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doi:10.13040/ijpsr.0975-8232.8(2).895-99

Cited by 4 publications

(3 citation statements)

References 10 publications

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“…The gas chromatography-mass spectrometry analysis of clove oil used in this research revealed eugenol as it's constituent with the largest percentage. This is similar with previous research done by Uddin (2017) that also found eugenol to be clove oil main constituent 8 .…”

Section: Discussionsupporting

confidence: 93%

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Potential Use of Clove Oil Diluted in VCO On Contaminated Wound Healing

Primandaru,

Maulana,

Romdhoni

et al. 2023

Herb-Medicine Journal

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Essential oils, including clove oil, has been used broadly through human civilization due to its multiple benefits, including its utilization as natural antiseptics. In spite of its benefits, clove oil can cause irritation if applied neat to the skin, thus a carrier oil is needed for topical application of clove oil. Clove oil together with virgin coconut oil as a carrier, has potential synergic benefit if applied on contaminated wounds due to its enhanced antiseptic and anti-inflammatory properties. The aim of this study is to investigate the effect of topical application of clove (Syzygium aromaticum) oil diluted in Virgin Coconut Oil on contaminated wound. This study was a quasi-experimental research with post-test only control group design. Clove oil that had been diluted in VCO was applied on contaminated excisional wound in white male rat wistar strain once daily. The wound was inflicted using unsterilized scalpel. The wound was then left exposed to the environment without any dressing and the healing process was then evaluated by measuring the wound area percentage once every four days for sixteen days. Friedman analysis used in this study showed a significant result (p<0,001) and Concentration of 5% clove oil diluted in VCO was found to be the most effective concentration based on the measurement of wound area percentage on the last day of measurement. This study concludes that the topical application of clove oil diluted in VCO showed a significant difference in wound healing process.

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Section: Discussionsupporting

confidence: 93%

“…Clove oil medicinal use can be observed in many cultures across the world, it has been used as natural antiseptics and as remedy for numerous symptoms both in their topical or inhalant form 7 . It's antiseptic property, along with anti-inflammatory potency, is due to it's high eugenol content 8 .…”

Section: Introductionmentioning

confidence: 99%

Potential Use of Clove Oil Diluted in VCO On Contaminated Wound Healing

Primandaru,

Maulana,

Romdhoni

et al. 2023

Herb-Medicine Journal

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“…In in vitro studies, eugenol and eugenyl acetate suppressed IFN γ , IL-2, IL-10 levels ( Saraphanchotiwitthaya et al, 2019 ), and in in vivo studies, eugenol suppressed TNF α , IL-1 β , IL-6, and NF-kBp65 expression ( Ma et al, 2018 ). Among other chemical constituents, α -humelene is found commonly as a chemical constituent, although the percentage is low ( Jirowetz et al, 2006 ; Chaieb et al, 2007 ; Amelia et al, 2017 ; Uddin et al, 2017 ). α -Humulene is also known to have anti-inflammatory effects, suppressing the IL-5, CCL11, leukotriene B4 levels, and NF-kB and AP-1 activation ( Sa et al, 2015 ; Nuutinen, 2018 ; Kim et al, 2020 ).…”

Section: Chemical Constituents Of the Essential Oils Used In Olfactor...mentioning

confidence: 99%

Chemical Constituents of Essential Oils Used in Olfactory Training: Focus on COVID-19 Induced Olfactory Dysfunction

Koyama

Heinbockel

2022

Front. Pharmacol.

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The recent increase in the number of patients with post-viral olfactory dysfunction (PVOD) following the outbreak of COVID-19 has raised the general interest in and concern about olfactory dysfunction. At present, no clear method of treatment for PVOD has been established. Currently the most well-known method to improve the symptoms of olfactory dysfunction is “olfactory training” using essential oils. The essential oils used in olfactory training typically include rose, lemon, clove, and eucalyptus, which were selected based on the odor prism hypothesis proposed by Hans Henning in 1916. He classified odors based on six primary categories or dimensions and suggested that any olfactory stimulus fits into his smell prism, a three-dimensional space. The term “olfactory training” has been used based on the concept of training olfactory sensory neurons to relearn and distinguish olfactory stimuli. However, other mechanisms might contribute to how olfactory training can improve the recovery of the olfactory sense. Possibly, the essential oils contain chemical constituents with bioactive properties that facilitate the recovery of the olfactory sense by suppressing inflammation and enhancing regeneration. In this review, we summarize the chemical constituents of the essential oils of rose, lemon, clove, and eucalyptus and raise the possibility that the chemical constituents with bioactive properties are involved in improving the symptoms of olfactory dysfunction. We also propose that other essential oils that contain chemical constituents with anti-inflammatory effects and have binding affinity with SARS-CoV-2 can be new candidates to test their efficiencies in facilitating the recovery.

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