Baboon Bone Marrow Transplantation in Humans: Application of Cross‐Species Disease Resistance

Exner, Beate G.; Neipp, Michael; Ildstad, Suzanne T.

doi:10.1007/s002689900334

Cited by 12 publications

(5 citation statements)

References 59 publications

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“…For example, following pig‐to‐baboon organ Tx, porcine cytomegalovirus has not been documented to infect the host baboon, and baboon cytomegalovirus has not been seen to infect the transplanted pig organ 102, 103. Baboon livers were transplanted into 2 patients in Pittsburgh as a means of avoiding hepatitis B recurrence,21 and baboon bone marrow Tx has been explored as a means of avoiding reinfection of human immune system cells by human immunodeficiency virus 104, 105…”

Section: Commentmentioning

confidence: 99%

Laryngeal cancer involving a branchial cleft cyst

et al. 2011

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Section: Commentmentioning

confidence: 99%

Laryngeal cancer involving a branchial cleft cyst

et al. 2011

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“…102,103 Baboon livers were transplanted into 2 patients in Pittsburgh as a means of avoiding hepatitis B recurrence, 21 and baboon bone marrow Tx has been explored as a means of avoiding reinfection of human immune system cells by human immunodeficiency virus. 104,105 We have also not considered the potential incompatibilities between pig and human hepatic function. With the exception of reviews by Hammer and Platt and their respective colleagues, 84,[106][107][108] most aspects of physiologic compatibility between pigs and humans have been sparsely investigated or not investigated at all.…”

Section: Commentmentioning

confidence: 99%

Liver xenografts for the treatment of acute liver failure: Clinical and experimental experience and remaining immunologic barriers

et al. 2008

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A critical element restricting the application of liver transplantation is the shortage of human deceased donor organs. Xenotransplantation using pig organs might be a solution to this shortage. Although the problems that still require resolution include the immunologic barrier, the potential risk of transferring infectious agents with the transplanted organ, and uncertainty about whether the transplanted organ will function satisfactorily in the human environment, recent progress in the genetic manipulation of pigs has led to the prospect that clinical xenografting, at least as a bridge to allotransplantation, may be possible in the foreseeable future. Experience with clinical auxiliary and orthotopic liver xenotransplantation and experimental liver xenotransplantation in nonhuman primate and other large animal models is reviewed, and the remaining immunologic problems are discussed. Evidence suggests that, in patients with hepatic failure, the pig liver may be less susceptible to antibody-mediated injury than other pig organs, such as the heart or kidney. Pig Kupffer cells and other macrophages will recognize and phagocytose primate red blood cells, but this problem should be overcome by pretransplant depletion of macrophages from the organ-source pig. From the evidence currently available, it does not seem unduly optimistic to anticipate that a liver from an ␣1,3-galactosyltransferase gene-knockout pig would survive at least long enough to function as a successful bridge to allotransplantation.

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“…Corneas, islets, thyroids and parathyroids have been taken into consideration. Transplantation of bone marrow has even be tried in a desperate clinical situation [10].…”

Section: Capacity Of Organsmentioning

confidence: 99%

Xenotransplantation: Perspectives and Limits

Hammer¹

2001

Blood Purif

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Xenotransplantation faces the dilemma of an unlimited supply of cells, tissues and organs on the one hand and severe obstacles and limits on the other. One reason for the limitations is that the source animal of choice, the pig, and the human recipient separated 90 million years ago during evolution, a time in which biological characteristics such as anatomy, physiology and immunology have had much time to drift far apart. The acceptance of such an evolutionary widely divergent organ, especially the heart of a pig, could evoke refusal of xenotransplantation in conservative and religious patients. New legal aspects of allocation of xenografts have therefore to be reflected upon and appropriate guidelines developed. Inquiries show, however, that the acceptance of all types of porcine organs would be high if the quality of life after receiving such a xenograft is comparable to that after receiving the same allograft. This individual benefit of a xenograft could lead to a disregard of the collective risk in terms of xenozoonoses, often presented as a catastrophic scenarium. Therefore, transplantation societies and ethics committees have published comments and even guidelines for handling future clinical xenotransplantation. All three monotheistic religions and Hinduism support the idea of saving and improving human life with the help of an animal organ.

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Baboon Bone Marrow Transplantation in Humans: Application of Cross‐Species Disease Resistance

Cited by 12 publications

References 59 publications

Laryngeal cancer involving a branchial cleft cyst

Laryngeal cancer involving a branchial cleft cyst

Liver xenografts for the treatment of acute liver failure: Clinical and experimental experience and remaining immunologic barriers

Xenotransplantation: Perspectives and Limits

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