B-type natriuretic peptide and N-terminal pro-BNP in the acute phase of Kawasaki disease

Iwashima, Satoru; Ishikawa, Takamichi

doi:10.1007/s12519-013-0402-8

Cited by 20 publications

(24 citation statements)

References 27 publications

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“…They found that diastolic dysfunction occurs during the acute phase of the disease and BNP levels correlated well with the presence of significant diastolic dysfunction[32]. Similarly, Iwashima et al[33] have demonstrated the utility of BNP in identifying non-responders. They demonstrated that high level of NT-pro BNP in acute phase KD was associated with systemic inflammatory responses, elevated CRP, and increased vascular permeability.…”

Section: B-type Natriuretic Peptide and N-terminal Segment Of Pro-b-tmentioning

confidence: 99%

“…They demonstrated that high level of NT-pro BNP in acute phase KD was associated with systemic inflammatory responses, elevated CRP, and increased vascular permeability. This level was particularly higher in immunoglobulin (IVIg) non-responders compared to responders (1689.3 ± 1168.8 pg/dL vs 844.4 ± 1276.3 pg/dL, P < 0.001)[33]. …”

Section: B-type Natriuretic Peptide and N-terminal Segment Of Pro-b-tmentioning

confidence: 99%

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Cardiac biomarkers in pediatric heart disease: A state of art review

Fernandes¹,

Maher²,

Deshpande³

2016

WJC

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Every year there are more than 11000 hospitalizations related to heart failure in children resulting in significant morbidity and mortality. Over the last two decades, our understanding, diagnosis and management of pediatric heart failure is evolving but our ability to prognosticate outcomes in pediatric heart acute heart failure is extremely limited due to lack of data. In adult heart failure patients, the role of cardiac biomarkers has exponentially increased over the last two decades. Current guidelines for management of heart failure emphasize the role of cardiac biomarkers in diagnosis, management and prognostication of heart failure. It is also noteworthy that these biomarkers reflect important biological processes that also open up the possibility of therapeutic targets. There is however, a significant gap present in the pediatric population with regards to biomarkers in pediatric heart failure. Here, we seek to review available data regarding cardiac biomarkers in the pediatric population and also explore some of the emerging biomarkers from adult literature that may be pertinent to pediatric heart failure.

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Section: B-type Natriuretic Peptide and N-terminal Segment Of Pro-b-tmentioning

confidence: 99%

Section: B-type Natriuretic Peptide and N-terminal Segment Of Pro-b-tmentioning

confidence: 99%

Cardiac biomarkers in pediatric heart disease: A state of art review

Fernandes¹,

Maher²,

Deshpande³

2016

WJC

View full text Add to dashboard Cite

show abstract

“…Other researchers have obtained similar results , but those studies involved only small study samples. The study by Iwashima and Ishikawa involved only 91 KD patients, including 14 who failed to respond to the initial IVIG infusion. In addition, the results suggested that NT‐proBNP levels in KD‐nonresponsive patients were higher, but the authors failed to give a specific cutoff value for predicting the IVIG response.…”

Section: Discussionmentioning

confidence: 99%

A Comprehensive Assessment of the Value of Laboratory Indices in Diagnosing Kawasaki Disease

