B-Type Natriuretic Peptide in the Emergency Diagnosis of Critical Heart Disease in Children

Abstract

B-type natriuretic peptide levels were markedly elevated at presentation in the acute care setting for all patients in this cohort of children with newly diagnosed congenital or acquired heart disease. B-type natriuretic peptide levels from noncardiac patients were significantly lower, with no overlap to the cardiac disease group. B-type natriuretic peptide level can be useful as a diagnostic marker to aid in the recognition of pediatric critical heart disease in the acute care setting.

Brain natriuretic peptide: the reason of respiratory distress is heart disease or lung disease?

“…Many cardiac disease states (ventricular septal defect (VSD), patent ductus arteriosus (PDA), coarctation of aorta, cardiomyopathy…etc ) can mimic the more common illnesses of childhood, such as bronchiolitis, reactive airway disease and sepsis (1). Acute bronchiolitis, one of the most common disease of this group, is most commonly seen in children under two years of age.…”

“…Because of that a sensitive, reachable marker to aid in the recognition of heart disease and lung disease in children will be useful (1).…”

A clinical importance of natriuretic peptides in pediatric practice

“…В частности, в когортном иссле-довании медицинского центра США (англ. Children's Healthcare of Atlanta) выявили достоверное увеличение BNP в группе детей с кардиологической патологией (в том числе с ВПС) в сравнении с детьми без патологии сердца [24,25]. Другое исследование, опубликован-ное Law Y.M.…”

Aetiology, diagnosis and management of heart failure in infants and children

“…(36) ■ to discriminate serious from non-serious disease among children with newly diagnosed cardiac disease. (37) Also, BNP and NT-proBNP levels are higher in children with newly diagnosed heart failure or those with acute exacerbations of chronic heart failure; higher BNP levels predict poor prognosis; improved BNP levels suggest improved ventricular function; following complex heart surgery, BNP is predictive of heart failure and BNP might be helpful as a marker of anthracycline induced myocardial toxicity. (38)(39)(40)(41)(42)(43) Other studies…”