The Correlation of Biological Activity of Plant Growth Regulators and Chloromycetin Derivatives with Hammett Constants and Partition Coefficients

Structure-based design of nonpeptide inhibitors specific for the human immunodeficiency virus 1 protease.

“…Once an active compound is found, derivatives are made and tested. The results of such studies guide subsequent development, often assisted by structure-activity relationships (2). Alternatively, it has been possible to use knowledge of specific enzyme mechanisms or cellular processes to provide starting points for drug discovery (3)(4)(5).…”

Structure-activity Relationship of Herbicidal 2,3-Dicyano-5-Substituted Pyrazines

“…The steric bulk of the para-substituent seems to show undesirable effects on the potency of the activity at the ultimate site of herbicidal action. This situation is similar to the fact that the herbicidal activity of N-chloroacetyl-N-phenyl glycinates 19 ) and the auxin activity of phenoxyacetic acids 20 ) disappear when large substituent groups are introduced in the paraposition.…”

Toshio Fujita, 1929–2017

“…His collaboration with Prof. Corwin Hansch resulted in the publication of seminal papers on the establishment of quantitative analysis of structure-activity relationships of biologically active compounds (quantitative structure-activity relationship, QSAR). 1,2) After his promotion to associate professor of the Pesticide Chemistry Lab of Department of Agricultural Chemistry at Kyoto University in 1965, he expanded his research activities to include quantitative analysis of the structure-activity relationships of a number of various agrochemicals using physicochemical parameters related to free energy. In 1981, he succeeded Prof. Nakajima as the professor of the Pesticide Chemistry Laboratory, which was renamed the Bioregulation Chemistry Laboratory, and further expanded his work to include QSAR and molecular design of a broader range of biologically active compounds, including pharmaceuticals.…”