Bach1: Function, Regulation, and Involvement in Disease

Zhang, Xinyue; Guo, Jr-Hung; Wei, Xiangxiang; Niu, Cong; Jia, Minghan; Li, Qinhan; Meng, Dan

doi:10.1155/2018/1347969

Cited by 119 publications

(106 citation statements)

References 74 publications

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“…BACH1, encoded on Hsa21, is a key element in the regulation of the antioxidant response in DS [6]. BACH1 is a transcription repressor that acts as a key regulator of the expression of genes involved in the cell stress response [36]. In DS, it is likely that upregulation of BACH1 protein levels could block the induction of antioxidant genes, therefore promoting increased OS in the cell [6].…”

Section: S100b (S100 Calcium-binding Protein B)mentioning

confidence: 99%

The BACH1/Nrf2 Axis in Brain in Down Syndrome and Transition to Alzheimer Disease-Like Neuropathology and Dementia

et al. 2020

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Down syndrome (DS) is the most common genetic cause of intellectual disability that is associated with an increased risk to develop early-onset Alzheimer-like dementia (AD). The brain neuropathological features include alteration of redox homeostasis, mitochondrial deficits, inflammation, accumulation of both amyloid beta-peptide oligomers and senile plaques, as well as aggregated hyperphosphorylated tau protein-containing neurofibrillary tangles, among others. It is worth mentioning that some of the triplicated genes encoded are likely to cause increased oxidative stress (OS) conditions that are also associated with reduced cellular responses. Published studies from our laboratories propose that increased oxidative damage occurs early in life in DS population and contributes to age-dependent neurodegeneration. This is the result of damaged, oxidized proteins that belong to degradative systems, antioxidant defense system, neuronal trafficking. and energy metabolism. This review focuses on a key element that regulates redox homeostasis, the transcription factor Nrf2, which is negatively regulated by BACH1, encoded on chromosome 21. The role of the Nrf2/BACH1 axis in DS is under investigation, and the effects of triplicated BACH1 on the transcriptional regulation of Nrf2 are still unknown. In this review, we discuss the physiological relevance of BACH1/Nrf2 signaling in the brain and how the dysfunction of this system affects the redox homeostasis in DS neurons and how this axis may contribute to the transition of DS into DS with AD neuropathology and dementia. Further, some of the evidence collected in AD regarding the potential contribution of BACH1 to neurodegeneration in DS are also discussed.

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Section: S100b (S100 Calcium-binding Protein B)mentioning

confidence: 99%

The BACH1/Nrf2 Axis in Brain in Down Syndrome and Transition to Alzheimer Disease-Like Neuropathology and Dementia

et al. 2020

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“…Remarkably, other relevant top hub genes were not DE, e.g. the BACH1 transcription factor, whose inhibition has been associated with an increased protection against oxidative stress [93], ETS1, which mediates FOXO1 acetylation and regulates gluconeogenesis in fastingfeeding cycles [94] or CREB1, an important cofactor for the peroxisome proliferator-activated receptor γ coactivator 1-α (PPARGC1A), a gene that plays a key role in insulin-mediated glucose uptake [95].…”

Section: Differentially Expressed and Dispersed Mirnas Are Related Wimentioning

confidence: 99%

Co-expression network analysis predicts a key role of microRNAs in the adaptation of the porcine skeletal muscle to nutrient supply

