B-type natriuretic peptide in hypertensive crises: Diagnostic use in hypertensive urgencies and emergencies

Maraghi, S. El; Yahia, Hend; Heikal, Ayman; Ashraf, Mohamed

doi:10.1016/j.ejccm.2013.01.002

Cited by 7 publications

(9 citation statements)

References 29 publications

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“…Their report contrasts our finding of an AUC of 0.62 (P=0.059) for the composite of hypertensive emergency. Although NT-proBNP had an AUC of 0.89 in our patients with acute pulmonary edema, the study that reported an AUC of 0.96 did not include acute pulmonary edema or acute heart failure [7], and they excluded patients with eGFR<60 ml/min/1.73m 2 , a group that constituted nearly half of our patients with hypertensive emergency. However, a subgroup analysis of our cohort with eGFR> 60 ml/min/1.73m 2 revealed an AUC of 0.52 for NT-proBNP.…”

Section: Discussionmentioning

confidence: 95%

“…The presentation in patients with hypertensive emergency includes acute pulmonary edema, acute coronary syndrome, intracranial hemorrhage, ischemic stroke, hypertensive encephalopathy, aortic dissection, thrombotic microangiopathy, and malignant hypertension [3,4]. In addition to the distinctive clinical features of acute hypertension-mediated organ damage, biomarkers are increasingly used to identify patients with hypertensive emergency [6,7]. However, most hypertension guidelines recommend a context-dependent use of biomarkers (serum and imaging) [3,5].…”

Section: Introductionmentioning

confidence: 99%

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The Role of Cardiac Biomarkers in the Diagnosis of Hypertensive Emergency

Talle¹,

Doubell²,

Robbertse³

et al. 2023

Preprint

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

The Role of Cardiac Biomarkers in the Diagnosis of Hypertensive Emergency

Talle¹,

Doubell²,

Robbertse³

et al. 2023

Preprint

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“…Although previous studies in animal models and humans have demonstrated that corin, which plays a key role in the transformation of the natriuretic peptides, is critically involved in the regulation of salt-water balance, blood pressure, and cardiac function; the findings of clinical and experimental reports that assess corin and natriuretic peptide concentrations in hypertensive subjects remain controversial (13,14,26,33,35). Some studies have found decreased plasma natriuretic peptide and corin concentrations in response to elevated blood pressure, (13,26,33) whereas other studies have found increased plasma natriuretic peptide and corin concentrations (14,35). Peng et al (35) reported that serum corin levels were significantly higher in patients with hypertension than in normotensive controls.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have revealed that corin plays a key role in the transformation of pro-atrial natriuretic peptides (proANP) and pro-brain natriuretic peptides (proBNP) to active peptides (13). El Maraghi et al (14) found a positive correlation between BNP levels and the extent of end-organ damage in patients with HC; they concluded that BNP was a biomarker for assessing the extent of heart and brain damage in patients with HE. We hypothesized that serum soluble corin levels differed between patients with HU and patients with HE.…”

Section: Introductionmentioning

confidence: 99%

Low serum corin levels predict end-organ damage in patients with hypertensive crisis

Yavuz

Söğüt

Çolak

et al. 2021

The Anatolian Journal of Cardiology

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Objective: The study aimed to investigate the predictive power of serum corin levels for distinguishing between hypertensive urgency (HU) and hypertensive emergency (HE) in patients with hypertensive crisis (HC) admitted to the emergency department. Methods: A total of 120 consecutive consenting adult patients diagnosed with HC and 55 age-and sex-matched healthy controls were enrolled. Blood pressure measurements [(systolic, diastolic, and mean arterial pressure (MAP)] and the evidence of end-organ damage at the first admission were recorded. Patients with HC were classified as patients with HE or HU according to the presence or absence of acute end-organ damage. Serum corin levels were compared between the 2 groups. Results: The mean serum corin level was significantly lower in the HC group than in the control group; it was also lower in the HE group than in the HU group (p<0.001 for all). In the HE group, clinical features associated with end-organ damage included ST-elevation myocardial infarction (n=28, 46.7%), hemorrhagic stroke (n=11, 18.3%), ischemic stroke (n=11, 18.3%), and non-ST-elevation myocardial infarction (n=10, 16.7%). The receiving operator characteristic (ROC) analysis identified a serum corin cutoff value of 45 pg/mL for distinguishing patients with HE from patients with HU with 98.3% sensitivity and 95% specificity. Conclusion: Our findings suggest that serum corin levels play an important role in regulating blood pressure and are involved in the pathogenesis of HC. Low serum corin levels may predict end-organ damage and serve as a guide for diagnostic decision making in patients with HC.

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“…1). The possible reason for elevated B-type NP include: comorbid heart failure (HFpEF), chronic kidney disease, central nervous system malignancy itself, and/or hypertensive encephalopathy [16][17][18][19].…”

Section: Discussionmentioning

confidence: 99%

Difficult-to-control secondary hypertension in a patient with history of glioblastoma, and cerebral edema — a case study

Placek

Sołtysiak

Drozdowski

et al. 2021

Arterial Hypertension

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A 75-year-old female patient with uncontrolled high blood pressure, a history of hypertension secondary to chronic kidney disease, after unilateral nephrectomy due to cancer (clear cell renal cell carcinoma), remaining renal artery stenosis, all of which superimposed on long-lasting essential hypertension, and a suspicion of central nervous system (CNS) glioblastoma, was admitted to our Clinic after a convulsive episode. Blood pressure (BP) at admission was 254/98 mm Hg and the heart rate 38/min. Upon physical examination a residual left hemiparesis and left sided ataxia was evident. Standard electrocardiography and heart ultrasonography showed left ventricular (LV) hypertrophy and the impaired LV relaxation. Laboratory tests were consistent with the diagnosis of CKD; additionally, microcytic anemia and substantially elevated levels of NT-pro-BNP were documented (see Tab. 1).24-hour blood pressure monitoring showed mean 24-h systolic BP at 204 mm Hg and diastolic BP at 83 mm Hg (range from 156/71 to 239/94 mm Hg).

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B-type natriuretic peptide in hypertensive crises: Diagnostic use in hypertensive urgencies and emergencies

Cited by 7 publications

References 29 publications

The Role of Cardiac Biomarkers in the Diagnosis of Hypertensive Emergency

The Role of Cardiac Biomarkers in the Diagnosis of Hypertensive Emergency

Low serum corin levels predict end-organ damage in patients with hypertensive crisis

Difficult-to-control secondary hypertension in a patient with history of glioblastoma, and cerebral edema — a case study

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