<b>Sydney Breast Imaging Accuracy Study:</b> Comparative Sensitivity and  Specificity of Mammography and Sonography in Young Women with Symptoms

Houssami, Nehmat; Irwig, Les; Simpson, Judy M.; McKessar, Merran; Blome, Steven; Noakes, Jennie

doi:10.2214/ajr.180.4.1800935

Cited by 162 publications

(99 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a study published in American journal of Roentgenology in 2003, first of its kind by N. Houssami from Sydney, Australia, show that sonography of breast is an accurate imaging test in women 45 years or younger who present with breast symptoms and may be an appropriate investigation [23]. Thus, in Indian scenario with younger age of breast cancer incidence, sonographic evaluation of young patients with breast symptoms is appropriate.…”

Section: Excised Specimenmentioning

confidence: 99%

Preoperative ultrasound guided needle localisation for non-palpable breast lesions

et al. 2010

View full text Add to dashboard Cite

show abstract

Section: Excised Specimenmentioning

confidence: 99%

Preoperative ultrasound guided needle localisation for non-palpable breast lesions

et al. 2010

View full text Add to dashboard Cite

show abstract

“…As early-onset breast cancer in itself is associated with a poorer prognosis (Sidoni et al, 2003), it may be advantageous to initiate breast cancer screening among multiparous women with the IGF1-19/-19 genotype at an earlier age. Alternative screening methods may be needed in this age group as mammography shows poor sensitivity in young women (Houssami et al, 2003). Conversely, among patients with fewer than two children, the IGF1-19/-19 genotype was associated with a later age of breast cancer onset, and these women may initiate screening at a later age.…”

Section: Igf1-19/-mentioning

confidence: 99%

Absence of the common Insulin-like growth factor-1 19-repeat allele is associated with early age at breast cancer diagnosis in multiparous women

et al. 2007

View full text Add to dashboard Cite

Multiparity decreases the risk of breast cancer in white women, whereas it is a risk factor in black women o50 years. Early-onset breast cancer (o50 years) has been associated with high insulin-like growth factor-1 (IGF-1) levels. Absence of the common IGF1 19 cytosine-adenine (CA)-repeat allele (IGF1-19/-19) inverts the effect of several non-genetic factors on breast cancer risk but the interaction between IGF1-19/-19 and multiparity on breast cancer risk is unknown. As IGF1-19/-19, multiparity and early-onset breast cancer are more common in black than in white women, we aimed to study whether multiparity combined with IGF1-19/-19 increases the risk of early-onset breast cancer. Four hundred and three breast cancer patients diagnosed in Lund, Sweden, at age 25 -99 years were genotyped for the IGF1 CA-repeat length using fragment analysis. Overall, 12.9% carried the IGF1-19/-19 genotype. There was a highly significant interaction between multiparity and IGF1-19/-19 on age at breast cancer diagnosis (P ¼ 0.007). Among IGF1-19/-19 patients, multiparity was associated with a 9.2 year earlier age at diagnosis compared with uniparity or nulliparity (P ¼ 0. Breast cancer is the most common malignancy in women worldwide (Parkin et al, 2001(Parkin et al, , 2002. Approximately 10% of women living in Sweden will develop the disease during their lifetime. The median age at breast cancer diagnosis in women in Sweden is 60 years; approximately 4% of women are 40 years or younger at diagnosis (data from the Swedish Cancer Registry). The prognosis is often poorer in younger than in older women (Sidoni et al, 2003) in terms of overall survival and relapse (Han et al, 2004), partly because young women do not benefit from breast cancer screening and early-onset breast cancers are usually detected clinically at a more advanced stage. In Lund, Sweden, mammography screening is initiated at age 45 years and is performed every 18 months until the age of 74 years. As of today, no tests are routinely performed to identify the subgroup of women who do not belong to high-risk breast cancer families (eg BRCA1 families) but who would nevertheless benefit from breast cancer screening at an earlier age owing to an increased risk for early-onset breast cancer.Breast cancer risk is determined by genetic factors and nongenetic factors, for example, reproductive factors (Beral and Reeves, 1993;Kelsey et al, 1993). An increased age at first full-term pregnancy and low parity have been associated with an increased risk of developing breast cancer in the developed world (Kelsey et al, 1993). In the short term, a first full-term pregnancy increases the risk of breast cancer (Beral and Reeves, 1993). Each subsequent live-birth reportedly decreases the risk of breast cancer by 30% and after three full-term pregnancies, the short-term risk of developing breast cancer is similar to the risk of nulliparous women (McCredie et al, 1998). In the long-term, a full-term pregnancy confers a decreased risk of developing breast cancer (McCredie et al, 1998) and ...

show abstract

“…Many published studies have confirmed that the sensitivity of mammography increases with age. 9,10 The sensitivity of mammography may be decreased further in women who carry a deleterious mutation in BRCA1 or BRCA2; pilot studies evaluating mammography in BRCA1 and BRCA2 carriers have found a high rate of false-negative results. 6,11,12 This may be attributable both to increased breast density in young women and to tumor phenotype, including features such as pushing margins, which may contribute to a smooth appearance rather than a spiculated appearance of a mass on mammography.…”

mentioning

confidence: 99%

Breast magnetic resonance image screening and ductal lavage in women at high genetic risk for breast carcinoma

Hartman

Daniel

Kurian

et al. 2004

Cancer

View full text Add to dashboard Cite

Surface tension and viscosity are the important properties of liquid binders affecting wet granulation processes. They could be used to control solids flow pattern and relative motion of particles for controlling wetting, granule growth, consolidation, and breakage. This study aims to investigate experimentally the impacts of the two properties with a conical high shear granulator. The results show significant effects of viscosity and surface tension on solids flow pattern and relative motion of particles. The relative importance of the two parameters, the surface tension and the viscosity, are found to vary with the axial and radial positions in the granulator. For example, the viscosity force decreases with an increase in the bed height in the axial direction (vertical plane). The viscosity force between particles coated with PEG4000 solution is in mN order, whereas that between particles coated with ethanol and water is in μN order. © 2009 American Institute of Chemical Engineers AIChE J, 2009

show abstract

Sydney Breast Imaging Accuracy Study: Comparative Sensitivity and Specificity of Mammography and Sonography in Young Women with Symptoms

Abstract: These data show that sonography is the more accurate imaging test in women 45 years old or younger who present with breast symptoms and may be an appropriate initial imaging examination.

Cited by 162 publications

References 12 publications

Preoperative ultrasound guided needle localisation for non-palpable breast lesions

Preoperative ultrasound guided needle localisation for non-palpable breast lesions

Absence of the common Insulin-like growth factor-1 19-repeat allele is associated with early age at breast cancer diagnosis in multiparous women

Breast magnetic resonance image screening and ductal lavage in women at high genetic risk for breast carcinoma

Contact Info

Product

Resources

About