology

253

213

View full text Add to dashboard Cite

show abstract

“…Recent studies have also demonstrated that peptides can be used in conjunction with antibiotics, antifungals, or other antimicrobial compounds, which leads to enhanced activity (i.e. synergistic effects) [16–18]. Lowering antibiotic concentrations helps to reduce expenses, toxic side effects, and the spread of antimicrobial resistance.…”

Section: Peptides Enhance the Activity Of Other Antimicrobial Agentsmentioning

confidence: 99%

“…The combination of the lipopeptide bacillomycin D and the antifungal drug amphotericin B was strongly synergistic against C. albicans biofilms [18]. Moreover, peptide AS10 was able to act synergistically with the antifungal drugs caspofungin and amphotericin B against C. albicans biofilms [16].…”

Section: Peptides Enhance the Activity Of Other Antimicrobial Agentsmentioning

confidence: 99%

Anti-biofilm peptides as a new weapon in antimicrobial warfare

Pletzer

Coleman

Hancock

2016

Current Opinion in Microbiology

141

104

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Microorganisms growing in a biofilm state are very resilient in the face of treatment by many antimicrobial agents. Biofilm infections are a significant problem in chronic and long-term infections, including those colonizing medical devices and implants. Anti-biofilm peptides represent a very promising approach to treat biofilm-related infections and have an extraordinary ability to interfere with various stages of the biofilm growth mode. Anti-biofilm peptides possess promising broad-spectrum activity in killing both Gram-positive and Gram-negative bacteria in biofilms, show strong synergy with conventional antibiotics, and act by targeting a universal stringent stress response. Understanding downstream processes at the molecular level will help to develop and design peptides with increased activity. Anti-biofilm peptides represent a novel, exciting approach to treating recalcitrant bacterial infections.

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“…Studies have found that a number of metabolites from microbial strains including lipopeptide, macrolide, surfactin (Santos et al 2018), fengycin (Fan et al 2017), iturin , bacillomycin D (Tabbene et al 2016), chitinase (Shehata et al 2018), and other active proteins (Li et al 2009) have antimicrobial activity. It is reported that the mainly antimicrobial substances produced by Bacillus are presented with different proteins and lipopeptides (Abriouel et al 2011).…”

Section: Discussionmentioning

confidence: 99%

A novel trehalosamine isolated from Bacillus amyloliquefaciens and its antibacterial activities

et al. 2020

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Bacillus amyloliquefaciens has been widely used as a probiotic in the field of biological control,and its antibacterial compounds plays an important role in the prevention and control of plant, livestock and poultry diseases. It has the advantages of green, safe and efficiency. This study aims to separate and purify active ingredient from Bacillus amyloliquefaciens GN59 and study its antibacterial activity. A novel compound was isolated from GN59 by column chromatography on silica gel and HPLC purification. The chemical structure was identified as α-dglucopyranosyl-(1 → 1′)-3′-amino-3′-deoxy-β-d-glucopyranoside (a,β-3-trehalosamine) on the basis of spectroscopic analysis. This is the first report about a,β-3-trehalosamine isolated from biological resources on an antibiotic activity against pathogenic bacterium. The 3′-neotrehalosamine displayed antibacterial activity across a broad spectrum of microorganisms, including different gram-positive and gram-negative bacteria, with minimal inhibitory concentration (MIC) values ranging from 0.5 to 0.7 mg/mL. The results indicated that the 3′-neotrehalosamine from GN59 might be a potential candidate for bactericide.

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Bacillomycin D and its combination with amphotericin B: promising antifungal compounds with powerful antibiofilm activity and wound-healing potency

Abstract: Application of the lipopeptide bacillomycin D and the antifungal drug amphotericin B in medical devices may offer a promising alternative for topical treatment of Candida-associated infections in the setting of a wound.

Cited by 28 publications

References 50 publications

Host defense antimicrobial peptides as antibiotics: design and application strategies

Host defense antimicrobial peptides as antibiotics: design and application strategies

Anti-biofilm peptides as a new weapon in antimicrobial warfare

A novel trehalosamine isolated from Bacillus amyloliquefaciens and its antibacterial activities

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