B-type natriuretic peptide concentrations in contemporary Eisenmenger syndrome patients: predictive value and response to disease targeting therapy

Abstract

BNP concentrations predict outcome in contemporary Eisenmenger patients. Increases in BNP concentrations over time are also of prognostic significance. In addition, disease targeting therapies may help to reduce BNP concentrations in this population, while treatment-naïve patients have static or rising BNP concentrations.

The challenge of managing pulmonary arterial hypertension in adults with congenital heart disease

“…In a very recent study based on data of 181 ES patients, a composite echocardiographic score was also highly predictive of clinical outcome [35]. Another very recent study demonstrated the predictive value of BNP in ES [36].…”

Treatment of Terminal Heart Failure in Grown Up Congenital Heart Disease.

“…Drugi pokazatelj na koji bismo se mogli osloniti, BNP, potencijalno može biti iznimno vrijedan jer se pokazalo da predviđa iznenadnu srčanu smrt i ventrikularne poremećaje ritma čak i u onih bolesnika s PS-BO-om koji nemaju zatajivanje srca. Osim toga, pokazalo se da je povećanje koncentracije BNP-a tijekom praćenja dobar pretkazatelj smrtnosti 36, 37 . Stoga je preporučljivo u praćenju takvih bolesnika redovito i uzastopno testirati funkcijski kapacitet te pratiti BNP.…”

Almanac 2012: Congenital heart disease. The national society journals present selected research that has driven recent advances in clinical cardiology

“…49 A study of patients with Eisenmenger syndrome (n=181, age 36.9 ± 12.1 years, 31% with Down's syndrome), in whom B-type natriuretic peptide (BNP) concentrations were measured as part of routine clinical care, found that they predicted outcome. 50 In addition, the authors speculated that disease-targeting treatments may help to reduce BNP concentrations in this population, while treatment-naive patients have static or rising BNP concentrations. This topic was discussed in more detail in an editorial by D'Alto.…”