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Synthesis of Quinazolinones, Imidazo[1,2‐c]quinazolines and Imidazo[4,5‐c]quinolines through Tandem Reductive Amination of Aryl Halides and Oxidative Amination of C(sp3)–H Bonds

“…Substrate scope for the synthesis of imidazo [1,2-c]quinazolines. [a,b] [a] Reaction conditions: 5 (0.27 mmol), 2 (2.0 mL), NaN 3 in-4(3H)-one 6a in 71 % yield. The substrate scope of this reaction was demonstrated by using N-substituted 2-bromobenzamides 5a-5h to give the corresponding quinazolin-4(3H)-ones 6a-6h in moderate to good (37-71 %) yields (Table 3).…”

“…trally acting muscle relaxant. [3] Quinazolinone derivatives are also used as tyrosine kinase inhibitors, phosphatidylinositol 3kinase (PI3K) inhibitors, and tumor necrosis factor alpha (TNFα) production inhibitors. An imidazo [4,5-c]quinoline derivative, imiquimod, is an interferon (IFN) inducer.…”

A Facile Synthesis of Quinazolin‐4(3H)‐ones via Copper‐Catalyzed One‐Pot, Three‐Component Tandem Reaction

“…[1] Compounds containing this motif have shown significant biological activities which include antiviral, anticancer, antifungal, antimalarial, anticonvulsant, antidiabetic and antimicrobial. [2] For example, rutaecarpine (A), luotonine A (B) and tryptanthrin (C) are most important active components in natural herbs while pyrido [4,3-d] pyrimidin-4(3H)-one (D) is an orally active calcium-sensing receptor antagonist, [3] afloqualone (E) is a GABAergic drug [4] and thymitaq (F) is a thymidylate synthase inhibitor which is used as anticancer agent for hepatocellular carcinoma. [5] Owing to wide range of application, several approaches have been developed for the synthesis of quinazolin-4(3H)-ones.…”