B7-H3/CD276 Inhibitors: Is There Room for the Treatment of Metastatic Non-Small Cell Lung Cancer?

Malapelle, Umberto; Parente, Paola; Pepe, Francesco; Micco, Martina Concetta Di; Russo, Alessandro; Clemente, Celeste; Graziano, Paolo; Rossi, Antonio

doi:10.3390/ijms232416077

Cited by 6 publications

(3 citation statements)

References 35 publications

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“…It's worth noting that our results are aligned with most studies conducted on tissue specimens, where CD276 expression has consistently been correlated with a poor prognosis, underscoring the significance of our findings (Malapelle et al, 2022).…”

Section: Biomarkers With Prognostic Valuesupporting

confidence: 86%

Characterization of Tumor Cells and Immune Microenvironment Interactions in Non Small Cell Lung Cancer. Translational implications

Torres Martínez

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Y llego el día, Después de 5 años ha llegado el día en el que todo el esfuerzo, todos los obstáculos, la distancia, la soledad, la frustración, los lloros, las emociones y la desesperación han valido la pena. El día que decidí estudiar el máster en Valencia y poner 180 km de por medio no imaginé que llegaría hasta aquí. No ha sido fácil, pero de lo que sí estoy segura es que esta etapa ha supuesto un gran aprendizaje en mi vida, y todo gracias a esa gente que lo ha hecho posible.2018. Época pre-pandemia. Clase de inglés. Cuando la profesora pregunta: ¿Who do you have as a mentor or guide to follow? Mi cabeza rápidamente contestó Eloisa, mi jefa. La Dra. Eloisa ha sido siempre un ejemplo a seguir en este mundo científico tan sacrificado.Esa pasión, ese poder con todo, ese sacrificio, esa sabiduría, es lo que cualquier científico quisiera llegar a conseguir. Gracias por tu ayuda en esta andadura, por tu sabiduría, por tu apoyo, por tus sabios consejos siempre y sobre todo por tu confianza. Nunca dejaré de estar agradecida.Del mismo modo, me gustaría agradecer al Dr. Carlos Camps, mi director, al que le agradezco la confianza depositada en mí. Gracias por brindarme la oportunidad de formar parte de este gran equipo multidisciplinar y permitirme crecer cada día en el mundo de la investigación.Y por supuesto, a la Dra. Silvia Calabuig, que, siendo sincera, sin ella no hubiera podido llegar hasta aquí. Eres un gran ejemplo de sacrificio, dedicación y trabajo. No sólo has estado ahí para lo profesional, sino que siempre he sentido un apoyo para lo personal.Gracias, gracias y gracias por estar ahí siempre, por regañarnos cuando hacía falta, por animarnos cuando era necesario, por dar sin esperar recibir. Porque al fin y al cabo siempre has sido la pieza fundamental, aquella que, si falta, hace que no se pueda formar el puzle. Porque si algo se sabe es que, Silvia, siempre está al pie del cañón.

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Section: Biomarkers With Prognostic Valuesupporting

confidence: 86%

Characterization of Tumor Cells and Immune Microenvironment Interactions in Non Small Cell Lung Cancer. Translational implications

Torres Martínez

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“…CD276 is an ICP molecule and a co-stimulatory/co-inhibitory immunomodulatory protein that plays a dual role in the immune system ( 54 ); its expression in tumors is associated with poor prognosis. In addition to its role in immune regulation, it also promotes pro-tumor functions such as tumor migration, invasion, metastasis, resistance, and metabolism ( 55 ). CD276 is closely related to the invasion, metastasis, proliferation, and prognosis of NSCLC tumors.…”

Section: Discussionmentioning

confidence: 99%

Construction of a prognostic model for lung adenocarcinoma based on membrane-tension-related genes

Zhu¹,

Teng²,

Yang³

et al. 2023

J Thorac Dis

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Background: Lung adenocarcinoma (LUAD), which is the most common type of non-small cell lung cancer (NSCLC), is one of the most aggressive and fatal tumors. Therefore, the identification of key biomarkers affecting prognosis is important to improving the prognosis of patients with LUAD. Cell membranes have long been understood; however, few studies have focused on the role of membrane tension in LUAD. The present study aimed to construct a prognostic model associated with membrane-tensionrelated genes (MRGs) and explore its prognostic value in LUAD patients.Methods: RNA sequencing data and the corresponding clinical characteristics data of LUAD were obtained from The Cancer Genome Atlas (TCGA) database. Five membrane-tension prognosis-related genes (5-MRG) were screened by univariate and multifactorial COX regression and least absolute shrinkage and selection operator (LASSO) regression analyses. The data were then divided into testing, training, and all groups to build a prognostic model, and Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), copy number variations (CNV), tumor mutation burden (TMB), and tumor microenvironment (TME) analyses were performed to explore the potential mechanisms of MRGs. Finally, single-cell data from the GSE200972 dataset in the Gene Expression Omnibus (GEO) database were obtained to determine the distribution of prognostic MRGs.Results: Construction and validation of the prognostic risk models were conducted using 5-MRG in the trial, test, and all data sets. Patients in the low-risk group had a better prognosis than those in the high-risk group, and the Kaplan-Meier survival curve and receiver operating characteristic curve (ROC) confirmed that the model had a better predictive value for LUAD patients. GO and KEGG analyses of differential genes in the high-and low-risk groups were significantly enriched in immune-related pathways. Immune checkpoint (ICP) differential genes differed significantly in the high-and low-risk groups. By analyzing the single-cell sequencing data, the cells were divided into nine subpopulations and cell subpopulation localization through 5-MRG. Conclusions:The results of this study suggest that a prognostic model based on prognosis-associated MRGs can be used to predict the prognosis of LUAD patients. Therefore, prognosis-related MRGs could be potential prognostic biomarkers and therapeutic targets.

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“…B7-H3 protein is down-regulated in fibroblasts, immune cells and normal tissues, while it is overexpressed in tumor tissues, including different types of lung cancer, thus becoming an interesting and promising target in cancer immunotherapy so long as significantly contributes to the reduction of cancer cell proliferation and metastatization [ 32 , 33 ]. From an immunity perspective, its expression is found to be associated with a reduction of T-cell and interferon-γ, and hence B7-H3 blockade can stimulate an early influx of CD8+ T - cells and, consequently, promotes an antitumorigenic activity [ 23 , 30 ].…”

Section: B7-h3 Expression and Detection Methods In Lung Cancer With A...mentioning

confidence: 99%

B7-H3/CD276 and small-cell lung cancer: What's new?

Fabrizio,

Muscarella,

Rossi

2024

Translational Oncology

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B7-H3/CD276 Inhibitors: Is There Room for the Treatment of Metastatic Non-Small Cell Lung Cancer?

Cited by 6 publications

References 35 publications

Characterization of Tumor Cells and Immune Microenvironment Interactions in Non Small Cell Lung Cancer. Translational implications

Characterization of Tumor Cells and Immune Microenvironment Interactions in Non Small Cell Lung Cancer. Translational implications

Construction of a prognostic model for lung adenocarcinoma based on membrane-tension-related genes

B7-H3/CD276 and small-cell lung cancer: What's new?

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