Shao

Shang

et al. 2015

Arthritis & Rheumatology

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Objective Kawasaki disease (KD) is the primary cause of heart disease among children, but because its clinical symptoms are nonspecific, it is difficult to diagnose. The purpose of this study was to evaluate laboratory indices for possible use in the early diagnosis of KD and to determine which indices are predictive of a response to intravenous immunoglobulin (IVIG) and can be used to monitor the effects of treatment. Methods Three hundred thirty KD patients, 330 age‐matched children with KD‐like febrile disease, and 330 age‐matched healthy children (controls) were enrolled in this prospective study. Levels of N‐terminal pro–brain natriuretic peptide (NT‐proBNP), erythrocyte sedimentation rate (ESR), C‐reactive protein (CRP), and cytokines were determined in all study subjects. Results In the derivation cohort, 181 patients in the KD group were compared with 181 patients in the KD‐like febrile group. The following indices were found to be useful in the diagnosis of KD: NT‐proBNP (area under the curve [AUC] 0.923), ESR (AUC 0.909), CRP (AUC 0.834), and interleukin‐6 (IL‐6; AUC 0.678). The diagnostic efficiency of each index demonstrated in the derivation cohort was repeated in the 149 KD patients in the validation cohort. There were significant differences in NT‐proBNP levels between IVIG‐responsive KD patients (n = 270) and IVIG‐nonresponsive KD patients (n = 60), with higher NT‐proBNP levels in IVIG‐nonresponsive KD patients. The NT‐proBNP level can effectively distinguish IVIG‐responsive KD patients from IVIG‐nonresponsive patients, and its AUC was 0.73. There were also significant differences in the NT‐proBNP levels before and after treatment, with a significant decline after treatment. Conclusion Serum levels of NT‐proBNP can be used in the diagnosis of KD, the prediction of a patient's sensitivity to IVIG treatment, and the monitoring of the effects of IVIG treatment, but more attention must be paid to the scope of its application.

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“…Recent studies also report that the level of blood NT-proBNP is of great significance in diagnosing incomplete Kawasaki disease at an early time [5,6]. Secreted NT-proBNP is increased in Kawasaki disease and incomplete Kawasaki disease because of the partial inflammatory damages of cardiac muscle, and also increased synthesis in the ventricular myocytes stimulated by some inflammatory factors [7,8].…”

Section: Discussionmentioning

confidence: 99%

Blood N-terminal pro-brain natriuretic peptide and interleukin-17 for distinguishing incomplete Kawasaki disease from infectious diseases

Wu¹,

Chen²,

Zhong³

et al. 2015

Indian Pediatr

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Objective: To explore the diagnostic value of blood N-terminal pro-brain natriuretic peptide (NT-proBNP) and interleukin-17(IL-17) for incomplete Kawasaki disease. Methods:Patients with Kawasaki disease, Incomplete Kawasaki disease and unclear infectious fever were included in this retrospective study. Their clinical features, and laboratory test results of blood NT-proBNP and IL-17 were collected and compared.Results: 766 patients with complete clinical information were recruited, consisting of 291 cases of Kawasaki disease, 74 cases of incomplete Kawasaki disease, and 401 cases of unclear infectious diseases. When the consistency with indicator 2 and 3 in Kawasaki disease diagnosis criteria was assessed with blood IL-17 ≥11.55 pg/mL and blood NT-proBNP ≥ 225.5 pg/dL as the criteria, the sensitivity and specificity for distinguishing incomplete Kawasaki disease and infectious diseases reached 86.5% and 94.8%, respectively. When we chose the consistency with indicator 1 and 2 in Kawasaki disease diagnosis criteria, the appearance of decrustation and/or the BCG erythema, blood IL-17 ≥11.55 pg/mL and blood NT-Pro BNP ≥225.5 pg/dL as the criteria, the sensitivity and specificity for distinguishing incomplete Kawasaki disease and infectious diseases was 43.2% and 100%, respectively. Conclusion:Blood NT-proBNP and IL-17 are useful laboratory indicators for distinguishing incomplete Kawasaki disease and infectious diseases at the early stage.

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B-type natriuretic peptide and N-terminal pro-BNP in the acute phase of Kawasaki disease

Abstract: A high level of NT-pro BNP in acute phase KD is associated with systemic inflammatory responses and increased vascular permeability. The NT-pro BNP level is a useful marker to identify potential non-responders to IVIG among KD patients.

Cited by 20 publications

References 27 publications

Cardiac biomarkers in pediatric heart disease: A state of art review

Cardiac biomarkers in pediatric heart disease: A state of art review

A Comprehensive Assessment of the Value of Laboratory Indices in Diagnosing Kawasaki Disease

Blood N-terminal pro-brain natriuretic peptide and interleukin-17 for distinguishing incomplete Kawasaki disease from infectious diseases

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