Abstract:OBJECTIVE
As a ligand of NKp30, B7 homolog 6 (B7-H6) is involved in the immune regulation of various tumors. The aim of this study was to clarify the effect of B7-H6 expressed in HeLa cells on NK cell killing function.
METHODS
The expression of B7H6 was changed in HeLa cells using short hairpin RNA. Furthermore the effect of B7-H6 on the killing function of NK cell was analyzed after cell co-culture. Flow cytometry was used to detect NKp30 expression, degranulation function, perforin (PFP) and Granzyme B (GZ… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.