B-vitamin interventions for women and children in low-income populations

Swaminathan, Sumathi; Thomas, Tinku; Kurpad, Anura V

doi:10.1097/mco.0000000000000166

Cited by 21 publications

(15 citation statements)

References 27 publications

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“…Vitamin B 12 is an important micronutrient found only in animal food sources and is required for complete brain development and cognition (Rathod, Kale, & Joshi, ). Several studies conducted in developing countries have reported a high prevalence of vitamin B 12 deficiency in children and attributed to inadequate vitamin B 12 intake (Finkelstein, Layden, & Stover, ; Swaminathan, Thomas, & Kurpad, ; Venkatramanan, Armata, Struppm, & Finkelstein, ). Vitamin B 12 deficiency is associated with poor cognitive development and growth in children (Strand et al, ; Moore et al, ; Van de Rest et al, ), and vitamin B 12 status in infancy have been associated with development and performance on neuropsychological tests after 5 years (Kvestad et al, ).…”

Section: Introductionmentioning

confidence: 99%

The relationship between dietary micronutrients intake and cognition test performance among school‐aged children in government‐owned primary schools in Kumasi metropolis, Ghana

Annan

Apprey

Asamoah-Boakye

et al. 2019

Food Science & Nutrition

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Nutrients are critical for optimal brain development, and good nutritional status is associated with cognitive development and improvement. The relationship between micronutrients intake and cognition in Ghanaian school‐aged children has not been studied. The study investigated dietary intakes of micronutrients and cognition test performance of school‐aged children. A cross‐sectional study was undertaken among 438 school children, aged 9–13 years from ten randomly selected basic schools in Kumasi, Ghana. Socio‐demographic data were obtained from a structured questionnaire. Dietary intakes of iron, zinc, vitamin B6, folate, vitamin B12, and vitamin A were determined from repeated 24‐hr dietary recall data from 351 children, while cognition test was performed using a Raven's Coloured Progressive Matrices (RCPM), a 36‐question test. Among 351 children, 156 (44.4%) had inadequate zinc intake, whereas 96 (27.4%) had inadequate iron intake. More than 1 in 2 children had inadequate vitamin A intake while 55.8% and 53.0% had inadequate vitamin B12 and folate intakes, respectively. More school‐aged boys (66.3%) than girls (46.8%) had inadequate vitamin B12 intake (χ2 = 13.393, p < .001), while for iron, folate, vitamin B6, zinc, and vitamin A, the differences were not significant. Mean RCPM test score differed significantly between school type (p < .001), but did not differ between the different ages, and between children with adequate and inadequate iron, zinc, vitamin B12, vitamin B6, and vitamin A intakes, except for folate intake (p = .050). Weak positive significant associations were observed between RCPM test score and zinc and folate intakes (p = .050). Dietary micronutrient intakes were inadequate in majority of these children, which put them at risk of weakened immune system and poor health, but did not show significant associations with RCPM performance. Further studies using other forms of cognition tests may help confirm our findings, and provide the impetus for the necessary interventions.

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Section: Introductionmentioning

confidence: 99%

The relationship between dietary micronutrients intake and cognition test performance among school‐aged children in government‐owned primary schools in Kumasi metropolis, Ghana

Annan

Apprey

Asamoah-Boakye

et al. 2019

Food Science & Nutrition

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“…Vitamin B-12 is an essential B vitamin that plays an integral role in DNA synthesis, methylation reactions, and maintenance of genomic stability (1,2). Cobalamin is a cofactor for methionine synthase, an enzyme that converts 5-methyltetrahydrofolate to tetrahydrofolate via remethylation of homocysteine (tHcy) 7 to methionine (3). Methionine synthase is required for the production of S-adenosylmethionine, which is involved in >100 methylation reactions in the body and is an important methyl donor for neurotransmitter synthesis and maintenance of cellular integrity (4).…”

Section: Introductionmentioning

confidence: 99%

“…Individuals with a low intake of meat and dairy products, such as vegans and vegetarians, are at high risk of vitamin B-12 deficiency (5). Several studies conducted in low-and middleincome countries also have reported a high prevalence of vitamin B-12 deficiency, particularly in pregnant women and young children (6), in part due to inadequate dietary vitamin B-12 intake (7,8), increased requirements during pregnancy and lactation, and low vitamin B-12 content and bioavailability in breast milk (9). Micronutrient supplementation is a common strategy to prevent and treat cobalamin deficiency (10), and there is emerging interest in mandatory food fortification with vitamin B-12 (11).…”

Section: Introductionmentioning

confidence: 99%

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Vitamin B-12 and Cognition in Children

Venkatramanan¹,

Armata²,

Strupp

et al. 2016

Advances in Nutrition

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Vitamin B-12 is essential for brain development, neural myelination, and cognitive function. Inadequate vitamin B-12 status during pregnancy and early childhood has been associated with adverse child health outcomes, including impaired cognitive development. However, the underlying mechanisms have not been elucidated. This review was conducted to examine the evidence that links vitamin B-12 and cognition in children. The search strategy resulted in 17 studies: 3 cross-sectional, 1 case-control, and 12 cohort studies, and 1 randomized trial. Cognitive processes assessed included attention, memory, and perception. Developmental outcomes, academic performance, and intelligence quotient were also considered. Despite the high prevalence of vitamin B-12 insufficiency and associated risk of adverse cognitive outcomes in children, to our knowledge, no studies to date have been conducted to examine the effects of vitamin B-12 supplementation on cognition in children. The role of vitamin B-12 in the etiology of child cognitive outcomes needs to be elucidated to inform public health interventions. Adv Nutr 2016;7:879-88.

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“…Thus, during the last decade, there has been a growing awareness of the need for food fortification or supplementation of the diet with vitamin pills in such populations [7,8]. Biochemically, B12 deficiency causes a decline in serum cobalamin (Cbl) and holotranscobalamin (holoTC); also called "active" B12, because this protein-B12 complex ensures transport of the vitamin into the cells.…”

Section: Introductionmentioning

confidence: 99%

Effect of 8-week oral supplementation with 3-µg cyano-B12 or hydroxo-B12 in a vitamin B12-deficient population

et al. 2017

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Purpose We compare the effect of 8-week oral supplementation with cyano-B12 (currently used in vitamin pills) and hydroxo-B12 (predominant form in the diet) in a population with nutritional vitamin B12 deficiency. Methods Fifty-one healthy Indian adults with baseline serum cobalamin < 200 pmol/L were supplied for 8 weeks with daily oral supplements of 3-µg cyano-B12 (n = 15), 3-µg hydroxo-B12 (n = 16), or a placebo (n = 20). Blood at baseline, and each following week, was examined for total cobalamin, holotranscobalamin, methylmalonic acid, and homocysteine. Results The study groups did not differ at baseline and were characterized by [median (range)] serum cobalamin [128 (68-191)

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B-vitamin interventions for women and children in low-income populations

Cited by 21 publications

References 27 publications

The relationship between dietary micronutrients intake and cognition test performance among school‐aged children in government‐owned primary schools in Kumasi metropolis, Ghana

The relationship between dietary micronutrients intake and cognition test performance among school‐aged children in government‐owned primary schools in Kumasi metropolis, Ghana

Vitamin B-12 and Cognition in Children

Effect of 8-week oral supplementation with 3-µg cyano-B12 or hydroxo-B12 in a vitamin B12-deficient population

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