BABY BOOM regulates early embryo and endosperm development

Chen, Baojian; Maas, Lena; Figueiredo, Duarte D.; Zhong, Yu; Reis, Robert L.; Li, Mengran; Horstman, Anneke; Riksen, Tjitske; Weemen, Mieke; Liu, Huan; Siemons, Charlotte; Chen, Shaojiang; Angenent, Gerco C.; Boutilier, Kim

doi:10.1073/pnas.2201761119

Cited by 35 publications

(57 citation statements)

References 94 publications

(130 reference statements)

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“…BBM, an AINTEGUMENTA-like (AIL) transcription factor, belongs to the APETALA2/ETHYLENE RESPONSE FACTOR (AP2/ERF) family, which was previously shown to play a critical role in inducing or enhancing somatic embryogenesis [ 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 ]. In addition to triggering somatic embryogenesis, recent studies have demonstrated that the ectopic expression of BBM in egg cells can trigger egg cells to initiate embryogenesis in multiple sexual plants [ 93 , 94 , 95 , 96 , 97 , 98 , 99 ], indicating the conserved role of BBM in promoting embryogenesis. For example, in rice, the ectopic expression of BBM1 in egg cells can produce embryo-like structures without fertilization [ 96 ].…”

Section: Transcription Factors Triggered Haploid Embryogenesismentioning

confidence: 99%

The Roads to Haploid Embryogenesis

Shen

Zhao

2023

Plants

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Although zygotic embryogenesis is usually studied in the field of seed biology, great attention has been paid to the methods used to generate haploid embryos due to their applications in crop breeding. These mainly include two methods for haploid embryogenesis: in vitro microspore embryogenesis and in vivo haploid embryogenesis. Although microspore culture systems and maize haploid induction systems were discovered in the 1960s, little is known about the molecular mechanisms underlying haploid formation. In recent years, major breakthroughs have been made in in vivo haploid induction systems, and several key factors, such as the matrilineal (MTL), baby boom (BBM), domain of unknown function 679 membrane protein (DMP), and egg cell-specific (ECS) that trigger in vivo haploid embryo production in both the crops and Arabidopsis models have been identified. The discovery of these haploid inducers indicates that haploid embryogenesis is highly related to gamete development, fertilization, and genome stability in ealry embryos. Here, based on recent efforts to identify key players in haploid embryogenesis and to understand its molecular mechanisms, we summarize the different paths to haploid embryogenesis, and we discuss the mechanisms of haploid generation and its potential applications in crop breeding. Although these haploid-inducing factors could assist egg cells in bypassing fertilization to initiate embryogenesis or trigger genome elimination in zygotes after fertilization to form haploid embryos, the fertilization of central cells to form endosperms is a prerequisite step for haploid formation. Deciphering the molecular and cellular mechanisms for haploid embryogenesis, increasing the haploid induction efficiency, and establishing haploid induction systems in other crops are critical for promoting the application of haploid technology in crop breeding, and these should be addressed in further studies.

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Section: Transcription Factors Triggered Haploid Embryogenesismentioning

confidence: 99%

The Roads to Haploid Embryogenesis

Shen

Zhao

2023

Plants

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“…PLT1 / AIL3 and PLT2 / AIL4 also play essential roles in the quiescent center specification and stem cells maintenance ( Aida et al., 2004 ). BBM / AIL2 is involved in the embryo and endosperm development, and ectopic expression of BBM / AIL2 leads to the production of somatic embryos on seedlings ( Boutilier et al., 2002 ; Chen et al., 2022 ). Moreover, AIL5 , AIL6 , and AIL7 execute an extra function in phyllotaxy stability and lateral root emergence ( Prasad et al., 2011 ; Hofhuis et al., 2013 ; Pinon et al., 2013 ).…”

Section: Introductionmentioning

confidence: 99%

Genome-wide characterization of AINTEGUMENTA-LIKE family in Medicago truncatula reveals the significant roles of AINTEGUMENTAs in leaf growth

Wang

Zhang

et al. 2022

Front. Plant Sci.

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AINTEGUMENTA-LIKE (AIL) transcription factors are widely studied and play crucial roles in plant growth and development. However, the functions of the AIL family in legume species are largely unknown. In this study, 11 MtAIL genes were identified in the model legume Medicago truncatula, of which four of them are MtANTs. In situ analysis showed that MtANT1 was highly expressed in the shoot apical meristem (SAM) and leaf primordium. Characterization of mtant1 mtant2 mtant3 mtant4 quadruple mutants and MtANT1-overexpressing plants revealed that MtANTs were not only necessary but also sufficient for the regulation of leaf size, and indicated that they mainly function in the regulation of cell proliferation during secondary morphogenesis of leaves in M. truncatula. This study systematically analyzed the MtAIL family at the genome-wide level and revealed the functions of MtANTs in leaf growth. Thus, these genes may provide a potential application for promoting the biomass of legume forages.

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“…Extensive genomic and transcriptomic studies have been conducted on BBM in a variety of crops to determine and establish its function and the genes it regulates. Despite these advances and potential applications limited information is available on BBM’s role and mechanism of action during embryogenesis [ 28 ]. Deciphering the structure of BBM protein and predicting its interactions is critical for functional characterization and determination of interacting partners and/or ligands.…”

Section: Introductionmentioning

confidence: 99%

BabyBoom: 3-Dimensional Structure-Based Ligand and Protein Interaction Prediction by Molecular Docking

Panchangam¹

2022

Biomolecules

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Baby Boom (BBM) is a key transcription factor that triggers embryogenesis, enhances transformation and regeneration efficiencies, and regulates developmental pathways in plants. Triggering or activating BBM in non-model crops could overcome the bottlenecks in plant breeding. Understanding BBM’s structure is critical for functional characterization and determination of interacting partners and/or ligands. The current in silico study aimed to study BBM’s sequence and conservation across all plant proteomes, predict protein-protein and protein-ligand interactions, and perform molecular docking and molecular dynamics (MD) simulation to specifically determine the binding site amino acid residues. In addition, peptide sequences that interact with BBM have also been predicted, which provide avenues for altered functional interactions and the design of peptide mimetics that can be experimentally validated for their role in tissue culture or transformation media. This novel data could pave the way for the exploitation of BBM’s potential as the master regulator of specialized plant processes such as apomixes, haploid embryogenesis, and CRISPR/Cas9 transgenic development.

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BABY BOOM regulates early embryo and endosperm development

Cited by 35 publications

References 94 publications

The Roads to Haploid Embryogenesis

The Roads to Haploid Embryogenesis

Genome-wide characterization of AINTEGUMENTA-LIKE family in Medicago truncatula reveals the significant roles of AINTEGUMENTAs in leaf growth

BabyBoom: 3-Dimensional Structure-Based Ligand and Protein Interaction Prediction by Molecular Docking

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