B vitamin supplementation improves cognitive function in the middle aged and elderly with hyperhomocysteinemia

Cheng, Dazhi; Kong, H. S.; Pang, Wei Wei; Yang, Hongpeng; Lu, Hao; Huang, Chengyu; Jiang, Yugang

doi:10.1179/1476830514y.0000000136

Cited by 56 publications

(48 citation statements)

References 24 publications

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“…Twenty-three studies with 6906 participants focused on B vitamins were included. Of these, one was a quasi-experimental pre-test-post-test control group design [22], one was a placebo-controlled trial allocated on matching principle [23], and the others were randomized, placebo-controlled designs. Two were letters to the editor [24,25], one was printed in proceedings [26] and the others were full articles formally published in journals.…”

Section: B Vitaminsmentioning

confidence: 99%

“…As for the dosage and ingredient of B vitamin supplementation, 13 studies reported the use of folate (400 to 5000 µg), vitamin B6 (3 to 50 mg), and vitamin B12 (20 to 1000 µg) simultaneously [22][23][24]26,[28][29][30][32][33][34][35][36][37], with two of them using riboflavin as well (10 and 25 mg, respectively) [26,29]. Four studies used folate (400 to 5000 µg) and vitamin B12 (25 to 1500 µg) concurrently [27,[38][39][40].…”

Section: B Vitaminsmentioning

confidence: 99%

“…As for sex distribution, one study had only females [28], and two studies included only males [33,43]. Four studies included individuals younger than 60 years old [23,30,36,41]. One study examined participants with normal cognitive function at baseline [25] while another five studies investigated those with MCI at baseline [24,27,32,37,42].…”

Section: B Vitaminsmentioning

confidence: 99%

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Efficacy of Vitamins on Cognitive Function of Non-Demented People: A Systematic Review and Meta-Analysis

et al. 2020

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Previous evidence has suggested that vitamins might be beneficial for cognition. This systematic review aimed to investigate the efficacy of B vitamins, antioxidant vitamins, and vitamin D on the cognitive function of non-demented middle-aged or older people. Randomized or quasi-randomized controlled trials of individuals aged 40 years or older were included. PubMed/MEDLINE, EMBASE, CINAHL, PsycINFO, Cochrane Library databases, and other grey literature sources were searched up to November 2019. Their methodological quality was evaluated using the Cochrane Risk of Bias tool. Twenty-three studies on B vitamins (n = 22–1053; comprising folate, B6, and B12), nine on antioxidant vitamins (n = 185–20,469), and six on vitamin D (n = 55–4122) were included. Taking B vitamins for over 3 months was beneficial for global cognition (standardized mean difference (SMD) −0.18, 95% CI −0.30 to −0.06) and episodic memory (SMD −0.09, 95% CI −0.15 to −0.04). However, antioxidant vitamins (SMD −0.02, 95% CI −0.08 to 0.03) and vitamin D (SMD −0.06, 95% CI −0.36 to 0.23) were not. Antioxidant vitamins were beneficial for global cognition in sensitivity analyses using final measurement data as mean difference estimates (SMD, −0.04, 95% CI −0.08 to −0.01). Taking B vitamins and possibly antioxidant vitamins may be beneficial for the cognitive function of non-demented people.

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Section: B Vitaminsmentioning

confidence: 99%

Section: B Vitaminsmentioning

confidence: 99%

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Efficacy of Vitamins on Cognitive Function of Non-Demented People: A Systematic Review and Meta-Analysis

et al. 2020

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“…96 Similarly, supplementation with B-vitamin supplements has not been effective except in cases of clear vitamin B deficiency or in countries where bread is not fortified with folate. 94,97–100 Preclinical studies have shown that a combination of nutrients involved in the Kennedy pathway for biosynthesis of neuronal membranes (including uridine monophosphate, choline and phospholipids) increased surrogate markers for synapse formation. In addition, in vivo studies showed that dietary enrichment with these nutrients improved neurotransmission, learning, and memory.…”

Section: Potential Benefits Of Early Diagnosis Of Cognitive Impairmentmentioning

confidence: 99%

Brain Health: The Importance of Recognizing Cognitive Impairment: An IAGG Consensus Conference

Morley

Morris²,

Berg‐Weger

et al. 2015

Journal of the American Medical Directors Association

236

163

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Cognitive impairment creates significant challenges for patients, their families and friends, and clinicians who provide their health care. Early recognition allows for diagnosis and appropriate treatment, education, psychosocial support, and engagement in shared decision-making regarding life planning, health care, involvement in research, and financial matters. An IAGG-GARN consensus panel examined the importance of early recognition of impaired cognitive health. Their major conclusion was that case-finding by physicians and health professionals is an important step toward enhancing brain health for aging populations throughout the world. This conclusion is in keeping with the position of the United States’ Centers for Medicare and Medicaid Services that reimburses for detection of cognitive impairment as part the of Medicare Annual Wellness Visit and with the international call for early detection of cognitive impairment as a patient’s right. The panel agreed on the following specific findings: (1) validated screening tests are available that take 3 to 7 minutes to administer; (2) a combination of patient- and informant-based screens is the most appropriate approach for identifying early cognitive impairment; (3) early cognitive impairment may have treatable components; and (4) emerging data support a combination of medical and lifestyle interventions as a potential way to delay or reduce cognitive decline.

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“…Cheng et al [37] investigated also demonstrated that supplement folic acid, vitamin B 12 in patients with HHcy could reduce Hcy levels. Our study revealed that the levels of folic acid and vitamin B 12 in AMI and in UAP patients were obviously lower compared to those in SAP and non-CAD patients (p<0.05).…”

Section: Discussionmentioning

confidence: 99%

High Homocysteine Levels are Closely Associated with the Categories of Coronary Artery Diseases as well as Low Status of Folic Acid and Vitamin B12

Ma¹,

Peng²

2016

J Hypertens (Los Angel)

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B vitamin supplementation improves cognitive function in the middle aged and elderly with hyperhomocysteinemia

Abstract: The results demonstrated that supplement containing folate, vitamin B, and vitamin B in middle-aged and elderly patients with hyperhomocysteinemia could improve their cognitive function partly and reduce serum tHcy levels.

Cited by 56 publications

References 24 publications

Efficacy of Vitamins on Cognitive Function of Non-Demented People: A Systematic Review and Meta-Analysis

Efficacy of Vitamins on Cognitive Function of Non-Demented People: A Systematic Review and Meta-Analysis

Brain Health: The Importance of Recognizing Cognitive Impairment: An IAGG Consensus Conference

High Homocysteine Levels are Closely Associated with the Categories of Coronary Artery Diseases as well as Low Status of Folic Acid and Vitamin B12

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