B‐type natriuretic peptide levels at birth predict cardiac dysfunction in neonates

Moriichi, Akinori; Cho, Kazutoshi; Mizushima, Masato; Furuse, Yuta; Akimoto, Takuma; Yamada, Takashi; Minakami, Hisanori

doi:10.1111/j.1442-200x.2011.03500.x

Cited by 20 publications

(17 citation statements)

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“…In another study, Ainori Morichi et al explained that serum BNP level is useful for predicting cardiac dysfunction at the birth time. Also they found a relationship between Gestational Age and BNP serum level and as a result, observed an increased BNP serum level in "Small for Gestational Age" infants (27). It shows that an increase in prematurity frequency can decrease the production of surfactant and the lungs compliance.…”

Section: Discussionmentioning

confidence: 90%

Brain Natriuretic Peptide: A Predictor for Severity Respiratory Distress Syndrome in Newborns

et al. 2013

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Background:Respiratory distress syndrome (RDS) is considered as one of the most popular prematurity-related respiratory problems and among the most prominent reasons of deaths in preterm infants. Objectives: Brain Natriuretic Peptide (BNP) is the secret of the volume and pressure overload response of the vessels and decreases due to resistance as well as rises in systemic vessels and also in decline of pulmonary artery pressure. In the present paper, BNP is considered as a biomarker for prediction of RDS scoring. Materials and Methods: In this case, 65 preterm infants under 37 weeks with an Apgar score more than seven and 65 healthy term infants were chosen. All of them were controlled for three days in NICU and then divided into 4 groups based on the RDS scoring and intensity, as well as chest x-ray findings; normal, mild, moderate, and severe. Serum BNP of all the infants was measured through ELISA kit and a questionnaire was filled up for each infant based on his/her demographic information and clinical findings. The collected data were analyzed by SPSS software based on the independent statistical t-test, one-sided variance analysis and X2. P < 0.05 was considered as the significant. Results:The study results revealed a significant difference between the two groups regarding the pregnancy age, weight and type of delivery between cases and control groups (P ≥ 0.05); but there was no significant difference between BNP in cases and control groups (P ≤ 0.05). However, the comparison between the mean of pregnancy weight, pregnancy age, and BNP based on RDS frequency among the patients was significant (P ≥ 0.05). Conclusions:The results of this study demonstrated that serum BNP level correlates with increased RDS scoring. Therefore, it is possible to use BNP as the prediction marker for the progressive changes of RDS which occur in premature infants.

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Section: Discussionmentioning

confidence: 90%

Brain Natriuretic Peptide: A Predictor for Severity Respiratory Distress Syndrome in Newborns

et al. 2013

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“…9 High BNP levels in the umbilical cord blood and amniotic fluid are a predictive factor for cardiac dysfunction and hypotension soon after birth in singleton neonates. 10 The natriuretic peptide systems have been shown to be activated in monochorionic diamniotic (MD) twins with twinto-twin transfusion syndrome (TTTS), and they have an important role in the appearance of clinical manifestations. 11,12 Recently, a positive correlation between amniotic fluid levels of brain-type natriuretic peptide and recipient cardiomyopathy in TTTS was reported.…”

Section: Introductionmentioning

confidence: 99%

N-terminal pro-brain natriuretic peptide levels in monochorionic diamniotic twins with selective intrauterine growth restriction

et al. 2013

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“…This may indicate that perinatal asphyxia leads to a very early increase of natriuretic peptides, as it has its onset already during labor. This speculation of a rapid increase of BNP concentrations in perinatal asphyxia is supported by the study of Moriichi et al reporting elevated BNP levels in the amniotic fluid and in the umbilical cord blood of neonates with perinatal asphyxia (32).…”

Section: Discussionmentioning

confidence: 91%

Aminoterminal Pro-B-Type Natriuretic Peptide

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Wagner

et al. 2013

Pediatric Critical Care Medicine

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B‐type natriuretic peptide levels at birth predict cardiac dysfunction in neonates

Abstract: High UCB-BNP and AF-BNP levels predict neonatal cardiac dysfunction soon after birth.

Cited by 20 publications

References 19 publications

Brain Natriuretic Peptide: A Predictor for Severity Respiratory Distress Syndrome in Newborns

Brain Natriuretic Peptide: A Predictor for Severity Respiratory Distress Syndrome in Newborns

N-terminal pro-brain natriuretic peptide levels in monochorionic diamniotic twins with selective intrauterine growth restriction

Aminoterminal Pro-B-Type Natriuretic Peptide

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