B-type natriuretic peptide as a predictor of ischemia/reperfusion injury immediately after myocardial reperfusion in patients with ST-segment elevation acute myocardial infarction

Arakawa, Kentaro; Himeno, Hideo; Kirigaya, Jin; Otomo, Fumie; Matsushita, Kensuke; Nakahashi, Hidefumi; Shimizu, Satoru; Nitta, Manabu; Takamizawa, Tetsu; Yano, Hideto; Endo, Mitsuaki; Kusumoto, Masahiko; Kimura, Kazuo; Umemura, Satoshi

doi:10.1177/2048872615568964

Cited by 9 publications

(7 citation statements)

References 41 publications

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“…This will further aggravate the reperfusion of ischaemic myocardium at the infarct site. BNP has been shown to be an independent risk factor for IR injury in ST-segment elevation AMI patients 39. Studies have shown that the increased secretion of BNP during myocardial ischaemia is mainly regulated by the PI3K/Akt/p70s6k signalling pathway, which has a protective effect on the myocardium 40.…”

Section: Discussionmentioning

confidence: 99%

Association of platelet-to-lymphocyte count ratio with myocardial reperfusion and major adverse events in patients with acute myocardial infarction: a two-centre retrospective cohort study

et al. 2019

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ObjectiveInsufficient myocardial reperfusion for patients with acute myocardial infarction (AMI) during primary percutaneous coronary intervention (PPCI) has a great influence on prognosis. The aim of this study was to investigate the association of the platelet-to-lymphocyte ratio (PLR) with myocardial reperfusion and in-hospital major adverse cardiac events (MACEs) in patients with AMI undergoing PPCI.DesignRetrospective cohort study.SettingPatients and researchers from two tertiary hospitals.ParticipantsA total of 445 consecutive AMI patients who underwent PPCI between January 2015 and December 2017 were enrolled. Patients were divided into two groups based on the PLR value: patients with PLR values in the third tertile were defined as the high-PLR group (n=150), and those in the lower two tertiles were defined as the low-PLR group (n=295). Explicit criteria for inclusion and exclusion were applied.InterventionsNo interventions.Primary and secondary outcome measuresPrimary outcome measures were defined as cardiovascular death, reinfarction or target vessel revascularisation. Secondary outcome measures were defined as stroke, non-lethal myocardial infarction, ventricular tachycardia/ventricular fibrillation and in-hospital mortality.ResultsThe high-PLR group had insufficient myocardial perfusion (23% vs 13%, p=0.003), greater postprocedural thrombolysis in myocardial infarction flow grade (0–2) (17% vs 10%, p=0.037), greater myocardial blush grade (0–1) (11% vs 4%, p=0.007) and higher B-type natriuretic peptide (BNP) (614±600 vs 316±429, p<0.001) compared with the low-PLR group. Multivariate logistic regression analysis indicated that the independent risk factors for impaired myocardial perfusion were high PLR (OR 1.256, 95% CI 1.003 to 1.579, p=0.056) and high BNP (OR 1.328, 95% CI 1.056 to 1.670, p=0.015). The high-PLR group had significantly more MACEs (43% vs 32%, p=0.029).ConclusionsThis study suggested that high PLR and BNP were independent risk factors for insufficient myocardial reperfusion in patients with AMI. Higher PLR was related to advanced heart failure and in-hospital MACEs in patients with AMI undergoing PPCI.

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Section: Discussionmentioning

confidence: 99%

Association of platelet-to-lymphocyte count ratio with myocardial reperfusion and major adverse events in patients with acute myocardial infarction: a two-centre retrospective cohort study

et al. 2019

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“…However, the GRACE risk score is excessively complicated with respect to predicting early severity, and requires serial or multiple measurements to determine the severity. Serum biomarkers, such as NT-proBNP and high-sensitivity CRP (hs-CRP), are widely used to identify ischaemia-reperfusion injury and prognosis after reperfusion in patients with STEMI, assisting in the estimation of infarct size, microvascular obstruction, and left-ventricular remodelling, and in the stratification of risk in patients with AMI 22 , 23 . Both the peak CK-MB and peak Tn-I levels have been shown to be independently associated with in-hospital mortality 24 .…”

Section: Discussionmentioning

confidence: 99%

Usefulness of the delta neutrophil index to predict 30-day mortality in patients with ST segment elevation myocardial infarction

Kong

Kim

Park

et al. 2017

Sci Rep

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This study aimed to evaluate the association between the delta neutrophil index (DNI), which reflects immature granulocytes, and the severity of ST-elevation myocardial infarction (STEMI), as well as to determine the significance of the DNI as a prognostic marker for early mortality and other clinical outcomes in patients with STEMI who underwent reperfusion. This retrospective, observational cohort study was conducted using patients prospectively integrated in a critical pathway program for STEMI. We included 842 patients diagnosed with STEMI who underwent primary percutaneous coronary intervention (pPCI). Higher DNI values at time-I (within 2 h of pPCI; hazard ratio [HR], 1.075; 95% confidence interval [CI]: 1.046–1.108; p < 0.001) and time-24 (24 h after admission; HR, 1.066; 95% CI: 1.045–1.086; p < 0.001) were significant independent risk factors for 30-day mortality. Specifically, DNI values >2.5% at time-I (HR, 13.643; 95% CI: 8.13–22.897; p < 0.001) and > 2.9% at time-24 (HR, 12.752; 95% CI: 7.308–22.252; p < 0.001) associated with increased risks of 30-day mortality. In conclusion, an increased DNI value, which reflects the proportion of circulating immature granulocytes in the blood, was found to be an independent predictor of 30-day mortality and poor clinical outcomes in patients with acute STEMI post-pPCI.

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“…N-terminal pro-B-type natriuretic peptide (NT-proBNP) measured in the acute and chronic phase after acute myocardial infarction (AMI) predicts the occurrence of left ventricular (LV) dysfunction, heart failure and death. [1][2][3][4] Enhanced myocardial wall stress is the most important trigger of NT-proBNP release. 5 Consequently, high NT-proBNP concentrations indicate cardiac pressure overload.…”

Section: Introductionmentioning

confidence: 99%

N-terminal pro-B-type natriuretic peptide is associated with aortic stiffness in patients presenting with acute myocardial infarction

Feistritzer

Reinstadler

Klug

et al. 2016

European Heart Journal: Acute Cardiovascular Care

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B-type natriuretic peptide as a predictor of ischemia/reperfusion injury immediately after myocardial reperfusion in patients with ST-segment elevation acute myocardial infarction

Cited by 9 publications

References 41 publications

Association of platelet-to-lymphocyte count ratio with myocardial reperfusion and major adverse events in patients with acute myocardial infarction: a two-centre retrospective cohort study

Association of platelet-to-lymphocyte count ratio with myocardial reperfusion and major adverse events in patients with acute myocardial infarction: a two-centre retrospective cohort study

Usefulness of the delta neutrophil index to predict 30-day mortality in patients with ST segment elevation myocardial infarction

N-terminal pro-B-type natriuretic peptide is associated with aortic stiffness in patients presenting with acute myocardial infarction

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