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Lee, Ji; Kim, Hyung L.; Jung, Jong Jae; Kim, Young; Lee, Min; Park, Chang

doi:10.1097/00022744-200212000-00001

Cited by 19 publications

(20 citation statements)

References 30 publications

(51 reference statements)

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“…However, HPV infection alone is not sufficient for neoplastic progression in humans; the HPV-infected cell must undergo additional genetic changes. Moreover, the type I tyrosine kinase receptor ErbB-2 is overexpressed in at least 30% of HN cancers and CxCa (Xia et al, 1997;Wilkman et al, 1998;Ibrahim et al, 1999;Lee et al, 2002). No studies have been performed that address the potential importance of the combined effect of HPV and ErbB-2 in HN cancer.…”

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confidence: 99%

Cyclin D1 is essential for neoplastic transformation induced by both E6/E7 and E6/E7/ErbB-2 cooperation in normal cells

et al. 2004

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More than 25% of head and neck squamous cell carcinomas (HNSCC) and 99% of cervical cancers (CxCa) are positive for high-risk human papillomaviruses (HPVs). Furthermore, the type I tyrosine kinase receptor ErbB-2 is overexpressed in at least 30% of HNSCC and CxCa. Recently, we demonstrated that E6/E7 of HPV type 16 cooperate with ErbB-2 to induce cell transformation of human normal oral epithelial (NOE) cells. This is accompanied by overexpression of cyclin D1 in NOE cells. To determine the role of cyclin D1 in E6/E7/ErbB-2 cooperation, we examined the independent effects of E6/E7 and ErbB-2, and the combined effect of E6/E7 and ErbB-2 in mouse normal embryonic fibroblast (NEF), wild type (wt), and knockout cyclin D1 (D1 À/À ) cells. We report that NEF-wt cells transduced with E6/E7 alone and E6/E7/ErbB-2 together form small and large tumors in nude mice, respectively, as well as different sized colonies in soft agar; whereas ErbB-2 alone elicits neither tumor formation in vivo nor colony formation in soft agar. More importantly, E6/E7, ErbB-2 and E6/E7/ErbB-2 together all fail to induce neoplastic transformation of cyclin D1 À/À cells in vivo and in vitro. Furthermore, using antisense cyclin D1 we completely inhibited tumor and colony formation of NEF-wt-E6/E7 and wt-E6/E7-ErbB-2 as well as human NOE-E6/E7-ErbB-2-transformed cells. These analyses reveal that cyclin D1 is the downstream target of the neoplastic transformation induced by E6/E7 or E6/E7/ErbB-2 cooperation in normal cells. Our data suggest that anti-cyclin D1 therapy may be highly specific in the treatment of all human cancers expressing high-risk HPVs or HPVs/ErbB-2.Oncogene ( Keywords: cyclin D1; E6/E7 of HPV; ErbB-2; cell transformation Head and neck (HN) cancer is the sixth most common neoplasm in the world today in both men and women (Gasco and Crook, 2003). Cervical carcinoma (CxCa) is the second most common cancer among women worldwide and the most frequent female cancer in large areas of the developing world (Clifford et al., 2003). The overall 5-year survival rate of patients diagnosed with HN cancer or CxCa is approximately 60% and has not significantly improved over the past two decades. An important etiological factor is the human papillomavirus (HPV), as roughly 25% of HN cancers and 99% of CxCa are positive for high-risk HPVs (types 16 and 18) (Ke et al., 1999;Gillison et al., 2000;Niv et al., 2000;Moreno et al., 2002). The high-risk HPV E6 and E7 oncoproteins, which are constitutively expressed in these cancers, inactivate the p53 and pRb tumor suppressors, respectively. However, HPV infection alone is not sufficient for neoplastic progression in humans; the HPV-infected cell must undergo additional genetic changes. Moreover, the type I tyrosine kinase receptor ErbB-2 is overexpressed in at least 30% of HN cancers and CxCa (Xia et al., 1997;Wilkman et al., 1998;Ibrahim et al., 1999;Lee et al., 2002). No studies have been performed that address the potential importance of the combined effect of HPV and ErbB-2 in HN cancer.Earlier stud...

