B-scan ultrasound imaging of thermal coagulation in bovine liver: frequency shift attenuation mapping

Bevan, Peter D.; Sherar, Michael D.

doi:10.1016/s0301-5629(01)00380-5

Cited by 48 publications

(22 citation statements)

References 13 publications

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“…Magnetic resonance imaging (MRI) [9,26,30], US [1,17] and computed tomography (CT) [2,8] have all been investigated to monitor thermal therapy, however these methods are either expensive, lack accurate real-time monitoring, have poor contrast or temporal resolution. Transmission ultrasound is an alternative to previously studied methods of monitoring thermal therapy.…”

Section: Introductionmentioning

confidence: 99%

An investigation of the use of transmission ultrasound to measure acoustic attenuation changes in thermal therapy

Parmar

Kolios

2006

Med Bio Eng Comput

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The potential of using a commercial ultrasound transmission imaging system to quantitatively monitor tissue attenuation changes after thermal therapy was investigated. The ultrasound transmission imaging system used, the AcoustoCam (Imperium Inc., MD) allows ultrasonic images to be captured using principles similar to that of a CCD-type camera that collects light. Ultrasound energy is focused onto a piezoelectric array by an acoustic lens system, creating a gray scale acoustic image. In this work, the pixel values from the acoustic images were assigned acoustic attenuation values by imaging polyacrylamide phantoms of varying known attenuation. After the calibration procedure, data from heated polyacrylamide/bovine serum albumin (BSA) based tissue-mimicking (TM) phantoms and porcine livers were acquired. Samples were heated in water at temperatures of 35, 45, 55, 65, and 75 degrees C for 1 h. Regions of interest were chosen in the images and acoustic attenuation values before and after heating were compared. An increase in ultrasound attenuation was found in phantoms containing BSA and in porcine liver. In the presence of BSA, attenuation in the TM phantom increased by a factor of 1.5, while without BSA no significant changes were observed. The attenuation of the porcine liver increased by up to a factor of 2.4, consistent with previously reported studies. The study demonstrates the feasibility of using a quantitative ultrasound transmission imaging system for monitoring thermal therapy.

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Section: Introductionmentioning

confidence: 99%

An investigation of the use of transmission ultrasound to measure acoustic attenuation changes in thermal therapy

Parmar

Kolios

2006

Med Bio Eng Comput

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“…These observations led the authors to investigate whether imaging of the ultrasound attenuation coefficient could be developed to monitor thermal lesion formation. Two related methods have been developed for this purpose 33,34 which, although appear to be promising in theory and in phantom testing, have yet to be applied successfully in-vivo. One problem encountered was that the statistics of the speckle pattern observed in phantoms and assumed in the theoretical models (Raleigh) was different when compared to speckle statistics observed in real tissues (k-distributed).…”

Section: Image Monitoringmentioning

confidence: 98%

Interstitial microwave thermal therapy and its application to the treatment of recurrent prostate cancer

Sherar

Trachtenberg

Davidson

et al. 2004

International Journal of Hyperthermia

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Interstitial microwave thermal therapy may be an effective alternative to surgery for the treatment of some solid tumours. Arrays of helical antennae can produce complex heating patterns which when combined with active cooling of normal tissue structures can provide conformal heating for thermal coagulation of tumours. The development of a clinical protocol involving phantom and animal model studies, treatment planning, tissue property measurement and methods for on-line treatment monitoring is reviewed. The technology developed has been applied to the problem of recurrent prostate cancer following failed radiation treatment where available curative options are associated with high normal tissue morbidity. The purpose was to develop a treatment option for this group of patients with a very low side-effect profile that would not preclude further treatment if the disease progressed. Results of a Phase I/II trial demonstrate safety, promising efficacy and a low complication rate. As the technology for delivering this treatment matures, larger multi-institutional trials should be considered.

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“…In addition, the effect on B-Mode images is strongly dependent on the therapeutic device used. Therefore, alternative ultrasound based methods have been widely examined towards their applicability for monitoring of thermal therapies, including temperature estimation [2], attenuation estimation [3], and elastography [4]. The usage of attenuation coefficients is motivated by findings that reveal alterations in the spectral behavior of coagulated tissue.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of ultrasonic texture and spectral parameters for coagulated tissue characterization

Siebers

Schwabe

Scheipers

et al.

IEEE Ultrasonics Symposium, 2004

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Radiofrequency ablation is a well established, minimally invasive approach for the treatment of tumors. However, at present there is a lack of suitable imaging modalities for accurate online monitoring of the coagulation process. The aim of this work is to evaluate the potential of various tissue characterizing ultrasonic parameters from spectral and spatial domain to differentiate between coagulated and noncoagulated tissue. The calculated parameters include first and second order texture parameters, estimates of attenuation coefficients, spectral parameters (slope, intercept and midband value) and coefficients of autoregressive spectral estimates. As a measure of selectivity of each parameter the area under the receiver operating characteristic (ROC) curve was utilized. The best performing parameters can be used to be processed by a classification system.

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B-scan ultrasound imaging of thermal coagulation in bovine liver: frequency shift attenuation mapping

Cited by 48 publications

References 13 publications

An investigation of the use of transmission ultrasound to measure acoustic attenuation changes in thermal therapy

An investigation of the use of transmission ultrasound to measure acoustic attenuation changes in thermal therapy

Interstitial microwave thermal therapy and its application to the treatment of recurrent prostate cancer

Evaluation of ultrasonic texture and spectral parameters for coagulated tissue characterization

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