B-type natriuretic peptide and acute heart failure: Fluid homeostasis, biomarker and therapeutics

Torres-Courchoud, I.; Chen, H.H.

doi:10.1016/j.rceng.2016.01.005

Cited by 2 publications

(1 citation statement)

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“…In humans, the blood concentration of BNP is increased in patients with cardiac diseases due to mechanical stimuli (de Bold et al 1996 ). Therefore, the blood concentration of the natriuretic peptide and its N-terminal fragment (NT-pro-BNP) is used in human medicine as a diagnostic tool in patients presenting with acute dyspnoea for the identification of heart diseases and differentiation from primary diseases of the respiratory system (Torres-Courchoud and Chen 2016 ). It can also be used as an efficient prognostic marker for the risk of future cardiac events and mortality (Santaguida et al 2014 ).…”

Section: Introductionmentioning

confidence: 99%

The B-type natriuretic peptide of the Congo and Timneh grey parrot

Hennig

Mohr²,

Fehr

et al. 2021

Vet Res Commun

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In captivity, cardiovascular diseases are common in grey parrots. The diagnosis of these diseases in living birds is difficult, and new diagnostic possibilities would be desirable. The heart is an important endocrine organ in which cardiomyocytes synthetise B-type natriuretic peptide (BNP) and release it into the bloodstream. This hormone has a significant role in cardiovascular and body fluid regulation. The blood concentration of BNP is used in human medicine and small animal medicine as a diagnostic tool in the identification of heart diseases and as a prognostic marker for the risk of mortality. The nucleotide and amino acid sequence of BNP was described in Congo (n = 4) and Timneh (n = 3) grey parrots by PCR after RNA isolation from the atria and ventricles. The results showed a high similarity between the nucleotide sequences of the grey parrots’ BNP and the already known sequence of this hormone in chickens. The amino acid sequence of the mature peptide region is consistent in these three species. BNP plasma concentration could be a possible blood parameter for identifying clinically manifest cardiovascular diseases in grey parrots as it is in other species.

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Section: Introductionmentioning

confidence: 99%