<b>Solid Variant of Aneurysmal Bone Cysts in Long Tubular Bones:</b> Giant Cell Reparative Granuloma

Ilaslan, Hakan; Sundaram, Murali; Unni, K. Krishnan

doi:10.2214/ajr.180.6.1801681

Cited by 76 publications

(46 citation statements)

References 23 publications

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“…32 It has been suggested central giant cell reparative granuloma is a solid variant of aneurysmal bone cyst. 33,34 In this respect, it is noteworthy that the majority of aneurysmal bone cysts examined failed to express p63 suggesting they may be related tumors. However, the presence of p63 expression in some cases of aneurysmal bone cyst is as yet unexplained.…”

Section: Discussionmentioning

confidence: 89%

Giant cell tumor of bone express p63

Dickson

Wunder

et al. 2008

Modern Pathology

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p63 contributes to skeletal development and tumor formation; however, little is known regarding its activity in the context of bone and soft tissue neoplasms. The purpose of this study was to investigate p63 expression in giant cell tumor of bone and to determine whether it can be used to discriminate between other giant cell-rich tumors. Seventeen cases of giant cell tumor of bone were examined to determine the cell type expressing p63 and identify the isoforms present. Total RNA or cell protein was extracted from mononuclear-or giant cellenriched fractions or intact giant cell tumor of bone and examined by RT-PCR or western blot, respectively. Immunohistochemistry was used to evaluate p63 expression in paraffin embedded sections of giant cell tumor of bone and in tumors containing multinucleated giant cells, including: giant cell tumor of tendon sheath, pigmented villonodular synovitis, aneurysmal bone cyst, chondroblastoma, and central giant cell granuloma. The mononuclear cell component in all cases of giant cell tumor of bone was found to express all forms of TAp63 (a, b, and c), whereas only low levels of the TAp63 a and b isoforms were detected in multinucleated cells; DNp63 was not detected in these tumors. Western blot analysis identified p63 protein as being predominately localized to mononuclear cells compared to giant cells. This was confirmed by immunohistochemical staining of paraffin-embedded tumor sections, with expression identified in all cases of giant cell tumor of bone. Only a proportion of cases of aneurysmal bone cyst and chondroblastoma showed p63 immunoreactivity whereas it was not detected in central giant cell granuloma, giant cell tumor of tendon sheath, or pigmented villonodular synovitis. The differential expression of p63 in giant cell tumor of bone and central giant cell granuloma suggest that these two tumors may have a different pathogenesis. Moreover, p63 may be a useful biomarker to differentiate giant cell tumor of bone from central giant cell granuloma and other giant cell-rich tumors, such as giant cell tumor of tendon sheath and pigmented villonodular synovitis.

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Section: Discussionmentioning

confidence: 89%

Giant cell tumor of bone express p63

Dickson

Wunder

et al. 2008

Modern Pathology

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“…Histologically these lesions may be mistaken for low-grade osteosarcoma [1,15]. Solid aneurysmal bone cysts have a varied radiographic appearance, occur more frequently on the metaphyseal and diaphyseal portions of long bones, and on MR images show solid and cystic elements in an expansive osteolytic lesion [8]. Brodie's abscess is one type of subacute osteomyelitis.…”

Section: Discussion and Treatmentmentioning

confidence: 99%

Femur Mass in a 43-Year-Old Woman

Epelboym

Desai

Garcı́a

et al. 2012

Clinical Orthopaedics &Amp; Related Research

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A 43-year-old woman was seen in consultation for a lesion in her left distal femur. One year earlier she began experiencing pain in her left knee after a fall. The pain was worse at night and awakened the patient from sleep. The patient had a 26-year smoking history. Her family history was significant for a father who had an unspecified sarcoma of the leg. Physical examination showed full ROM in the extremities, with no lymphadenopathy, palpable masses, or reproducible tenderness. Complete blood count, chemistries, and erythrocyte sedimentation rate were normal whereas her C-reactive protein was slightly elevated at 5.3 mg/L (reference, 0-4.9 mg/L).The patient underwent plain radiography ( Fig.

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“…to occur in the face and spine, femur and tibia, and short tubular bones of the hands and feet [1,2,5,7]. When occurring in the mandible, maxilla, hands, or feet, S-ABC may be referred to as "giant cell reparative granuloma" [4,5,7].…”

mentioning

confidence: 99%

“…When occurring in the mandible, maxilla, hands, or feet, S-ABC may be referred to as "giant cell reparative granuloma" [4,5,7].…”

mentioning

confidence: 99%