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confidence: 99%

Cyclin D1 is essential for neoplastic transformation induced by both E6/E7 and E6/E7/ErbB-2 cooperation in normal cells

et al. 2004

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“…Previous studies showed that despite the lattice mismatch (14.6%) between CdTe and GaAs, it was possible to grow homooriented CdTe layers on the (001) GaAs substrates [12]. This means that the polycrystalline structure of CdTe on (001) Si was not caused only by the large lattice mismatch.…”

Section: Resultsmentioning

confidence: 98%

Epitaxial growth of CdTe films on GaAs-buffered (001) Si substrates by metal organic chemical vapor deposition

et al. 2012

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“…Moreover, both the mean pore size and maximum pore size of the PFFSs were smaller than those of PSUFS‐15 due to the addition of PVDF nanofiber networks (Figure 3c and Figure S8, Supporting Information; see details in the Supplementary Discussion section in the Supporting Information), which further improved the complexity of the channels, thus extending the sound transmission length and resulting in more energy losses. [ 44,45 ]…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, both the mean pore size and maximum pore size of the PFFSs were smaller than those of PSUFS-15 due to the addition of PVDF nanofiber networks (Figure 3c and Figure S8, Supporting Information; see details in the Supplementary Discussion section in the Supporting Information), which further improved the complexity of the channels, thus extending the sound transmission length and resulting in more energy losses. [44,45] Considering the practical applications, the PFFSs must be mechanically robust to withstand a certain external force suffered in the process of the packaging, transportation, and applications. The compression performance of PSUFS-15 and the PFFSs under a larger compression strain (60%) is shown in Figure 3d.…”

Section: Fabrication and Structure Stability Of Pffssmentioning

confidence: 99%

Interlocked Dual‐Network and Superelastic Electrospun Fibrous Sponges for Efficient Low‐Frequency Noise Absorption

Zong

Cao

et al. 2020

Small Structures

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Traffic noise is a major source of urban noise pollution, with severe threats to the physiological and psychological health of humans. Fibrous sound absorption materials are extensively applied in the control of traffic noise pollution; however, the larger fiber diameters and monotonous internal structure of such materials result in poor low‐frequency sound‐absorbing properties or unsatisfied mechanical properties. Herein, a biomimetic and robust strategy to design ultrastrong and superelastic fibrous sound absorption sponges is reported, which is achieved by integrating a one‐step forming technique of interlocked micro/nano dual fiber networks and an in situ crosslinking approach. The obtained vine‐like interlocked structured fibrous sponges can withstand a tensile force 10 000 times their weight without deformation. Furthermore, the materials also show outstanding compression fatigue resistance and a lightweight feature (8.70 mg cm−3). Most importantly, the interlocked dual‐network‐induced stable fluffy‐stacked structure endows the fibrous sponges with an enhanced low‐frequency sound‐absorbing property (absorption coefficient of 0.93 at 1000 Hz), which is superior to those of commercial and reported sound absorption materials. In addition, the materials also possess good hydrophobicity and temperature resistance. This work opens new pathways for the further development of highly efficient sound‐absorbing materials.

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Cited by 19 publications

References 30 publications

Cyclin D1 is essential for neoplastic transformation induced by both E6/E7 and E6/E7/ErbB-2 cooperation in normal cells

Cyclin D1 is essential for neoplastic transformation induced by both E6/E7 and E6/E7/ErbB-2 cooperation in normal cells

Epitaxial growth of CdTe films on GaAs-buffered (001) Si substrates by metal organic chemical vapor deposition

Interlocked Dual‐Network and Superelastic Electrospun Fibrous Sponges for Efficient Low‐Frequency Noise Absorption

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