BacFlash signals acid-resistance gene expression in bacteria

Intermittent proton bursts of single lactic acid bacteria

“…16,17 It has been reported to be involved in regulating bacterial intracellular pH as well as reactive oxygen levels. 18 Our recent studies on bioluminescent bacteria, P. phosphoreum, have shown that the uctuations in the activity of the Na + /H + antiporter led to an intermittently pulsed behavior of the membrane potential, as revealed by the blinking bioluminescence emission of a single bacterium. 8 Although current research studies have shed light on the membrane potential dynamics of bacteria in multiple dimensions, new perspectives are still expected.…”

Charge Neutralization Strategy to Construct Salt-Tolerant and Cell-Permeable Nanoprobes: Application in Ratiometric Sensing and Imaging of Intracellular pH

“…The balance of intracellular pH is essential for maintaining normal physiological processes in cells and organisms. − In normal mammalian cells, intracellular pH varies from 4.5 (lysosomes) to 8.0 (mitochondria). − Abnormalities in intracellular pH regulation are frequently associated with cellular injury/dysfunction, which would cause various diseases such as cancers, neurodegenerative disorders, and vascular diseases. − Determination of pH changes in living cells is of great importance for a better understanding of pH-related physiological and pathological processes, as well as providing a good reference for the diagnosis and treatment of some diseases. , …”