Baboons in Drug Abuse Research

Hienz, Robert D.; Weerts, Elise M.

doi:10.1007/978-0-387-75991-3_16

Cited by 1 publication

(2 citation statements)

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“…1–5 The smaller invertebrates such as Drosophila melanogaster (fruit fly) have also been heavily used as a model in neuroscience and to study drugs of abuse. 6–8 We have used the fly model to study the effects of methylphenidate on the actions of cocaine at dopamine neurons.…”

Section: Introductionmentioning

confidence: 99%

“…A wealth of studies have been carried out on animal models, including rats, mice, baboons, and monkeys, to investigate neurochemical changes in the central nervous system associated with drug action and addiction. − The smaller invertebrates such as Drosophila melanogaster (fruit fly) have also been heavily used as models in neuroscience and to study drugs of abuse. − We have used the fly model to study the effects of methylphenidate on the actions of cocaine at the dopamine neurons …”

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confidence: 99%

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Capillary Electrophoresis–Mass Spectrometry-Based Detection of Drugs and Neurotransmitters in Drosophila Brain

et al. 2013

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Capillary electrophoresis coupled to mass spectrometry has been used to determine the in vivo concentrations of the neuroactive drug, methylphenidate, and a metabolite in the heads of the fruit fly, Drosophila melanogaster. These concentrations, evaluated at the site of action, the brain, have been correlated with orally administrated methylphenidate. Drosophila melanogaster has a relatively simple nervous system but possesses high order brain functions similar to humans; thus it has been used as a common model system in biological and genetics research. Methylphenidate has been used to mediate cocaine addiction due to its lower pharmacokinetics, which results in fewer addictive and reinforcing effects than cocaine; the effects of the drug on the nervous system, however, have not been fully understood. In addition to measurements of drug concentration, the method has been used to examine drug dose dependence on the levels of several primary biogenic amines. Higher in vivo concentration of methylphenidate is observed with increasing feeding doses up to 25 mM methylphenidate. Furthermore, administrated methylphenidate increases the drug metabolism activity and the neurotransmitter levels; however, this increase appears to saturate at a feeding dose of 20 mM. The method developed for the fruit fly provides a new tool to evaluate the concentration of administered drug at the site of action and provides information concerning the effect of methylphenidate on the nervous system.

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