Bach2 Deficiency Promotes Intestinal Epithelial Regeneration by Accelerating DNA Repair in Intestinal Stem Cells

Li, Yuanchuang; Rao, Xinxin; Tang, Peiyuan; Chen, Shengzhi; Guo, Qiang; Fu, Guoxiang; Pan, Mengxue; Liang, Li‐Ping; Yao, Ye; Gao, Xiaojian; Zhou, Yi; Zhang, Zhen; Xu, Xiang; Hu, Wenhuo; Gao, Jianjun; Hua, Guoqiang

doi:10.1016/j.stemcr.2020.12.005

Cited by 7 publications

(2 citation statements)

References 26 publications

(27 reference statements)

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“…Limbal stem cell deficiency, triggered by surgical trauma, significantly impacts the epithelial renewal capacity [ 74 ]. This deficiency leads to impaired epithelial regeneration and repair mechanisms, contributing to epithelial thinning, irregularity, and inflammatory responses [ 75 ]. Basement membrane disruptions further exacerbate these effects, compromising the structural integrity of the corneal epithelium [ 76 ].…”

Section: Reviewmentioning

confidence: 99%

Post-refractive Surgery Dry Eye: A Systematic Review Exploring Pathophysiology, Risk Factors, and Novel Management Strategies

Dossari

2024

Cureus

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Dry eye disease frequently manifests following corneal refractive procedures, significantly impacting patients' quality of life. This review systematically synthesizes current evidence on the pathophysiological mechanisms, risk factors, and therapeutic interventions for post-refractive surgery dry eye. Following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines, a systematic review of literature published until August 2023 was conducted, focusing on post-refractive surgery dry eye. Eighteen relevant studies were identified through screening and eligibility assessment. A qualitative synthesis of outcomes was performed using narrative and thematic analysis methods. Surgically induced neurotrophic deficiency, stemming from nerve transection, triggers a cascade of events including apoptosis, inflammation, and lacrimal dysfunction, ultimately leading to tear film instability. Risk factors such as female gender, thyroid eye disease, meibomian gland dysfunction, higher ablation depths, and the use of LASIK over surface ablation exacerbate the condition. While conventional treatments like artificial tears provide temporary relief, emerging interventions such as nerve growth factors, matrix metalloproteinase inhibitors, serum eye drops, and specialized contact lenses show promise in promoting nerve regeneration and epithelial healing. Strategies such as customized ablation profiles, smaller optical zones, and nervesparing techniques like small incision lenticule extraction demonstrate potential advantages. A multifaceted therapeutic approach targeting neuroprotection, anti-inflammatory mechanisms, and tear film stabilization is imperative for effectively managing post-refractive surgery dry eye. Future research should focus on evaluating prognostic biomarkers, exploring precision medicine approaches, and investigating neuroprotective adjuvants to further enhance treatment outcomes.

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Section: Reviewmentioning

confidence: 99%

Post-refractive Surgery Dry Eye: A Systematic Review Exploring Pathophysiology, Risk Factors, and Novel Management Strategies

Dossari

2024

Cureus

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“…These findings reveal that BACH1 deficiency alleviates intestinal IR injury by increasing HO-1 expression. BACH2 deletion facilitates intestinal epithelial regeneration by promoting DNA repair of intestinal crypt cells in radiation-induced intestinal injury ( Li et al, 2021 ).…”

Section: Intestinal Diseasesmentioning

confidence: 99%

Pathophysiological role of BACH transcription factors in digestive system diseases

et al. 2023

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BTB and CNC homologous (BACH) proteins, including BACH1 and BACH2, are transcription factors that are widely expressed in human tissues. BACH proteins form heterodimers with small musculoaponeurotic fibrosarcoma (MAF) proteins to suppress the transcription of target genes. Furthermore, BACH1 promotes the transcription of target genes. BACH proteins regulate physiological processes, such as the differentiation of B cells and T cells, mitochondrial function, and heme homeostasis as well as pathogenesis related to inflammation, oxidative-stress damage caused by drugs, toxicants, or infections; autoimmunity disorders; and cancer angiogenesis, epithelial-mesenchymal transition, chemotherapy resistance, progression, and metabolism. In this review, we discuss the function of BACH proteins in the digestive system, including the liver, gallbladder, esophagus, stomach, small and large intestines, and pancreas. BACH proteins directly target genes or indirectly regulate downstream molecules to promote or inhibit biological phenomena such as inflammation, tumor angiogenesis, and epithelial-mesenchymal transition. BACH proteins are also regulated by proteins, miRNAs, LncRNAs, labile iron, and positive and negative feedback. Additionally, we summarize a list of regulators targeting these proteins. Our review provides a reference for future studies on targeted drugs in digestive diseases.

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Advances in the effect of gut-joint axis dysfunction on rheumatoid arthritis and the intervention of natural products

GUO,

LV,

YANG

et al. 2024

Chinese Journal of Analytical Chemistry

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Bach2 Deficiency Promotes Intestinal Epithelial Regeneration by Accelerating DNA Repair in Intestinal Stem Cells

Cited by 7 publications

References 26 publications

Post-refractive Surgery Dry Eye: A Systematic Review Exploring Pathophysiology, Risk Factors, and Novel Management Strategies

Post-refractive Surgery Dry Eye: A Systematic Review Exploring Pathophysiology, Risk Factors, and Novel Management Strategies

Pathophysiological role of BACH transcription factors in digestive system diseases

Advances in the effect of gut-joint axis dysfunction on rheumatoid arthritis and the intervention of natural products

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