Mármol-Sánchez

Ramayo-Caldas

Quintanilla

et al. 2020

J Animal Sci Biotechnol

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Background: The role of non-coding RNAs in the porcine muscle metabolism is poorly understood, with few studies investigating their expression patterns in response to nutrient supply. Therefore, we aimed to investigate the changes in microRNAs (miRNAs), long intergenic non-coding RNAs (lincRNAs) and mRNAs muscle expression before and after food intake. Results: We measured the miRNA, lincRNA and mRNA expression levels in the gluteus medius muscle of 12 gilts in a fasting condition (AL-T0) and 24 gilts fed ad libitum during either 5 h. (AL-T1, N = 12) or 7 h. (AL-T2, N = 12) prior to slaughter. The small RNA fraction was extracted from muscle samples retrieved from the 36 gilts and sequenced, whereas lincRNA and mRNA expression data were already available. In terms of mean and variance, the expression profiles of miRNAs and lincRNAs in the porcine muscle were quite different than those of mRNAs. Food intake induced the differential expression of 149 (AL-T0/AL-T1) and 435 (AL-T0/AL-T2) mRNAs, 6 (AL-T0/AL-T1) and 28 (AL-T0/AL-T2) miRNAs and none lincRNAs, while the number of differentially dispersed genes was much lower. Among the set of differentially expressed miRNAs, we identified ssc-miR-148a-3p, ssc-miR-22-3p and ssc-miR-1, which play key roles in the regulation of glucose and lipid metabolism. Besides, co-expression network analyses revealed several miRNAs that putatively interact with mRNAs playing key metabolic roles and that also showed differential expression before and after feeding. One case example was represented by seven miRNAs (ssc-miR-148a-3p, ssc-miR-151-3p, ssc-miR-30a-3p, ssc-miR-30e-3p, ssc-miR-421-5p, ssc-miR-493-5p and ssc-miR-503) which putatively interact with the PDK4 mRNA, one of the master regulators of glucose utilization and fatty acid oxidation. Conclusions: As a whole, our results evidence that microRNAs are likely to play an important role in the porcine skeletal muscle metabolic adaptation to nutrient availability.

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“…The interaction of BACH1 with heme via its heme-binding site results in proteasome-dependent degradation of this protein [65], and the subsequent activation of genes which are repressed by BACH1. Although, BACH1 has initially been identified as a transcriptional regulator of HO-1 [66], recent studies have indicated that it controls various aspects of cellular function such as bioenergetics [67], cell cycle [68], and macrophage differentiation [69]. Specifically, in monocytes BACH1 was also shown to be involved in the subtype specification of lymphocyte antigen 6C (Ly6C)+ (inflammatory) and Ly6C-(patrolling) monocytes, the underlying mechanisms of which are yet to be characterized [70].…”

Section: Intracellular Labile Heme Controls Cellular Functions Via Hementioning

confidence: 99%

Interplay of Heme with Macrophages in Homeostasis and Inflammation

Pradhan

Vijayan

Gueler

et al. 2020

IJMS

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Macrophages are an integral part of the mononuclear phagocyte system that is critical for maintaining immune homeostasis. They play a key role for initiation and modulation of immunological responses in inflammation and infection. Moreover, macrophages exhibit a wide spectrum of tissue-specific phenotypes in steady-state and pathophysiological conditions. Recent clinical and experimental evidence indicates that the ubiquitous compound heme is a crucial regulator of these cells, e.g., in the differentiation of monocytes to tissue-resident macrophages and/ or in activation by inflammatory stimuli. Notably, heme, an iron containing tetrapyrrole, is essential as a prosthetic group of hemoproteins (e.g., hemoglobin and cytochromes), whereas non-protein bound free or labile heme can be harmful via pro-oxidant, pro-inflammatory, and cytotoxic effects. In this review, it will be discussed how the complex interplay of heme with macrophages regulates homeostasis and inflammation via modulating macrophage inflammatory characteristics and/ or hematopoiesis. A particular focus will be the distinct roles of intra- and extracellular labile heme and the regulation of its availability by heme-binding proteins. Finally, it will be addressed how heme modulates macrophage functions via specific transcriptional factors, in particular the nuclear repressor BTB and CNC homologue (BACH)1 and Spi-C.

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Bach1: Function, Regulation, and Involvement in Disease

Cited by 119 publications

References 74 publications

The BACH1/Nrf2 Axis in Brain in Down Syndrome and Transition to Alzheimer Disease-Like Neuropathology and Dementia

The BACH1/Nrf2 Axis in Brain in Down Syndrome and Transition to Alzheimer Disease-Like Neuropathology and Dementia

Co-expression network analysis predicts a key role of microRNAs in the adaptation of the porcine skeletal muscle to nutrient supply

Interplay of Heme with Macrophages in Homeostasis and Inflammation

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